Synthesis, characterization, biocompatibility of hydroxyapatite–natural polymers nanocomposites for dentistry applications

Abstract

Hydroxyapatite (HA), the main mineral component of bones and teeth, was synthesized by using the reaction between calcium nitrate tetrahydrate Ca(NO₃)₂∙4H₂O and diammonium hydrogen phosphate (NH₄)₂HPO₄ (DAHP) with a chemical precipitation method. The objective of this study is to utilize novel inorganic–organic nanocomposites for biomedical applications. HA is an inorganic component (75% w) and chitosan, alginate and albumin (Egg white) are organic components of nanocomposites (25% w). Nanocomposites were prepared in deionized water solutions, at room temperature, using a mechanical and magnetic stirrer for 48 h. The microstructure and morphology of sintered n-HAP were tested at different preheating temperature and laser sintering speed with scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR).

Keywords::

• biomedical applications
• hydroxyapatite
• inorganic–organic nanocomposite
• natural polymers

Authors’ contributions

JHC conceived the study and participated in its design and coordination. YKK participated in the sequence alignment and drafted the manuscript. AA, MA, SD, MM, GA, MS, KHK, and TYK helped in drafting the manuscript. All authors read and approved the final manuscript.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2008-0062282).