Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis

Kayoko KanekoDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Toshihiro NankiDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;Department of Pharmacovigilance, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, JapanCorrespondence[email protected]

Tadashi HosoyaDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Fumitaka MizoguchiDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Nobuyuki MiyasakaDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Abstract

We present two patients with rheumatoid arthritis (RA) who developed necrotizing crescentic glomerulonephritis (NCGN) during etanercept therapy. Both patients developed proteinuria and hematuria, and one progressed to renal failure. Renal biopsy revealed NCGN. In both patients, nephritis improved following discontinuation of etanercept and administration of prednisolone. Physicians should be aware of etanercept-induced GN in patients with RA on anti-tumor necrosis factor therapy.

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Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis

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Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis

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