Nanostructured lipid carriers as a potential vehicle for Carvedilol delivery: Application of factorial design approach

Abstract

Present invention relates to design of nanostructured lipid carriers (NLC) to augment oral bioavailability of Carvedilol (CAR). In this attempt, formulations of CAR-NLCs were prepared with glyceryl-monostearate (GMS) as a lipid, poloxamer 188 as a surfactant and tween 80 as a co-surfactant using high pressure homogenizer by 2³ factorial design approach. Formed CAR-NLCs were assessed for various performance parameters. Accelerated stability studies demonstrated negligible change in particle size and entrapment efficiency, after storage at specified time up to 3 months. The promising findings in this investigation suggest the practicability of these systems for enhancement of bioavailability of drugs like CAR.

Keywords::

• design expert
• high pressure homogenization
• nanostructured lipid carrier

Acknowledgments

Authors gratefully acknowledge STIC, Cochin University, Cochin for spectral support. The authors are also grateful to the Management of H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur for providing the necessary facilities, support and encouragement.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.