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Abstract
Polymerized porcine hemoglobin (pPolyHb), which was synthesized from chemically modified porcine hemoglobin, can carry and deliver oxygen to tissues in addition to restoring intravascular volume. Assessment of the inflammatory response generated in the host is a part of the overall safety evaluation of pPolyHb. In this study, we measured the levels of IL-1β, IL-10, and CD11b/CD18 in response to pPolyHb stimulation, both in vivo (in rats) and in vitro. Our results suggest that the levels of these indicators are not statistically changed by pPolyHb, indicating that pPolyHb is not immunotoxic to cells and animals in this respect.
Acknowledgement
We acknowledge with thanks the grants from National High-tech R & D Program (863 Program) (grant nos. 2012AA021902), National Natural Science Foundation of China (grant nos. 81102367), China Scholarship Council of the Ministry of Education, as well as grants from Shaanxi Science and Technology Department (grant nos. 2011KTCL03-23, 2011 K12-03-10).
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.