Capsaicin-loaded vesicular systems designed for enhancing localized delivery for psoriasis therapy

Abstract

The aim of the current investigation is to evaluate the potential of capsaicin (CAP)-containing liposomes, niosomes and emulsomes in providing localized and controlled delivery, to improve the topical delivery of drug. CAP-bearing systems were prepared by the film hydration method and compared through various in vitro and in vivo parameters. The TEM photographs suggested that the carrier systems were spherical in shape and nanometric in size range. Skin retention studies of CAP from in vitro and in vivo experiments revealed significantly higher accumulation of drug in the case of the emul-gel formulation. Based on the results, we concluded that the emul-gel may be a potential approach for the topical delivery of CAP, for an effective therapy for psoriasis.

Keywords::

• capsaicin
• localized effect
• psoriasis
• topical delivery
• vesicular system

Acknowledgements

The authors acknowledge the help of Professor S. C. Lakhotia and Professor J. C. Roy (Department of Zoology, Banaras Hindu University (BHU), Varanasi, India) in the confocal microscopy study. One of the authors, Ruchi Gupta, wants to acknowledge the help of Mr. Praveen Garg, Chairman, ISF College of Pharmacy, Moga, Punjab, for providing excellent research facilities.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.