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Pharmaceutical Biology Volume 40, 2002 - Issue 6
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Research Article

Anticonvulsant and GABA Uptake Inhibition Properties of Venom Fractions from the Spiders Parawixia bistriata and Scaptocosa raptoria

M.A.R. Cairrão Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;
,
A.M. Ribeiro Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;
,
A.B. Pizzo Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;
,
A.C.K. Fontana Laboratorio de Neuroquimica, Departamento de Bioquimica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo.
,
R.O. Beleboni Laboratorio de Neuroquimica, Departamento de Bioquimica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo.
,
J. Coutinho-Netto Laboratorio de Neuroquimica, Departamento de Bioquimica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo.
,
A. Miranda Departamento de Biofisica, Universidade Federal de Sao Paulo
&
W.F. Santos Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;
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Pages 472-477 | Published online: 29 Sep 2008

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Kinga Sałat & Katarzyna Kulig. (2011) GABA Transporters as Targets for New Drugs. Future Medicinal Chemistry 3:2, pages 211-222.
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Articles from other publishers (24)

Syafiq Asnawi Zainal Abidin, Anthony Kin Yip Liew, Iekhsan Othman & Farooq Shaikh. (2024) Animal Venoms as Potential Source of Anticonvulsants. F1000Research 13, pages 225.
Crossref
Lívea Godoy, José Liberato, Marcus Celani, Leonardo Gobbo-Neto, Norberto Lopes & Wagner dos Santos. (2017) Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model. Toxins 9:9, pages 262.
Crossref
José Luiz Liberato & Wagner Ferreira dos Santos. 2016. Spider Venoms. Spider Venoms 155 174 .
Victoria Monge-Fuentes, Flávia Maria Medeiros Gomes, Gabriel Avohay Alves Campos, Juliana de Castro Silva, Andréia Mayer Biolchi, Lilian Carneiro dos Anjos, Jacqueline Coimbra Gonçalves, Kamila Soares Lopes & Márcia Renata Mortari. (2015) Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders. Journal of Venomous Animals and Toxins including Tropical Diseases 21:1.
Crossref
D A M F Nôga, F C Cagni, J R Santos, D Silva, D L O Azevedo, A Araújo, R H Silva & A M Ribeiro. (2015) Pro- and Anticonvulsant Effects of the Ant Dinoponera quadriceps (Kempf) Venom in Mice. Neotropical Entomology 44:4, pages 410-417.
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WagnerFerreira dos Santos, HeleneAparecida Fachim, MarciaRenata Mortari & Leonardo Gobbo-Netto. (2015) Neuroprotective activity of parawixin 10, a compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae) in rats undergoing intrahippocampal NMDA microinjection. Pharmacognosy Magazine 11:43, pages 579.
Crossref
José Luiz Liberato & Wagner Ferreira dos Santos. 2015. Spider Venoms. Spider Venoms 1 16 .
Gizeli S. Gimenez, Antonio Coutinho-Neto, Anderson M. Kayano, Rodrigo Simões-Silva, Frances Trindade, Alexandre de Almeida e Silva, Silvana Marcussi, Saulo L. da Silva, Carla F. C. Fernandes, Juliana P. Zuliani, Leonardo A. Calderon, Andreimar M. Soares & Rodrigo G. Stábeli. (2014) Biochemical and Functional Characterization of Parawixia bistriata Spider Venom with Potential Proteolytic and Larvicidal Activities . BioMed Research International 2014, pages 1-13.
Crossref
Helene Aparecida Fachim, Alexandra Olimpio Siqueira Cunha, Adriana Colsera Pereira, René Oliveira Beleboni, Leonardo Gobbo-Neto, Norberto Peporine Lopes, Joaquim Coutinho-Netto & Wagner Ferreira dos Santos. (2011) Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). Epilepsy & Behavior 22:2, pages 158-164.
Crossref
Wagner Ferreira dos Santos. 2009. Botulinum Toxin. Botulinum Toxin 471 484 .
R Zhao, X‐Y Zhang, J Yang, C‐C Weng, L‐L Jiang, J‐W Zhang, X‐Q Shu & Y‐H Ji. (2009) Anticonvulsant effect of BmK IT2, a sodium channel‐specific neurotoxin, in rat models of epilepsy. British Journal of Pharmacology 154:5, pages 1116-1124.
Crossref
