Health-related quality-of-life in patients after elective surgery for abdominal aortic aneurysm

Abstract

Purpose:

The purpose of this study was to describe the health-related quality-of-life (QoL) in patients after elective surgery for abdominal aortic aneurysm (AAA) compared to a normal population and to study the association between QoL and number of years since surgery.

Methods:

All Danish men who underwent elective surgery for AAA at the age of 65 or more in the period from 1989–2007 in Denmark were invited to participate in the survey. Of 722 patients, 375 were alive and 328 (87%) responded. The instruments EQ-5D (European Quality of life), EQ-VAS and SF-12 (Short Form Health Survey) were applied for measuring health-related QoL. Multiple regression analysis was used to study the association between QoL and number of years since AAA surgery.

Results:

A significantly poorer QoL was found in patients having had AAA surgery compared to the normal population as measured with the SF-12 and the EQ-VAS, but not with EQ-5D. A negative association between QoL and years following surgery was found with EQ-VAS and SF-12 (PCS), but not with the other instruments.

Discussion:

Factors such as selection bias because of mortality and non-response may have resulted in an over-estimate of the QoL in patients having had AAA surgery, thus the difference in QoL compared to the normal population was probably under-estimated. The cross-section design was inefficient for the study of the association between QoL and years since surgery, and EQ-5D may be an insensitive instrument for measuring QoL in AAA patients after surgery.

Limitations:

The main limitation of the study was the cross-sectional design. Males with a higher risk of death were under-represented in the sample.

Conclusion:

A poorer quality-of-life was found in patients having had elective AAA surgery compared to the normal population.

Keywords::

• Cost effectiveness
• Quality-of-life
• Abdominal aortic aneurysm
• EQ-5D

Transparency

Declaration of funding:

Funding was received from the Center for Public Health, Health Technology Assessment and Health Services Research, Aarhus Denmark

Declaration of financial/other relationships:

The authors have no financial/other interests to declare.

Acknowledgments:

No assistance in the preparation of this article is to be declared.