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Abstract
The conventional method of peripheral nerve gap treatment is autografting. This method is limited. In this study, an aligned nanofibrous graft was formed using microbial polyester, Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The regenerative effect of the graft was compared with that of autografting in vivo. To determine the regenerative effect, rats were assessed with sciatic nerve functional index, electromyographic evaluation, and histological evaluation. Results found in this study include PHBV grafts stimulated progressive nerve regeneration, although regeneration was not comparable with that of autografting. We conclude that the study results were promising for aligned bacterial polymeric grafts for peripheral nerve regeneration.
Acknowledgement
The authors would like to thank Cengiz Uzun and Ahmet Çabuk for characterization of PHBV, Cem Bayram, Özgür Demirbilek and Melike Erol Demirbilek for the preparation of this paper.
Declaration of interest
The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.