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Abstract
Objective: To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone. Methods: From September 2009 to June 2012, 27 cases of bone defect were analyzed retrospectively. The position of bone defect included humerus, radius, ulna, femur, tibia and calcaneus. The range of bone defect was from 0.3 × 1.0 cm to 3 × 6.5 cm. Among them, there were 22 cases with fractures and 5 cases with tumors. All patients were treated with Nano-HA artificial bone. The ability of bone defect repair was evaluated by X-ray exams performed preoperatively and postoperatively. HSS scores were adopted for final evaluation at the latest follow-up. Results: The patients were followed up from 11 to 26 months (average of 18.5 months). No general side effects occurred. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication. Conclusion: The Nano-HA artificial bone had a good biocompatibility and could be an ideal artificial bone in the reconstruction of bone defect.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
This study received financial support from Shenzhen Science and Technology Project (the project number is CXZZ20130321152713220 and GJHZ20130412153906739) and the Guangdong Province Medical Research Fund (the project number is B2012320) and Guangdong Province outstanding youth innovative talent training program (Seedling project, the project number is 2012LYM_0120) and Emerging Scientist Project of Shenzhen Second People's Hospital.