Development of gemcitabine-adsorbed magnetic gelatin nanoparticles for targeted drug delivery in lung cancer

Abstract

Magnetic iron oxide nanoparticles (IONPs) were coated with gelatin type B by means of the two-step desolvation method. Drug loading by adsorption was studied under various conditions such as different temperature, contact time, pH, and initial gemcitabine concentration. Further, Langmuir isotherm curves were constracted and constants were calculated. According to the Langmuir isotherm, the Gibbs free energy of the adsorption process at 25°C was − 4.74 kJ/mol. On the other hand, this value at 37°C was − 7.86 kJ/mol. In vitro drug release was performed at pH levels of 5 and 7.4, with gemcitabine-loaded magnetic gelatin nanoparticles and free gemcitabine, and both the results were subsequently compared.

Keywords::

• adsorption
• drug delivery
• gemcitabine
• isotherm
• kinetic modeling
• magnetic gelatin nanoparticles

Acknowledgement

We would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) for financial support received.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.