59
Views
59
CrossRef citations to date
0
Altmetric
Original Paper

Protective effects of α-tocopherol and tiopronin against cisplatin-induced ototoxicity

, , , &
Pages 421-426 | Received 16 Sep 2003, Accepted 02 Oct 2003, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Anna Rita Fetoni & Laura Astolfi. (2020) Cisplatin ototoxicity and role of antioxidant on its prevention. Hearing, Balance and Communication 18:4, pages 234-241.
Read now
Feng-Jun Qin, Xiao-Hua Hu, Zhong Chen, Xu Chen & Yu-Ming Shen. (2019) Protective effects of tiopronin against oxidative stress in severely burned patients. Drug Design, Development and Therapy 13, pages 2827-2832.
Read now
Anna Rita Fetoni, Sara Eramo, Diana Troiani & Gaetano Paludetti. (2011) Therapeutic window for ferulic acid protection against noise-induced hearing loss in the guinea pig. Acta Oto-Laryngologica 131:4, pages 419-427.
Read now
Sathiyaseelan Theneshkumar & Stavros Hatzopoulos. (2007) Pharmacological otoprotection strategies against cisplatin-induced ototoxicity. Audiological Medicine 5:3, pages 154-159.
Read now
Steven Attia & George Wilding. (2006) Novel antioxidant technology for prostate cancer chemoprevention and treatment. Expert Opinion on Therapeutic Patents 16:9, pages 1255-1267.
Read now

Articles from other publishers (54)

Anna Pisani, Fabiola Paciello, Raffaele Montuoro, Rolando Rolesi, Jacopo Galli & Anna Rita Fetoni. (2023) Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic. Life 13:4, pages 1035.
Crossref
Xiaorong Niu, Peng Han, Junsong Liu, Zichen Chen, Ting Zhang, Baiya Li, Xiaoyan Ma, Qun Wu & Xudong Ma. (2023) Regulation of PPARγ/CPT-1 expression ameliorates cochlear hair cell injury by regulating cellular lipid metabolism and oxidative stress. Molecular Genetics and Genomics 298:2, pages 473-483.
Crossref
Fabiola Paciello, Cristian Ripoli, Anna Rita Fetoni & Claudio Grassi. (2023) Redox Imbalance as a Common Pathogenic Factor Linking Hearing Loss and Cognitive Decline. Antioxidants 12:2, pages 332.
Crossref
Anna Rita Fetoni, Fabiola PacielloDiana Troiani. (2022) Cisplatin Chemotherapy and Cochlear Damage: Otoprotective and Chemosensitization Properties of Polyphenols. Antioxidants & Redox Signaling 36:16-18, pages 1229-1245.
Crossref
R Bademci, MA Erdoğan, E Eroğlu, A Meral, A Erdoğan, Ö Atasoy & O Erbaş. (2021) Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity. Human & Experimental Toxicology 40:12, pages 2178-2187.
Crossref
Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu & Aimei Wang. (2020) Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling. International Journal of Molecular Medicine 46:2, pages 806-816.
Crossref
Alberto Romano, Michele Antonio Capozza, Stefano Mastrangelo, Palma Maurizi, Silvia Triarico, Rolando Rolesi, Giorgio Attinà, Anna Rita Fetoni & Antonio Ruggiero. (2020) Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer. Cancers 12:5, pages 1266.
Crossref
Maria Perde-Schrepler, Eva Fischer-Fodor, Piroska Virag, Ioana Brie, Mihai Cenariu, Cristian Pop, Angela Valcan, Eugen Gurzau & Alma Maniu. (2020) The expression of copper transporters associated with the ototoxicity induced by platinum-based chemotherapeutic agents. Hearing Research 388, pages 107893.
Crossref
Gaëlle Naert, Marie-Pierre Pasdelou & Colleen G. Le Prell. (2019) Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise. The Journal of the Acoustical Society of America 146:5, pages 3743-3769.
Crossref
Bahareh Hakiminia, Arash Goudarzi & Azadeh Moghaddas. (2019) Has vitamin E any shreds of evidence in cisplatin‐induced toxicity. Journal of Biochemical and Molecular Toxicology 33:8.