Márcia Renata Mortari, Alexandra Olimpio Siqueira Cunha, Luzitano Brandão Ferreira & Wagner Ferreira dos Santos. (2007) Neurotoxins from invertebrates as anticonvulsants: From basic research to therapeutic application. Pharmacology & Therapeutics 114:2, pages 171-183.
Crossref
Erica Aparecida Gelfuso, Alexandra Olimpio Siqueira Cunha, Marcia Renata Mortari, Jose Luiz Liberato, Karina Haddad Paraventi, Rene Oliveira Beleboni, Joaquim Coutinho-Netto, Norberto Peporine Lopes & Wagner Ferreira dos Santos. (2007) Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats. Life Sciences 80:6, pages 566-572.
Crossref
José Luiz Liberato, Alexandra Olimpio Siqueira Cunha, Márcia Renata Mortari, Érica Aparecia Gelfuso, René de Oliveira Beleboni, Joaquim Coutinho-Netto & Wagner Ferreira dos Santos. (2006) Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). Brain Research 1124:1, pages 19-27.
Crossref
Renê Oliveira Beleboni, Renato Guizzo, Andréia Cristina Karklin Fontana, Andrea Baldocchi Pizzo, Ruither Oliveira Gomes Carolino, Leonardo Gobbo-Neto, Norberto Peporine Lopes, Joaquim Coutinho-Netto & Wagner Ferreira dos Santos. (2006) Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine . Molecular Pharmacology 69:6, pages 1998-2006.
Crossref
Marcelo Cairrão Araujo Rodrigues, Luis Henrique Souza Guimarães, José Luis Liberato, Maria de Lourdes Teixeira de Moraes Polizeli & Wagner Ferreira dos Santos. (2006) Acid and alkaline phosphatase activities of a fraction isolated from Parawixia bistriata spider venom. Toxicon 47:8, pages 854-858.
Crossref
Wagner Ferreira dos Santos & Joaquim Coutinho‐Netto. (2006) Effects of the paratemnus elongatus pseudoscorpion venom in the uptake and binding of the L ‐glutamate and GABA from rat cerebral cortex . Journal of Biochemical and Molecular Toxicology 20:1, pages 27-34.
Crossref
Márcia Renata Mortari, Alexandra Olimpio Siqueira Cunha, Luciana De Oliveira, Eveline Bis Vieira, Erica Aparecida Gelfuso, Joaquim Coutinho‐Netto & Wagner Ferreira dos Santos. (2005) Anticonvulsant and Behavioural Effects of the Denatured Venom of the Social Wasp Polybia occidentalis (Polistinae, Vespidae) . Basic & Clinical Pharmacology & Toxicology 97:5, pages 289-295.
Crossref
Alexandra Olimpio Siqueira Cunha, Márcia Renata Mortari, Luciana Oliveira, Ruither Oliveira Gomes Carolino, Joaquim Coutinho-Netto & Wagner Ferreira dos Santos. (2005) Anticonvulsant effects of the wasp Polybia ignobilis venom on chemically induced seizures and action on GABA and glutamate receptors. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 141:1, pages 50-57.
Crossref
Alessandra Mussi-Ribeiro, Antonio Miranda, Leonardo Gobbo-Netto, Norberto Peporine Lopes & Wagner Ferreira dos Santos. (2004) A anticonvulsive fraction from Scaptocosa raptoria (Araneae: Lycosidae) spider venom. Neuroscience Letters 371:2-3, pages 171-175.
Crossref
Renê de O. Beleboni, Andrea B. Pizzo, Andréia C.K. Fontana, Ruither de O.G. Carolino, Joaquim Coutinho-Netto & Wagner F. dos Santos. (2004) Spider and wasp neurotoxins: pharmacological and biochemical aspects. European Journal of Pharmacology 493:1-3, pages 1-17.
Crossref
Marcelo Cairrão Araujo Rodrigues, Renato Guizzo, Leonardo Gobbo-Neto, Richard John Ward, Norberto Peporine Lopes & Wagner Ferreira dos Santos. (2004) The biological activity in mammals and insects of the nucleosidic fraction from the spider Parawixia bistriata. Toxicon 43:4, pages 375-383.
Crossref
Marcelo Cairrão Araujo Rodrigues, Renê de Oliveira Beleboni, Joaquim Coutinho-Netto, Wagner Ferreira dos Santos & Norberto Garcia-Cairasco. (2004) Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol. Epilepsy Research 58:2-3, pages 155-165.
Crossref
Andréia Cristina Karklin Fontana, Renato Guizzo, Renê de Oliveira Beleboni, Antonio Renato Meirelles e Silva, Norberto Cysne Coimbra, Susan G Amara, Wagner Ferreira dos Santos & Joaquim Coutinho‐Netto. (2009) Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake . British Journal of Pharmacology 139:7, pages 1297-1309.
Crossref

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