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Abstract
Glutaraldehyde-polymerized porcine hemoglobin (pPolyHb) is a hemoglobin-based oxygen carrier currently being developed as a potential red blood cell substitute. We assessed the protective effect of pPolyHb on transient focal cerebral ischemia/reperfusion (I/R) injury. Several outcomes were tested, including infarct size, neurological score, production of inflammatory factors, and markers of oxidative status. Our results show that pPolyHb can not only significantly reduce infarct volume and improve neurological score, but can also inhibit the expression of TNF-α and IL-1β. Furthermore, the generation of MDA and MPO was reduced by pPolyHb. We conclude that pPolyHb has a positive effect on transient focal cerebral I/R injury.
Acknowledgements
We acknowledge with thanks the grants from the National High-tech R&D Program (863 Program) (grant nos. 2012AA021902), National Natural Science Foundation of China (grant nos. 81102367), China Scholarship Council of the Ministry of Education, as well as grants from the Shaanxi Science and Technology Department (grant nos.2011KTCL03-23 and 2011 K12-03-10).
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.