Crossref
Nesibe Gül Yüksel Aslıer, Aylin Altınışık Tağaç, Serpil Mungan Durankaya, Meryem Çalışır, Nevin Ersoy, Günay Kırkım, Kadir Yurdakoç, Hüsnü Alper Bağrıyanık, Osman Yılmaz, Semih Sütay & Enis Alpin Güneri. (2019) Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model. International Journal of Pediatric Otorhinolaryngology 122, pages 60-69.
Crossref
M. N. Peter, G. Paasche, U. Reich, T. Lenarz & A. Warnecke. (2019) Reaktionen im Corti-Organ auf elektrische StimulationReactions in the organ of Corti to electrical stimulation. HNO 67:4, pages 251-257.
Crossref
Samson Jamesdaniel. 2018. Inflammatory Mechanisms in Mediating Hearing Loss. Inflammatory Mechanisms in Mediating Hearing Loss 15 30 .
Jin Ho Lee, Se Heang Oh, Tae Ho Kim, Yoon Young Go & Jae-Jun Song. (2017) Anti-apoptotic effect of dexamethasone in an ototoxicity model. Biomaterials Research 21:1.
Crossref
Marijana Sekulic-Jablanovic, Vesna Petkovic, Matthew B. Wright, Krystsina Kucharava, Nathan Huerzeler, Soledad Levano, Yves Brand, Katharina Leitmeyer, Andrea Glutz, Alexander Bausch & Daniel Bodmer. (2017) Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress. PLOS ONE 12:11, pages e0188596.
Crossref
Shigang Shen, Xueru Chi, Jingran Dong, Shuying Huo, Hongwu Tian, Liyao Xu & Tiesheng Shi. (2017) Oxidation of the drug tiopronin by Cerium(IV) in perchloric acid media: Kinetic and mechanistic analyses. Journal of Molecular Liquids 246, pages 1-6.
Crossref
Burak Taş & Gökçe Şimşek. (2017) SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 19:1, pages 30-30.
Crossref
Laura Astolfi, Edi Simoni, Filippo Valente, Sara Ghiselli, Stavros Hatzopoulos, Milvia Chicca & Alessandro Martini. (2016) Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats. PLOS ONE 11:9, pages e0162106.
Crossref
Sung Kyun Kim, Gi Jung Im, Yun Suk An, Se Hee Lee, Hak Hyun Jung & Sang Yoo Park. (2016) The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. International Journal of Pediatric Otorhinolaryngology 86, pages 9-14.
Crossref
Kari L. Green, Donald L. Swiderski, Diane M. Prieskorn, Susan J. DeRemer, Lisa A. Beyer, Josef M. Miller, Glenn E. Green & Yehoash Raphael. (2016) ACEMg Diet Supplement Modifies Progression of Hereditary Deafness. Scientific Reports 6:1.
Crossref
Romina Castañeda-Arriaga, Annik Vivier-Bunge & J. Raul Alvarez-Idaboy. (2016) Primary antioxidant and metal-binding effects of tiopronin: A theoretical investigation of its action mechanism. Computational and Theoretical Chemistry 1077, pages 48-57.
Crossref
A.R. Fetoni, A. Ruggiero, D. Lucidi, E. De Corso, B. Sergi, G. Conti & G. Paludetti. (2016) Audiological Monitoring in Children Treated with Platinum Chemotherapy. Audiology and Neurotology 21:4, pages 203-211.
Crossref
Xiaohui Bai, Chi Zhang, Aiping Chen, Wenwen Liu, Jianfeng Li, Qian Sun & Haibo Wang. (2016) Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plasticity 2016, pages 1-10.
Crossref
M.R. Vasko, B. Shariati & N. Zanville. 2016. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy 383 428 .
Lohith Shivappa, Ganga Huvin, Harish Chandra Goel & Surender Kumar Morodia. (2015) EVALUATION OF OTOPROTECTIVE EFFECT OF ANTIOXIDANT SUPPLEMENTATION WITH VITAMIN E ON SENSORINEURAL HEARING LOSS IN PATIENTS TREATED WITH CISPLATIN CONCURRENT CHEMORADIOTHERAPY FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA. Journal of Evolution of Medical and Dental Sciences 4:98, pages 16347-16349.
