Formulation, characterization, and evaluation of ligand-conjugated biodegradable quercetin nanoparticles for active targeting

Abstract

The aim of this study was to design a targeted drug delivery system carrying a natural anticancer drug Quercetin (Qu), specifically for skin cancer. A central composite design was applied separately for each ligand, and the quadratic model was used for the process. The surface morphology was confirmed by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR), and in vitro release studies were also performed. The MTT assay was performed against two different cell lines, to measure their anticancer potentials and their targeting ability. The study thus reveals that MA-Qu-PLGA and FA-Qu-PLGA nanoparticles (NPs) can be used as effective drug delivery systems for skin cancer treatment encompassing natural drugs.

Keywords::

• folate
• mannose
• MTT assay
• nanoparticles
• response surface methodology
• targeted drug delivery

Acknowledgements

The authors acknowledge the University Grant Commission-SAP [F. No.3-54/2011(SAP-II)], New Delhi, India, and the University Grant Commission (UGC), New Delhi, Under MRP Scheme Major Research project, F. No 39-170/2010 (SR), for financial assistance. One of the authors extend their gratitude towards the head of the Cosmetic Lab, University Institute of Pharmacy, Pt., Ravishankar Shukla University, Raipur (C.G.), for providing facilities to carry out research work.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.