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Research Article

Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty

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Pages 250-254 | Published online: 08 Jul 2009

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Read on this site (5)

Jamie S McConnell, Sandeep Shewale, Niall A Munro, Kalpesh Shah, Angela H Deakin & Andrew WG Kinninmonth. (2011) Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. Acta Orthopaedica 82:6, pages 660-663.
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Torsten Johansson, Larsgöran Pettersson & Björn Lisander. (2005) Tranexamic acid in total hip arthroplasty saves blood and money. Acta Orthopaedica 76:3, pages 314-319.
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Henrik Husted, Lars Blønd, Stig Sonne-Holm, Gitte Holm, Tine Jacobsen & Peter Gebuhr. (2003) Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplastyA prospective randomized double-blind study in 40 patients . Acta Orthopaedica Scandinavica 74:6, pages 665-669.
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Göran Benoni, Hans Fredin, Richard Knebel & Paul Nilsson. (2001) Blood conservation with tranexamic acid in total hip arthroplasty: A randomized, double-blind study in 40 primary operations. Acta Orthopaedica Scandinavica 72:5, pages 442-448.
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Articles from other publishers (94)

Victoria N Gibbs, Rita Champaneria, Josie Sandercock, Nicky J Welton, Louise J Geneen, Susan J Brunskill, Carolyn Dorée, Catherine Kimber, Antony JR Palmer & Lise J Estcourt. (2024) Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2024:1.
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Che Zheng, Jun Ma, Jiawen Xu, Liming Wu, Yuangang Wu, Yuan Liu & Bin Shen. (2023) The optimal regimen, efficacy and safety of tranexamic acid and aminocaproic acid to reduce bleeding for patients after total hip arthroplasty: A systematic review and Bayesian network meta-analysis. Thrombosis Research 221, pages 120-129.
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M. Balik, J. Kosina, P. Husek, J. Pacovsky, M. Brodak & F. Cecka. (2022) Can the prophylactic administration of tranexamic acid reduce the blood loss after robotic-assisted radical prostatectomy? Robotic Assisted Radical Prostatectomy with tranEXamic acid (RARPEX): study protocol for a randomized controlled trial. Trials 23:1.
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Hemail M. Alsubaie, Ahmed Abu-Zaid, Suhail I. Sayed, K. Alok Pathak, Mohammed A. Almayouf, Majed Albarrak, Saleh F. Aldhahri & Khalid H. Al-Qahtani. (2021) Tranexamic acid in head and neck procedures: a systematic review and meta-analysis of randomized controlled trials. European Archives of Oto-Rhino-Laryngology 279:5, pages 2231-2238.
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JOSÉ ALBERTO ALVES OLIVEIRA, GABRIELLA CRISTINA COELHO DE BRITO, FRANCISCA MAGNA PRADO BEZERRA, CARLOS ALFREDO DE CARVALHO NETO, JONATAS BRITO DE ALENCAR NETO & ROBERTO CÉSAR PONTES IBIAPINA. (2021) THE USE OF ANTIFIBRINOLYTICS IN HIP TRAUMA SURGERY IN A PUBLIC HEALTH SYSTEM: A PROSPECTIVE STUDY. Acta Ortopédica Brasileira 29:6, pages 304-307.
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Seyed Muhammad Mehdi Ghaffari Hamedani, Ali Akbari, Sohrab Sayaydi, Zakaria Zakariaei, Mahmood Moosazadeh, Javad Boskabadi, Mahshid Naserifar & Saeed Kargar Soliemanabad. (2021) The topical application of tranexamic acid to control bleeding in inguinal hernia surgery candidate patients: A randomized controlled trial. Annals of Medicine and Surgery 69, pages 102683.
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Isabel Taeuber, Stephanie Weibel, Eva Herrmann, Vanessa Neef, Tobias Schlesinger, Peter Kranke, Leila Messroghli, Kai Zacharowski, Suma Choorapoikayil & Patrick Meybohm. (2021) Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality. JAMA Surgery 156:6, pages e210884.
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Davide Reale, Luca Andriolo, Safa Gursoy, Murat Bozkurt, Giuseppe Filardo & Stefano Zaffagnini. (2021) Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International 2021, pages 1-14.
