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Acta Orthopaedica Scandinavica Volume 71, 2000 - Issue 2
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Research Article

Clodronate increases mineralization of callus after Colles' fracture: A randomized, double-blind, placebo-controlled, prospective trial in 32 patients

Per Adolphson Departments of Orthopaedics, 1Karolinska Institutet at Danderyd Hospital, SE-182 88 Danderyd, Sweden. Tel +46 8-6555000. Fax -7551476. E-mail: [email protected]; 2Uppsala University, Uppsala, Sweden
,
Hassan Abbaszadegan Departments of Orthopaedics, 1Karolinska Institutet at Danderyd Hospital, SE-182 88 Danderyd, Sweden. Tel +46 8-6555000. Fax -7551476. E-mail: [email protected]; 2Uppsala University, Uppsala, Sweden
,
Henrik Bodén Departments of Orthopaedics, 1Karolinska Institutet at Danderyd Hospital, SE-182 88 Danderyd, Sweden. Tel +46 8-6555000. Fax -7551476. E-mail: [email protected]; 2Uppsala University, Uppsala, Sweden
,
Mats Salemyr Departments of Orthopaedics, 1Karolinska Institutet at Danderyd Hospital, SE-182 88 Danderyd, Sweden. Tel +46 8-6555000. Fax -7551476. E-mail: [email protected]; 2Uppsala University, Uppsala, Sweden
&
Tomas Henriques Departments of Orthopaedics, 1Karolinska Institutet at Danderyd Hospital, SE-182 88 Danderyd, Sweden. Tel +46 8-6555000. Fax -7551476. E-mail: [email protected]; 2Uppsala University, Uppsala, Sweden
Pages 195-200 | Published online: 08 Jul 2009

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Stefan H Greiner, Britt Wildemann, David A Back, Mahtala Alidoust, Philipp Schwabe, Norbert P Haas & Gerhard Schmidmaier. (2008) Local application of zoledronic acid incorporated in a poly(D,L-lactide)-coated implant accelerates fracture healing in rats. Acta Orthopaedica 79:5, pages 717-725.
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Per Aspenberg, Karin Wermelin, Pentti Tengwall & Anna Fahlgren. (2008) Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats. Acta Orthopaedica 79:1, pages 111-115.
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Filippo Migliorini, Federico Cocconi, Gianluca Vecchio, Luise Schäefer, Julian Koettnitz & Nicola Maffulli. Pharmacological agents for bone fracture healing: talking points from recent clinical trials.. Expert Opinion on Investigational Drugs 0:0.
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Articles from other publishers (36)

