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Abstract
Context
The size of nanoparticles plays a pivotal role in determining the gene delivery efficiency.
Objective
A focus on the studies done to investigate the effect of nanoparticles size on biological aspects of gene delivery.
Methods
A through literature survey has been done regarding studies done to investigate the effect of nanoparticles size on uptake, transfection efficiency and biodistribution has been cited in the present review.
Results and conclusion
The gene delivery efficacy may depend on conjugation of several factors such as the chemical structure of polymers, cell type, and nanoparticle size, composition and interaction with cells.
Acknowledgments
The authors gratefully acknowledge the help rendered by Rajesh Ranjan (IRIC, University of Montreal, Montreal) for helping with literature access.
Declaration of interest
The authors report no declaration of interest. The authors alone are responsible for the content and writing of the paper.
This work was supported by Science & Engineering Research Board (SERB), Department of Science and Technology (SERC Fast Track Proposals for Young Scientists Scheme), and Government of India.