CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

Giulia PazzolaRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Luigi BoiardiRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Bruno CasaliMolecular Biology Laboratory, Department of Oncology, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Enrico FarnettiMolecular Biology Laboratory, Department of Oncology, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Davide NicoliMolecular Biology Laboratory, Department of Oncology, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Nicolò PipitoneRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Ilaria PadovanoRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Andrea CarusoRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Mariagrazia CatanosoRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy

Carlo SalvaraniRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale S Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento n 80, 42100 Reggio Emilia, Italy;Servizio di Reumatologia, Azienda Ospedaliera ASMN-IRCCS, Viale Risorgimento 80, 42123 Reggio Emilia, ItalyCorrespondence[email protected]

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Abstracts

Objectives To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients.

Methods 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism.

Results No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups.

Conclusions Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.

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CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

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CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

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