Panniculitis in a patient with mixed connective tissue disease

Masahiro NakashimaDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanCorrespondence[email protected]

Kimihiro SuzukiDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

Makoto OkadaDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

Koji KataharadaDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

Kunio TakadaDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

Takashi NakanishiDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

Masami KobayashiDepartment of Dermatology, National Defense Medical Collage, Tokorozawa, Japan

Fumitaka OhsuzuDepartment of Internal Medicine I, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

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Abstract

A 51-year-old woman who had been suffering from mixed connective tissue disease (MCTD) for 8 years developed an erythematous rash with pain and tenderness on her left leg. A skin biopsy revealed septal panniculitis with multiple lymphangiectasis. No vasculitis was observed. An increase in her prednisolone dose from 5 mg to 20 mg/day led to an improvement in these lesions. Panniculitis is very rare in MCTD. The clinical significance of panniculitis in MCTD is also discussed.

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