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Original Article

No augmentation of morselized and impacted bone graft by OP-1 in a weight-bearing model

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Pages 742-748 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Ola Belfrage, Gunnar Flivik, Martin Sundberg, Uldis Kesteris & Magnus Tägil. (2011) Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density. Acta Orthopaedica 82:2, pages 228-233.
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Eleftherios Tsiridis, Zubier Ali, Amit Bhalla, Zakareya Gamie, Manolis Heliotis, Neelam Gurav, Sanjukta Deb & Lucy DiSilvio. (2009) In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1. Expert Opinion on Biological Therapy 9:1, pages 9-19.
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Gerjon Hannink, B. Willem Schreurs & Pieter Buma. (2007) No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks. Acta Orthopaedica 78:4, pages 551-558.
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Nuthan Jagadeesh, Henry Wynn Jones, Bodo Purbach & Nikhil Shah. 2023. Hip Arthroplasty. Hip Arthroplasty 685 696 .
Eun-Sun Jin, Ji Yeon Kim, Bora Lee, JoongKee Min, Sang Ryong Jeon, Kyoung Hyo Choi & Je Hoon Jeong. (2018) Biodegradable Screws Containing Bone Morphogenetic Protein-2 in an Osteoporotic Rat Model. Journal of Korean Neurosurgical Society 61:5, pages 559-567.
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Jorgen Baas, Marianne Vestermark, Thomas Jensen, Joan Bechtold, Kjeld Soballe & Thomas Jakobsen. (2017) Topical bisphosphonate augments fixation of bone-grafted hydroxyapatite coated implants, BMP-2 causes resorption-based decrease in bone. Bone 97, pages 76-82.
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Tae-Hoon Kim, Young-Pil Yun, Young-Eun Park, Suk-Ha Lee, Woonjae Yong, Joydip Kundu, Jin Woo Jung, Jin-Hyung Shim, Dong-Woo Cho, Sung Eun Kim & Hae-Ryong Song. (2014) In vitro and in vivo evaluation of bone formation using solid freeform fabrication-based bone morphogenic protein-2 releasing PCL/PLGA scaffolds . Biomedical Materials 9:2, pages 025008.
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Sun-Young Jung, You-Jin Ko, Hyon-Seok Jang, Sun-Woong Kang & Jung-Ho Park. (2013) The effect of carrier for BMP-2 delivery on histological aspects of tissue-engineered bone. Tissue Engineering and Regenerative Medicine 10:6, pages 341-346.
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Howard J. Seeherman, X. Jian Li, Erica Smith & John M. Wozney. (2012) rhBMP-2/Calcium Phosphate Matrix Induces Bone Formation While Limiting Transient Bone Resorption in a Nonhuman Primate Core Defect Model. Journal of Bone and Joint Surgery 94:19, pages 1765-1776.
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Wan‐Geun La, Sun‐Hyun Kwon, Tae‐Jin Lee, Hee Seok Yang, Jooyeon Park & Byung‐Soo Kim. (2012) The Effect of the Delivery Carrier on the Quality of Bone Formed via Bone Morphogenetic Protein‐2. Artificial Organs 36:7, pages 642-647.
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Kate V. BrownBing LiTeja GudaDaniel S. PerrienScott A. GuelcherJoseph C. Wenke. (2011) Improving Bone Formation in a Rat Femur Segmental Defect by Controlling Bone Morphogenetic Protein-2 Release. Tissue Engineering Part A 17:13-14, pages 1735-1746.
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Howard J. Seeherman, X. Jian Li, Mary L. Bouxsein & John M. Wozney. (2010) rhBMP-2 Induces Transient Bone Resorption Followed by Bone Formation in a Nonhuman Primate Core-Defect Model. The Journal of Bone & Joint Surgery 92:2, pages 411-426.
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Iain R. McNamara. (2010) Impaction bone grafting in revision hip surgery: past, present and future. Cell and Tissue Banking 11:1, pages 57-73.