Yongquan Gao, Xiaochen Liu, Yuan Gu, Deye Song, Muliang Ding, Lele Liao, Junjie Wang, Jiangdong Ni & Guangxu He. (2021) The Effect of Bisphosphonates on Fracture Healing Time and Changes in Bone Mass Density: A Meta-Analysis. Frontiers in Endocrinology 12.
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Rebecca Rothe, Sabine Schulze, Christin Neuber, Sandra Hauser, Stefan Rammelt & Jens Pietzsch. (2020) Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation. Clinical Hemorheology and Microcirculation 73:3, pages 439-488.
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Junro Yamashita & Laurie K McCauley. (2019) Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies. JBMR Plus 3:12.
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Andrew D Duckworth, Margaret M McQueen, Christopher E Tuck, Jonathan H Tobias, Jeremy Mark Wilkinson, Leela C Biant, Elizabeth Claire Pulford, Stephen Aldridge, Claire Edwards, Chris P Roberts, Manoj Ramachandran, Andrew Richard McAndrew, Kenneth CK Cheng, Phillip Johnston, Nasir H Shah, Philip Mathew, John Harvie, Birgit C Hanusch, Ronnie Harkess, Aryelly Rodriguez, Gordon D Murray & Stuart H Ralston. (2019) Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo‐Controlled Trial. Journal of Bone and Mineral Research 34:6, pages 1025-1032.
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Monika J. Tomecka, Lalith P. Ethiraj, Luis M. Sánchez, Henry H. Roehl & Tom J. Carney. (2019) Clinical pathologies of bone fracture modelled in zebrafish. Disease Models & Mechanisms.
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Long Chen, Zhou-Shan Tao, Hui Chen, Kailiang Zhou & Dong-Sheng Zhou. (2017) Combined treatment with alendronate and Drynaria rhizome extractsKombinationstherapie mit Alendronat und Drynaria-rhizome-Extrakt. Zeitschrift für Gerontologie und Geriatrie 51:8, pages 875-881.
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Matthew R. Cohn, Arianna L. Gianakos, Kirsten Grueter, Natalie Rosen, Guang-Ting Cong & Joseph M. Lane. (2018) Update on the Comprehensive Approach to Fragility Fractures. Journal of Orthopaedic Trauma 32:9, pages 480-490.
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Sang Yoon Lee, Se Hee Jung, Shi-Uk Lee, Yong-Chan Ha & Jae-Young Lim. (2018) Can Bisphosphonates Prevent Recurrent Fragility Fractures? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of the American Medical Directors Association 19:5, pages 384-390.e1.
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Javier Eduardo Nuñez, Luis Sebastian Ruchelli, Cesar Bartolomeo, Jorge Octavio Flores, Santiago Luis Iglesias & Christian Antonio Allende Nores. (2017) Alendronato administrado en el foco de fractura. Estudio experimental en conejos. [Alendronate administered at the fracture site. Experimental study in rabbits].. Revista de la Asociación Argentina de Ortopedia y Traumatología 82:4, pages 327-333.
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Young Ho Shin & Hyun Sik Gong. (2016) Recent Update in the Diagnosis and Treatment of Bone Frailty in Patients with a Distal Radius Fracture. The Journal of Hand Surgery (Asian-Pacific Volume) 21:03, pages 307-312.
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V. Hegde, J. E. Jo, P. Andreopoulou & J. M. Lane. (2015) Effect of osteoporosis medications on fracture healing. Osteoporosis International 27:3, pages 861-871.
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Deting Xue, Fangcai Li, Gang Chen, Shigui Yan & Zhijun Pan. (2014) Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research 9:1.
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Per Aspenberg. 2014. Distal Radius Fractures. Distal Radius Fractures 101 104 .
S. UchiyamaT. ItsuboK. NakamuraY. FujinagaN. SatoT. ImaedaM. KadoyaH. Kato. (2013) Effect of early administration of alendronate after surgery for distal radial fragility fracture on radiological fracture healing time. The Bone & Joint Journal 95-B:11, pages 1544-1550.
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Per Aspenberg. (2013) Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials. BoneKEy Reports 2:1.
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T-Y. KimY-C. HaB-J. KangY-K. LeeK-H. Koo. (2012) Does early administration of bisphosphonate affect fracture healing in patients with intertrochanteric fractures?. The Journal of Bone and Joint Surgery. British volume 94-B:7, pages 956-960.
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Celeste J. Hamilton, Sophie A. Jamal & Earl R. Bogoch. 2011. Evidence‐Based Orthopedics. Evidence‐Based Orthopedics 35 55 .
S. Bobo Tanner. (2011) Choosing a Treatment for Patients at the Time a Fracture is Presented. Current Osteoporosis Reports 9:3, pages 156-159.
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C. Colón-Emeric, L. Nordsletten, S. Olson, N. Major, S. Boonen, P. Haentjens, P. Mesenbrink, J. Magaziner, J. Adachi, K. W. Lyles, L. Hyldstrup, C. Bucci-Rechtweg & C. Recknor. (2010) Association between timing of zoledronic acid infusion and hip fracture healing. Osteoporosis International 22:8, pages 2329-2336.
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Aaron Nauth, Theodore Miclau, Mohit Bhandari & Emil H Schemitsch. (2011) Use of Osteobiologics in the Management of Osteoporotic Fractures. Journal of Orthopaedic Trauma 25:Supplement 2, pages S51-S55.
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Susan V. Bukata. (2011) Systemic administration of pharmacological agents and bone repair: What can we expect. Injury 42:6, pages 605-608.
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Patricia C. Gregory, Diana Lam & Paul Howell. (2010) Osteoporosis Treatment Following Hip Fracture: How Rates Vary by Service. Southern Medical Journal 103:10, pages 977-981.
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S. Greiner, A. Kadow-Romacker, G. Schmidmaier & B. Wildemann. (2009) Cocultures of osteoblasts and osteoclasts are influenced by local application of zoledronic acid incorporated in a poly(D,L-lactide) implant coating. Journal of Biomedical Materials Research Part A 91A:1, pages 288-295.
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Michelle M. McDonald, Sukhdeep Dulai, Craig Godfrey, Negin Amanat, Tamara Sztynda & David G. Little. (2008) Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone 43:4, pages 653-662.
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Michelle M McDonald, Aaron Schindeler & David G Little. (2007) Bisphosphonate treatment and fracture repair. BoneKEy-Osteovision 4:9, pages 236-251.
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Negin Amanat, Michelle McDonald, Craig Godfrey, Lynne Bilston & David Little. (2007) Optimal Timing of a Single Dose of Zoledronic Acid to Increase Strength in Rat Fracture Repair. Journal of Bone and Mineral Research 22:6, pages 867-876.
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T. Armingeat, R. Brondino, T. Pham, V. Legré & P. Lafforgue. (2006) Intravenous pamidronate for pain relief in recent osteoporotic vertebral compression fracture: a randomized double-blind controlled study. Osteoporosis International 17:11, pages 1659-1665.
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Serena S. Hu & Sigurd H. Berven. (2006) Preparing the Adult Deformity Patient for Spinal Surgery. Spine 31:Suppl, pages S126-S131.
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Cathleen S. Colón-Emeric & Kenneth G. Saag. (2006) Osteoporotic fractures in older adults. Best Practice & Research Clinical Rheumatology 20:4, pages 695-706.
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Michael C. Koester & Kurt P. Spindler. (2006) Pharmacologic Agents in Fracture Healing. Clinics in Sports Medicine 25:1, pages 63-73.
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Negin Amanat, Richard Brown, Lynne E. Bilston & David G. Little. (2006) A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. Journal of Orthopaedic Research 23:5, pages 1029-1034.
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CAROL D. MORRIS & THOMAS A. EINHORN. (2005) BISPHOSPHONATES IN ORTHOPAEDIC SURGERY. The Journal of Bone and Joint Surgery-American Volume 87:7, pages 1609-1618.
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