Crossref
Muneeb U. Rehman, Nemat Ali, Summya Rashid, Tyan Jain, Sana Nafees, Mir Tahir, Abdul Quaiyoom Khan, Abdul Lateef, Rehan Khan, Oday O. Hamiza, Syed Kazim, Wajhul Qamar & Sarwat Sultana. (2014) Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of oxidative and inflammatory markers. Pharmacological Reports 66:6, pages 1050-1059.
Crossref
Anna Rita Fetoni, Wanda Lattanzi, Sara Letizia Maria Eramo, Marta Barba, Fabiola Paciello, Chiara Moriconi, Rolando Rolesi, Fabrizio Michetti, Diana Troiani & Gaetano Paludetti. (2014) Grafting and Early Expression of Growth Factors from Adipose-Derived Stem Cells Transplanted into the Cochlea, in a Guinea Pig Model of Acoustic Trauma. Frontiers in Cellular Neuroscience 8.
Crossref
Anna R. Fetoni, Sara L. M. Eramo, Fabiola Paciello, Rolando Rolesi, Maria Vittoria Podda, Diana Troiani & Gaetano Paludetti. (2014) Curcuma Longa (Curcumin) Decreases In Vivo Cisplatin-Induced Ototoxicity Through Heme Oxygenase-1 Induction. Otology & Neurotology 35:5, pages e169-e177.
Crossref
Shuying Huo, Hongmei Shi, Dongzhi Liu, Shigang Shen, Jiong Zhang, Changying Song & Tiesheng Shi. (2013) Kinetics and mechanism of reactions of the drug tiopronin with platinum(IV) complexes. Journal of Inorganic Biochemistry 125, pages 9-15.
Crossref
Tong Ho Kang, Bin Na Hong, Su-Young Jung, Jeong-Han Lee, Hong-Seob So, Raekil Park & Yong-Ouk You. (2013) Curculigo orchioides Protects Cisplatin-Induced Cell Damage . The American Journal of Chinese Medicine 41:02, pages 425-441.
Crossref
Eric C. Bielefeld, Chiemi Tanaka, Guang-di Chen, Donald Coling, Manna Li, Donald Henderson & Anna R. Fetoni. (2013) An Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. Anti-Cancer Drugs 24:1, pages 43-51.
Crossref
Penelope R. BrockKristin R. KnightDavid R. FreyerKathleen C.M. CampbellPeter S. SteygerBrian W. BlakleyShahrad R. RassekhKay W. ChangBrian J. FligorKaukab RajputMichael SullivanEdward A. Neuwelt. (2012) Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale. Journal of Clinical Oncology 30:19, pages 2408-2417.
Crossref
A Naqshbandi, W Khan, S Rizwan & F Khan. (2012) Studies on the protective effect of flaxseed oil on cisplatin-induced hepatotoxicity. Human & Experimental Toxicology 31:4, pages 364-375.
Crossref
Caglar Calli, Ercan Pinar, Semih Oncel, H. Alper Bagriyanik & E. Umut Sakarya. (2011) Recovery of Hearing in Cisplatin-Induced Ototoxicity in the Guinea Pig with Intratympanic Dexamethasone. Indian Journal of Otolaryngology and Head & Neck Surgery 64:1, pages 46-50.
Crossref
Kilarkaje Narayana, Maie Al-Bader, Alyaa Mousa & Khalid M. Khan. (2012) Molecular effects of chemotherapeutic drugs and their modulation by antioxidants in the testis. European Journal of Pharmacology 674:2-3, pages 207-216.
Crossref
Patrizia FerroniDavid Della-MorteRaffaele PalmirottaMark McClendonGianluca TestaPasquale AbeteFranco RengoTatjana RundekFiorella GuadagniMario Roselli. (2011) Platinum-Based Compounds and Risk for Cardiovascular Toxicity in the Elderly: Role of the Antioxidants in Chemoprevention. Rejuvenation Research 14:3, pages 293-308.
Crossref
Paolo Enrico & Ron Goodey. 2011. Textbook of Tinnitus. Textbook of Tinnitus 343 361 .
J.S. Lee, S.U. Kang, H.S. Hwang, J.H. Pyun, Y.H. Choung & C.H. Kim. (2010) Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK. Toxicology Letters 199:3, pages 308-316.
