Agammaglobulinemia with Arthritis and Celiac Disease Developing after Infectious Mononucleosis: Follow-up Study of a Case

Abstract

A previously healthy 2½-year-old boy from a healthy family developed agammaglobulinemia with arthritis 3 months after infectious mononucleosis (IM). The response of serum immunoglobulins at the initial stage of IM was typical, with greatly elevated IgM and a positive IM-specific heterophil antibody test. A secondary celiac disease was diagnosed one year after IM. Considering the serum immunoglobulin levels and the normal half-lives of IgM and IgG, it seems very probable that the synthesis of immunoglobulins ceased about one month after the onset of IM. The role of suppressor T-cells in the development of acquired secondary agammaglobulinemia is discussed.