Permeability study of ciprofloxacin from ultra-thin nanofibrous film through various mucosal membranes

Abstract

Permeability plays an important role to achieve the desired therapeutic outcomes. Present study was designed to investigate the permeability of ciprofloxacin from ultrathin polyvinyl alcohol nanofiber through different biological membranes. Results of the permeability studies indicated that nanofibers exhibit higher drug permeability than plane drug. Intestinal tissue shows maximum permeability followed by eye, trachea, sublingual, rectal, and skin. Permeability studies also inferred a steady-state release of drug of the nanofiber, whereas a high degree of fluctuations was observed in plane drug. Nanofiber being 2D nanoscale material provides numerous advantages to be used as an encapsulated carrier system to improve the therapeutic effectiveness.

Keywords::

• ciprofloxacin
• drug permeability
• nanofibers
• polyvinyl alcohol

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.