Crossref
A.R. Fetoni, C. Mancuso, S.L.M. Eramo, M. Ralli, R. Piacentini, E. Barone, G. Paludetti & D. Troiani. (2010) In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig. Neuroscience 169:4, pages 1575-1588.
Crossref
Hyeon-Hee Yu, Su-Young Jung, Mee-Kyung Shin, Raekil Park, Hong-Seob So & Yong-Ouk You. (2010) Pueraria thunbergiana inhibits cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals . Phytotherapy Research 24:6, pages 834-839.
Crossref
A.L. Poirrier, P. Van den Ackerveken, T.S. Kim, R. Vandenbosch, L. Nguyen, P.P. Lefebvre & B. Malgrange. (2010) Ototoxic drugs: Difference in sensitivity between mice and guinea pigs. Toxicology Letters 193:1, pages 41-49.
Crossref
Sung-Il NamDae-Kyu SongSung-Hee ParkJae-Hoon LeeWoo-Keun LeeEal-Maan KimJae-Sik Park. (2009) Characterization of Gentamicin-Induced Apoptosis in a Cochlear Cell Model. Korean Journal of Otolaryngology-Head and Neck Surgery 52:3, pages 207.
Crossref
Hyeon-Hee Yu, Jong-Moon Hur, Se-Jeong Seo, Hae-Dalma Moon, Hyun-Jin Kim, Rae-Kil Park & Yong-Ouk You. (2012) Protective Effect of Ursolic Acid from Cornus officinalis on the Hydrogen Peroxide-Induced Damage of HEI-OC1 Auditory Cells . The American Journal of Chinese Medicine 37:04, pages 735-746.
Crossref
Anna R. Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini & Diana Troiani. (2008) Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E. NeuroReport 19:3, pages 277-281.
Crossref
Peter Kovacic & Ratnasamy Somanathan. (2008) Ototoxicity and noise trauma: Electron transfer, reactive oxygen species, cell signaling, electrical effects, and protection by antioxidants: Practical medical aspects. Medical Hypotheses 70:5, pages 914-923.
Crossref
Richard J. Salvi. 2008. Hair Cell Regeneration, Repair, and Protection. Hair Cell Regeneration, Repair, and Protection 1 37 .
Xinyan Huang, Craig A. Whitworth & Leonard P. Rybak. (2007) Ginkgo Biloba Extract (EGb 761) Protects Against Cisplatin-Induced Ototoxicity in Rats. Otology & Neurotology 28:6, pages 828-833.
Crossref
Yao-Ching Hung, G. Steven Huang, Li-Wei Lin, Meng-Yen Hong & Pei-San Se. (2007) Thea sinensis melanin prevents cisplatin-induced nephrotoxicity in mice. Food and Chemical Toxicology 45:7, pages 1123-1130.
Crossref
Cara A. Rabik & M. Eileen Dolan. (2007) Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treatment Reviews 33:1, pages 9-23.
Crossref
Hiroaki Shimogori, Tsuyoshi Takemoto, Takefumi Mikuriya & Hiroshi Yamashita. (2007) Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (±)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid. European Journal of Pharmacology 554:2-3, pages 223-228.
Crossref
Hyeon-Hee Yu, Se-Jeong Seo, Yeon-Hwa Kim, Hae-Youn Lee, Rae-Kil Park, Hong-Seob So, Seon ll Jang & Yong-Ouk You. (2006) Protective effect of Rehmannia glutinosa on the cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals. Journal of Ethnopharmacology 107:3, pages 383-388.
Crossref
Bruno Sergi, Anna Rita Fetoni, Gaetano Paludetti, Aldo Ferraresi, Pierluigi Navarra, Alvaro Mordente & Diana Troiani. (2006) Protective properties of idebenone in noise-induced hearing loss in the guinea pig. NeuroReport 17:9, pages 857-861.
Crossref
Leonard P. Rybak & Craig A. Whitworth. (2005) Ototoxicity: therapeutic opportunities. Drug Discovery Today 10:19, pages 1313-1321.
Crossref
M. Tariq, H. A. Khan, K. Al Moutaery & S. Al Deeb. (2004) Sodium benzoate attenuates iminodipropionitrile-induced behavioral syndrome in rats. Behavioural Pharmacology 15:8, pages 585-588.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.