A case of mixed connective tissue disease presenting with nephrotic syndrome

Hiro KurodaDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, JapanCorrespondence[email protected]

Keita IshiiDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan

Yuji NegoroDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan

Hiroko SugiyamaDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan

Junko InoueDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan

Chiga OgurusuDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan

Takeshi KikuchiDepartment of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan

Keisei ShimoeDepartment of Dermatology, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuyama, Japan

Katsutoshi SunamiDepartment of Orthopedic Surgery, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuyama, Japan

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Abstract

A 70-year-old woman was admitted to our hospital for the treatment of diffuse scleroderma and marked edema in the lower extremities. Renal biopsy revealed membranous change, interstitial nephritis, and intimal hyperplasia of the small arteries. The patient was diagnosed as having mixed connective tissue disease (MCTD) presenting with nephrotic syndrome (NS). She responded well to a combination treatment consisting of methylprednisolone (m-PSL) pulse therapy, oral PSL, and cyclosporine A (CsA). We speculated on the actual pathogenesis of NS in this case of MCTD.

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A case of mixed connective tissue disease presenting with nephrotic syndrome

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A case of mixed connective tissue disease presenting with nephrotic syndrome

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