Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers

Abstract

The aim of the present study is to design a mucoadhesive nano-carrier system which retains at the site of application and maximizes the therapeutic potential of anticancer drug as well as reduces their systemic side effects. In the present study PVA nanofibers of Docetaxel were prepared using electrospinning machine. The resulting nanofibers were characterized through various parameters such as surface morphology, drug loading, in-vitro drug release, tensile strength, mucoadhesiveness, drug permeability, degree of swelling and anticancer activities against selective cell lines to establish their therapeutics potential. On the basis of various evaluation results, we may conclude that the current approach comprising polymeric nanofibers can be successfully used for local delivery of anticancer drug.

Keywords::

• cytotoxicity
• degree of swelling
• electrospinning
• mucoadhesive patch
• nanofibers

Acknowledgement

Authors would like to thank the United Biotech Pvt Ltd, Baddi for providing gift sample of Docetaxel for the research work and ISF College of pharmacy, Moga for providing research facilities.

Declaration of Interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.