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Anna Kajsa Harding, Per Aspenberg, Masashi Kataoka, David Bylski & Magnus Tägil. (2008) Manipulating the anabolic and catabolic response in bone graft remodeling: Synergism by a combination of local BMP‐7 and a single systemic dosis of zoledronate. Journal of Orthopaedic Research 26:9, pages 1245-1249.
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J. P. WhittakerR. DharmarajanA. D. Toms. (2008) The management of bone loss in revision total knee replacement. The Journal of Bone and Joint Surgery. British volume 90-B:8, pages 981-987.
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Jorgen Baas, Brian Elmengaard, Thomas B. Jensen, Thomas Jakobsen, Niels T. Andersen & Kjeld Soballe. (2008) The effect of pretreating morselized allograft bone with rhBMP-2 and/or pamidronate on the fixation of porous Ti and HA-coated implants. Biomaterials 29:19, pages 2915-2922.
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T. N. BoardP. RooneyP. R. Kay. (2008) Strain imparted during impaction grafting may contribute to bony incorporation. The Journal of Bone and Joint Surgery. British volume 90-B:6, pages 821-824.
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Pieter Buma, J. J. Chris Arts, Jean W. M. Gardeniers, Nico Verdonschot & B. Willem Schreurs. (2007) No effect of bone morphogenetic protein‐7 (OP‐1) on the incorporation of impacted bone grafts in a realistic acetabular model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 84B:1, pages 231-239.
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Eleftherios Tsiridis, Zubier Ali, Amit Bhalla, Manolis Heliotis, Neelam Gurav, Sanjukta Deb & Lucy DiSilvio. (2007) In vitro and in vivo optimization of impaction allografting by demineralization and addition of rh‐OP‐1. Journal of Orthopaedic Research 25:11, pages 1425-1437.
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Anneliese D. Heiner, John J. Callaghan & Thomas D. Brown. (2007) Stability of fused versus nonfused THA Femoral impaction grafts. Journal of Orthopaedic Research 25:3, pages 351-360.
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T. B. Jensen, S. OvergaardM. LindO. Rahbek, C. BüngerK. Søballe. (2007) Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute. The Journal of Bone and Joint Surgery. British volume 89-B:1, pages 121-126.
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Gerjon Hannink, Per Aspenberg, B Willem Schreurs & Pieter Buma. (2006) High Doses of OP-1 Inhibit Fibrous Tissue Ingrowth in Impaction Grafting. Clinical Orthopaedics and Related Research 452, pages 250-259.
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T. N. BoardP. RooneyJ. N. KearneyP. R. Kay. (2006) Impaction allografting in revision total hip replacement. The Journal of Bone and Joint Surgery. British volume 88-B:7, pages 852-857.
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A. Sachse, A. Wagner, M. Keller, O. Wagner, W.-D. Wetzel, F. Layher, R.-A. Venbrocks, P. Hortschansky, M. Pietraszczyk, B. Wiederanders, H.J. Hempel, J. Bossert, J. Horn, K. Schmuck & J. Mollenhauer. (2005) Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep. Bone 37:5, pages 699-710.
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Jorge Gil-Albarova, Antonio J. Salinas, Antonio L. Bueno-Lozano, Jesus Román, Nicolo Aldini-Nicolo, Agustina García-Barea, Gianluca Giavaresi, Milena Fini, Roberto Giardino & Maria Vallet-Regí. (2005) The in vivo behaviour of a sol–gel glass and a glass-ceramic during critical diaphyseal bone defects healing. Biomaterials 26:21, pages 4374-4382.
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Howard Seeherman & John M. Wozney. (2005) Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine & Growth Factor Reviews 16:3, pages 329-345.
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ANDREW D. TOMS, ROSS L. BARKER, RICHARD SPENCER JONES & JAN HERMAN KUIPER. (2004) IMPACTION BONE-GRAFTING IN REVISION JOINT REPLACEMENT SURGERY. The Journal of Bone and Joint Surgery-American Volume 86:9, pages 2050-2060.
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