Interferon Treatment in Acute Hepatitis b Infection with Prolonged Course

Sten Iwarson Department of Infectious Diseases, University of Göteborg, Göteborg, the Department of Virology, University of Lund, Lund, and the Medical Research Department, KABI AB, Stockholm, Sweden

Gunnar Norkrans Department of Infectious Diseases, University of Göteborg, Göteborg, the Department of Virology, University of Lund, Lund, and the Medical Research Department, KABI AB, Stockholm, Sweden

Erik Nordenfelt Department of Infectious Diseases, University of Göteborg, Göteborg, the Department of Virology, University of Lund, Lund, and the Medical Research Department, KABI AB, Stockholm, Sweden

Roland Hagberg Department of Infectious Diseases, University of Göteborg, Göteborg, the Department of Virology, University of Lund, Lund, and the Medical Research Department, KABI AB, Stockholm, Sweden

Abstract

Interferon treatment (3.0 × 10⁶ units of human leucocyte interferon) was initiated in a 64-year-old woman with acute hepatitis B infection showing a prolonged course. A decline in serum bilirubin, HBsAg and DNA polymerase activity started during the 10-day period of interferon treatment, and 4 weeks after start of treatment the liver function tests were quite normal. It is possible that the interferon treatment had a beneficial influence on the clinical course of the illness and may be worth trying also in acute fulminant cases of viral hepatitis.

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Interferon Treatment in Acute Hepatitis b Infection with Prolonged Course

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Interferon Treatment in Acute Hepatitis b Infection with Prolonged Course

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