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Abstract
A simulation of tensile strength of various alginate-based hollow microfibers using FEA analysis has been conducted with the hypothesis of macroscopic isotropy and linear elastic-plastic behavior. Results of student t-tests indicated that there was no significant difference between the experimental and simulated tensile strengths (p = 0.37, α = 0.05), while there was a significant reduction in elasticity as a result of chitosan coating (p = 0.024, α = 0.05). The hypothesis of macroscopic isotropy was verified by highly correlated (R2 ≥ 0.92) theoretical and experimental elongation at break measurements, findings that could be extended to the failure analysis of alginate microfibers used in regenerative medicine.
Acknowledgments
Mechanical characterization of the films in the Biomedical Devices Laboratory could not have been executed without access to the custom-designed tensile tester granted by Dr. Guna Selvaduray.
Declaration of interest
The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.