A case of relapsing polychondritis with bilateral sensorineural hearing loss and perforation of the nasal septum at the onset

Tokutaro TsudaInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Ayako NakajimaInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Sayumi BabaInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Kiyoko TanoharaInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Ikuko MasudaInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Toru YamadaInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Kae TakagiInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Takuya YamakawaYamakawa Otorhinolaryngological Clinic,Tokyo, Japan

Naoyuki KamataniInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, Japan

Masako HaraInstitute of Rheumatology, Aoyama Hospital, Tokyo Women's Medical University,2-7-13 Kita-Aoyama, Minato-ku, Tokyo 107-0061, JapanCorrespondence[email protected]

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Abstract

A 33-year-old woman suffered from epistaxis and perforation of the nasal septum. Based on a biopsy of nasal mucosa, Wegener's granulomatosis was suspected initially. Her nasal symptoms improved spontaneously, but tinnitus, hearing loss, and dizziness appeared within 3 months. Laboratory analyses revealed no inflammation, and antineutrophil cytoplasmic antibodies were negative. Audiometry revealed bilateral sensorineural hearing loss. A second biopsy of the nasal septum showed an inflammatory change in the cartilage. Thus we diagnosed early-stage relapsing polychondritis.

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A case of relapsing polychondritis with bilateral sensorineural hearing loss and perforation of the nasal septum at the onset

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A case of relapsing polychondritis with bilateral sensorineural hearing loss and perforation of the nasal septum at the onset

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