Therapeutic efficacy and safety profile of infliximab in active systemic lupus erythematosus

Abstract

Since levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) are significantly increased in systemic lupus erythematosus (SLE) and may be involved in the disease pathogenesis, we report on the safety and efficacy of infliximab, a chimeric monoclonal antibody directed against TNFα, given to a patient with difficult-to-treat active nonrenal SLE. This patient, who failed to remit with full doses of glucocorticoids, hydroxychloroquine, methotrexate, and azathioprine, went into sustained remission with the addition of infliximab infusions. Glucocorticoids could be tapered off completely.

Key words::

• Infliximab
• Systemic lupus erythematosus
• Tumor necrosis factor alpha
• Tumor necrosis factor alpha blocker