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Mohamed Sukeik, Sattar Alshryda, James Powell & Fares S. Haddad. (2020) The effect of tranexamic acid on wound complications in primary total Hip Arthroplasty: A meta-analysis. The Surgeon 18:1, pages 53-61.
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Michal Balík, Josef Košina, Petr Hušek, Miloš Broďák & Filip Čečka. (2020) Safety and Efficacy of Using Tranexamic Acid at the Beginning of Robotic-Assisted Radical Prostatectomy in a Double-Blind Prospective Randomized Pilot Study. Acta Medica (Hradec Kralove, Czech Republic) 63:4, pages 176-182.
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Javahir A. Pachore, Vikram Indrajit Shah, Sachin Upadhyay, Kalpesh Shah, Ashish Sheth & Amish Kshatriya. (2019) The use of tranexamic acid to reduce blood loss in uncemented total hip arthroplasty for avascular necrosis of femoral head: a prospective blinded randomized controlled study. Arthroplasty 1:1.
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Zhihu Zhao, Jianxiong Ma & Xinlong Ma. (2019) Comparative efficacy and safety of different hemostatic methods in total hip arthroplasty: a network meta-analysis. Journal of Orthopaedic Surgery and Research 14:1.
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Michal Balík & Jaroslav Pacovský. (2019) Pharmacological prophylaxis of bleeding in urological procedures. Urologie pro praxi 20:1, pages 13-18.
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Jeffrey Yates, Iris Perelman, Simonne Khair, Joshua Taylor, Jacinthe Lampron, Alan Tinmouth & Elianna Saidenberg. (2018) Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta‐analysis. Transfusion 59:2, pages 806-824.
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Byung-Ho Yoon, Tae-young Kim, Young Seung Ko, Young-Kyun Lee, Yong-Chan Ha & Kyung-Hoi Koo. (2018) Optimal use of tranexamic acid for total hip arthroplasty: A network meta-analysis. PLOS ONE 13:10, pages e0206480.
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Kai-di Zhou, Hong-yi Wang, Yi Wang, Zhi-hong Liu, Chuan He & Jian-min Feng. (2018) Is topical or intravenous tranexamic acid preferred in total hip arthroplasty? A randomized, controlled, noninferiority clinical trial. PLOS ONE 13:10, pages e0204551.
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Yale A. Fillingham, Dipak B. Ramkumar, David S. Jevsevar, Adolph J. Yates, Peter Shores, Kyle Mullen, Stefano A. Bini, Henry D. Clarke, Emil Schemitsch, Rebecca L. Johnson, Stavros G. Memtsoudis, Siraj A. Sayeed, Alexander P. Sah & Craig J. Della Valle. (2018) The Efficacy of Tranexamic Acid in Total Hip Arthroplasty: A Network Meta-analysis. The Journal of Arthroplasty 33:10, pages 3083-3089.e4.
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Seher Orbay Yaşlı, Zeynep Tosun, Mehmet Halıcı & Selda Kahraman Kayaaltı. (2018) Effects of high-dose tranexamic acid in total hip replacement: A prospective, double-blind, randomized controlled study. Journal of Surgery and Medicine.
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Dipak B. Ramkumar, Niveditta Ramkumar, Stephanie J. Tapp & Wayne E. Moschetti. (2018) Pharmacologic Hemostatic Agents in Total Joint Arthroplasty—A Cost-Effectiveness Analysis. The Journal of Arthroplasty 33:7, pages 2092-2099.e9.
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Georgi P. Georgiev, Panayot P. Tanchev, Zlatka Zheleva & Plamen Kinov. (2018) Comparison of topical and intravenous administration of tranexamic acid for blood loss control during total joint replacement: Review of literature. Journal of Orthopaedic Translation 13, pages 7-12.
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Pablo Mariani, Martin A. Buttaro, Pablo A. Slullitel, Fernando M. Comba, Gerardo Zanotti, Pablo Ali & Francisco Piccaluga. (2018) Transfusion rate using intravenous tranexamic acid in hip revision surgery. HIP International 28:2, pages 194-199.
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Kannan Sridharan & Gowri Sivaramakrishnan. (2018) Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies. Journal of Orthopaedics 15:1, pages 81-88.
