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Research Article

Vascular Endothelial Growth Factor (VEGF) and Microvessel Density in Squamous Cell Carcinomas of the Larynx: an Immunohistochemical Study

Pages 732-738 | Published online: 08 Jul 2009

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Izabela Bronikowska, Elzbieta Swietochowska, Robert Morawski, Pawel Sowa & Eugeniusz Czecior. (2022) Concentration of hypoxia-inducible factor-1, glucose transporter 1 and vascular endothelial growth factor in tissue samples and serum in patients with primary laryngeal carcinoma. Acta Oto-Laryngologica 142:6, pages 532-536.
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John G Devlin & Corey J Langer. (2007) Combined modality treatment of laryngeal squamous cell carcinoma. Expert Review of Anticancer Therapy 7:3, pages 331-350.
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Hiroshi Shigyo, Satoshi Nonaka, Akihiro Katada, Nobuyuki Bandoh, Takeshi Ogino, Akihiro Katayama, Miki Takahara, Tatsuya Hayashi & Yasuaki Harabuchi. (2007) Inducible nitric oxide synthase expression in various laryngeal lesions in relation to carcinogenesis, angiogenesis, and patients’ prognosis. Acta Oto-Laryngologica 127:9, pages 970-979.
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Hjalmar G. Hagedorn, Andreas G. Nerlich. (2000) Microvessel Density and Endothelial Basement Membrane Composition in Laryngeal Squamous Cell Carcinomas. Acta Oto-Laryngologica 120:7, pages 891-898.
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Articles from other publishers (30)

Barbora Peltanova, Martina Raudenska & Michal Masarik. (2019) Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Molecular Cancer 18:1.
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Anke Schlüter, Patrick Weller, Oliver Kanaan, Ivonne Nel, Lukas Heusgen, Benedikt Höing, Pia Haßkamp, Sebastian Zander, Magis Mandapathil, Nina Dominas, Judith Arnolds, Boris A. Stuck, Stephan Lang, Agnes Bankfalvi & Sven Brandau. (2018) CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma. BMC Cancer 18:1.
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Caroline Brandi Schlaepfer Sales, Marcilei Eliza Cavichiolli Buim, Renata Oliveira de Souza, Ludmila de Faro Valverde, Maria Cecília Mathias Machado, Mitermayer Galvão Reis, Fernando Augusto Soares, Eduardo Antônio Gonçalves Ramos & Clarissa Araújo Gurgel Rocha. (2016) Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study. Journal of Oral Pathology & Medicine 45:7, pages 481-485.
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Hui-Hsin Ko, Jang-Jaer Lee, Hsin-Ming Chen, Sang-Heng Kok, Mark Yen-Ping Kuo, Shih-Jung Cheng & Chun-Pin Chiang. (2015) Upregulation of vascular endothelial growth factor mRNA level is significantly related to progression and prognosis of oral squamous cell carcinomas. Journal of the Formosan Medical Association 114:7, pages 605-611.
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Carlos Alberto de Carvalho Fraga, Lucyana Conceição Farias, Marcos Vinícius Macedo de Oliveira, Patrícia Luciana Batista Domingos, Camila Santos Pereira, Thiago Fonseca Silva, Ashbeel Roy, Ricardo Santiago Gomez, Alfredo Maurício Batista de Paula & André Luiz Sena Guimarães. (2014) Increased VEGFR2 and MMP9 protein levels are associated with epithelial dysplasia grading. Pathology - Research and Practice 210:12, pages 959-964.
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Monika E. Freiser, Paolo Serafini & Donald T. Weed. (2013) The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities. Immunologic Research 57:1-3, pages 52-69.
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Andrea Bolzoni Villaret, Diego Barbieri, Giorgio Peretti, Alberto Schreiber, Simona Fisogni, Silvia Lonardi, Fabio Facchetti & Piero Nicolai. (2013) Angiogenesis and lymphangiogenesis in early-stage laryngeal carcinoma: Prognostic implications. Head & Neck 35:8, pages 1132-1137.
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Shih-Jung Cheng, Jang-Jaer Lee, Sang-Heng Kok, Chia-Hsuan Chou, Hao-Hueng Chang, Hsiang Yang, