Useful agents against aflatoxin B₁ – antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine

Abstract

The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin Bı (AFBı) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFBı-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFBı.

Keywords::

• antimicrobial properties
• aflatoxin Bı
• Mn(III) complexes
• mutagenicity

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This research was supported by the Gazi University Research Fund (Project number: 05/2010-03).