Orally delivered microencapsulated probiotic formulation favorably impacts polyp formation in APC (Min/+) model of intestinal carcinogenesis

Aleksandra Malgorzata UrbanskaBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology Artificial cells and Organs Research Center, Faculty of Medicine, McGill University, University Street, Montreal, QC, Canada

Jasmine BhathenaBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology Artificial cells and Organs Research Center, Faculty of Medicine, McGill University, University Street, Montreal, QC, Canada

Sofiane CherifBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology Artificial cells and Organs Research Center, Faculty of Medicine, McGill University, University Street, Montreal, QC, Canada

Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology Artificial cells and Organs Research Center, Faculty of Medicine, McGill University, University Street, Montreal, QC, Canada

Abstract

The development of intestinal polyps in an orthotopic colorectal mouse model, receiving a probiotic yogurt formulation containing microencapsulated live Lactobacillus acidophilus cells was investigated. The expression of various immunohistochemical markers namely CD8, Mac-1, Ki-67, and cleaved caspase-3, was evaluated. Results suggest that the probiotic formulation decreases overall intestinal inflammation. Mice receiving the probiotic formulation were found to develop almost two-fold fewer tumors in the small intestines. In the large intestine, however, there was no significant difference observed among polyp numbers. The formulation appears to have potential application in the prevention of various GI pathological conditions.

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Acknowledgments

The authors also acknowledge and thank Ms. Melina Narlis for histological sample preparation.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

The authors would like to acknowledge support by a Post Graduate Scholarship from NSERC (to AMU), a Doctoral Research Award from CIHR (to JB), and research grant from CIHR and Micropharma for financial support (to SP).

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Orally delivered microencapsulated probiotic formulation favorably impacts polyp formation in APC (Min/+) model of intestinal carcinogenesis

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Orally delivered microencapsulated probiotic formulation favorably impacts polyp formation in APC (Min/+) model of intestinal carcinogenesis

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