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Case Report

Elevation of serum KL-6 levels in 3 patients with rheumatoid arthritis treated with adalimumab

, , , , &
Pages 147-151 | Received 23 Feb 2011, Accepted 27 May 2011, Published online: 02 Jan 2014
 

Abstract

We describe 3 cases of rheumatoid arthritis presenting with elevated serum KL-6 levels during treatment with adalimumab, which was discontinued because of suspected onset of complications. However, no complications were observed following discontinuation despite comprehensive assessments, and KL-6 levels subsequently returned to baseline levels. In our institutes, 3 out of 29 cases treated with adalimumab showed elevated KL-6 levels. The baseline levels were 445, 347, and 547 U/ml, while the peak levels were 1010, 546, and 2007 U/ml, respectively. The elevated KL-6 levels seem to have been innocuous; nevertheless, further careful observation is deemed necessary.

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