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Acta Oto-Laryngologica Volume 122, 2002 - Issue 2
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Research Article

Induction of Mucous Cell Metaplasia in the Middle Ear of Rats Using a Three-step Method: An Improved Model for Otitis Media with Mucoid Effusion

Yasuhiro Tsuboi Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Youngki Kim Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
G. Scott Giebink Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Chap Le Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Michael M. Paparella Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Nengqian Chen Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Patricia A. Schachern Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
,
Steven K. Juhn Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
&
Jizhen Lin Pediatrics, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine
 show all
Pages 153-160 | Published online: 08 Jul 2009

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Read on this site (2)

Yasin K. Varsak & Peter L. Santa Maria. (2016) Mouse model of experimental Eustachian tube occlusion: a surgical technique. Acta Oto-Laryngologica 136:1, pages 12-17.
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Almudena Trinidad, Rafael Ramírez-Camacho, Jose Ramón García-Berrocal, José María Verdaguer, Javier Vicente & María Teresa Pinilla. (2005) Pseudomonas aeruginosa infection in the hypoventilated middle ear: An experimental model. Acta Oto-Laryngologica 125:3, pages 266-269.
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Articles from other publishers (17)

Jae Sang Han, Ye Lin Kim, Hyo Jeong Yu, Jung Mee Park, Yeon Ju Kim, Yun-Hoon Choung, So Young Park & Shi Nae Park. (2022) Safety and efficacy of intratympanic histamine injection as an adjuvant to dexamethasone in a noise-induced murine model. European Journal of Pharmaceutical Sciences 178, pages 106291.
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Jae Sang Han, Ye Lin Kim, Hyo Jeong Yu, Jung Mee Park, Yeonji Kim, So Young Park & Shi Nae Park. (2022) Safety and Efficacy of Intratympanic Alpha-Lipoic Acid Injection in a Mouse Model of Noise-Induced Hearing Loss. Antioxidants 11:8, pages 1423.
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Xiang Liu, Ning Cong, Xiang Cheng, Rui Ma, Jing Wang, Yi-bo Huang, Meng Zhao, Xin-wei Wang, Fang-Lu Chi & Dong-Dong Ren. (2017) The Role of the Notch Signal Pathway in Mucosal Cell Metaplasia in Mouse Acute Otitis Media. Scientific Reports 7:1.
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Stéphanie Val, Katelyn Burgett, Kristy J. Brown & Diego Preciado. (2016) SuperSILAC Quantitative Proteome Profiling of Murine Middle Ear Epithelial Cell Remodeling with NTHi. PLOS ONE 11:2, pages e0148612.
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Stéphanie ValHumaira MubeenAmarel TomneySaisai ChenDiego Preciado. (2023) Impact of Staphylococcus Epidermidis Lysates on Middle Ear Epithelial Proinflammatory and Mucogenic Response. Journal of Investigative Medicine 63:2, pages 258-266.
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Stéphanie Val. 2015. Otitis Media: State of the art concepts and treatment. Otitis Media: State of the art concepts and treatment 53 77 .
Diego PreciadoKatelyn Burgett, Svetlana Ghimbovschi & Mary Rose. (2013) NTHi induction of Cxcl2 and middle ear mucosal metaplasia in mice. The Laryngoscope 123:11.
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Yoshihisa Nakamura, Masahiro Komori, Kazuhiro Yamakawa, Yuki Hamajima, Motohiko Suzuki, Youngki Kim & Jizhen Lin. (2013) Math1, retinoic acid, and TNF-α synergistically promote the differentiation of mucous cells in mouse middle ear epithelial cells in vitro. Pediatric Research 74:3, pages 259-265.
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Jizhen Lin, Per Caye-Thomasen, Tetsuya Tono, Quan-An Zhang, Yoshihisa Nakamura, Ling Feng, Jianmin Huang, Shengnan Ye, Xiaohua Hu & Joseph E. Kerschner. (2012) Mucin Production and Mucous Cell Metaplasia in Otitis Media. International Journal of Otolaryngology 2012, pages 1-12.
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Yoshihisa Nakamura, Yuki Hamajima, Masahiro Komori, Makoto Yokota, Motohiko Suzuki & Jizhen Lin. (2012) The Role of Atoh1 in Mucous Cell Metaplasia. International Journal of Otolaryngology 2012, pages 1-5.
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Yun-Woo Lee, Yunju Chung, Steven K. Juhn, Youngki Kim & Jizhen Lin. (2011) Activation of the Transforming Growth Factor Beta Pathway in Bacterial Otitis Media. Annals of Otology, Rhinology & Laryngology 120:3, pages 204-213.
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Katsuyuki Tsuchiya, Masahiro Komori, Qing Yin Zheng, Patricia Ferrieri & Jizhen Lin. (2008) Interleukin-10 is an Essential Modulator of Mucoid Metaplasia in a Mouse Otitis Media Model. Annals of Otology, Rhinology & Laryngology 117:8, pages 630-636.
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Carol J. MacArthur, Steven H. Hefeneider, J Beth Kempton & Dennis R. Trune. (2009) C3H/HeJ Mouse Model for Spontaneous Chronic Otitis Media. The Laryngoscope 116:7, pages 1071-1079.
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Charles D. Bluestone, Cuneyt M. Alper, Craig A. Buchman, Jens U. Felding, Samir N. Ghadiali, Patricia A. Hebda, Isamu Sando, Sven-Eric Stangerup, J. Douglas Swarts & Haruo Takahashi. (2016) 2. Eustachian Tube, Middle Ear, and Mastoid Anatomy; Physiology, Pathophysiology, and Pathogenesis. Annals of Otology, Rhinology & Laryngology 114:1_suppl, pages 16-30.
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David J. Lim, Ann Hermansson, Sten O. HellstrÖ, Burkhard Hussl, Cuneyt M. Alper, Yukiko Uno, Ali Andalibi, Timothy T. K. Jung, Lauren O. Bakaletz, Hideyuki Kawauchi, Craig A. Buchman, Joseph Kerschner, Per Cayé-Thomasen, Jizhen Lin, Richard A. Chole, Saumil N. Merchant, Philippe Herman, Haa-Yung Lee, Sung-Ho Kang & Michael M. Paparella. (2021) 3. Animal Models; Anatomy and Pathology; Pathogenesis; Cell Biology and Genetics. Annals of Otology, Rhinology & Laryngology 114:1_suppl, pages 31-41.
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Katsuhiro Toyama, Michael M. Paparella, Youngki Kim & Jizhen Lin. (2016) Temperature-Sensitive Sv40-Immortalized Rat Middle Ear Epithelial Cells. Annals of Otology, Rhinology & Laryngology 113:12, pages 967-974.
Crossref
Jizhen Lin, Yasuhiro Tsuboi, Wei Pan, G.Scott Giebink, George L. Adams & Youngki Kim. (2002) Analysis by cDNA microarrays of altered gene expression in middle ears of rats following pneumococcal infection. International Journal of Pediatric Otorhinolaryngology 65:3, pages 203-211.
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