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Nicola Piolanti, Andrea Del Chiaro, Fabrizio Matassi, Angelo Graceffa, Lorenzo Nistri & Massimiliani Marcucci. (2017) Clinical and instrumental evaluation of two different regimens of tranexamic acid in total hip arthroplasty: a single-centre, prospective, randomized study with 80 patients. European Journal of Orthopaedic Surgery & Traumatology 28:2, pages 233-237.
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Jianxi Zhu, Yong Zhu, Pengfei Lei, Min Zeng, Weiping Su & Yihe Hu. (2017) Efficacy and safety of tranexamic acid in total hip replacement. Medicine 96:52, pages e9552.
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Pablo Mariani, Martin A. Buttaro, Pablo A. Slullitel, Fernando M. Comba, Gerardo Zanotti, Pablo Ali & Francisco Piccaluga. (2017) Transfusion rate using intravenous tranexamic acid in hip revision surgery. Hip International, pages 0-0.
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William D. LackBrett D. CristRachel B. Seymour, William HarvinMadhav A. Karunakar. (2017) Effect of Tranexamic Acid on Transfusion: A Randomized Clinical Trial in Acetabular Fracture Surgery. Journal of Orthopaedic Trauma 31:10, pages 526-530.
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Kannan Sridharan & Gowri Sivaramakrishnan. (2017) Tranexamic acid in total hip arthroplasty: A recursive cumulative meta-analysis of randomized controlled trials and assessment of publication bias. Journal of Orthopaedics 14:3, pages 323-328.
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Andrew Fraval, Peter Effeney, Lena Fiddelaers, Belinda Smith, Ben Towell & Phong Tran. (2017) OBTAIN A: Outcome Benefits of Tranexamic Acid in Hip Arthroplasty. A Randomized Double-Blinded Controlled Trial. The Journal of Arthroplasty 32:5, pages 1516-1519.
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Young-Hoo Kim, Jang-Won Park & Jun-Shik Kim. (2017) Chemical Thromboprophylaxis Is Not Necessary to Reduce Risk of Thromboembolism With Tranexamic Acid After Total Hip Arthroplasty. The Journal of Arthroplasty 32:2, pages 641-644.
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Ranjit Kumar Baruah, Pranab Jyoti Borah & Russel Haque. (2016) Use of Tranexamic Acid in Dynamic Hip Screw Plate Fixation for Trochanteric Fractures. Journal of Orthopaedic Surgery 24:3, pages 379-382.
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Joseph T. Moskal & Susan G. Capps. (2016) Meta-analysis of Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty. Orthopedics 39:5.
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Gustavo De Napoli, Juan Ottolenghi & Luis M. Melo. (2016) Comparación de sangrado y transfusiones en artroplastias primarias de cadera y rodilla con monodosis de ácido tranexámico frente a placebo en un hospital universitario. Estudio prospectivo. Revista Colombiana de Ortopedia y Traumatología 30:3, pages 101-106.
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Changde Wang, Pengde Kang, Jun Ma, Chen Yue, Jinwei Xie & Fuxing Pei. (2016) Single-dose tranexamic acid for reducing bleeding and transfusions in total hip arthroplasty: A double-blind, randomized controlled trial of different doses. Thrombosis Research 141, pages 119-123.
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Wayne T. North, Nima Mehran, Jason J. Davis, Craig D. Silverton, Robb M. Weir & Michael W. Laker. (2016) Topical vs Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty: A Double-Blind, Randomized Controlled Trial. The Journal of Arthroplasty 31:4, pages 928-929.
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Zilan X. Lin & Shane K. Woolf. (2016) Safety, Efficacy, and Cost-effectiveness of Tranexamic Acid in Orthopedic Surgery. Orthopedics 39:2, pages 119-130.
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Masaya Ueno, Motoki Sonohata, Norio Fukumori, Shunsuke Kawano, Masaru Kitajima & Masaaki Mawatari. (2016) Comparison between topical and intravenous administration of tranexamic acid in primary total hip arthroplasty. Journal of Orthopaedic Science 21:1, pages 44-47.
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Fei Huang, Yunfeng Wu, Zongsheng Yin, Guangwen Ma & Jun Chang. (2018) A Systematic Review and Meta-Analysis of the Use of Antifibrinolytic Agents in Total Hip Arthroplasty. HIP International 25:6, pages 502-509.
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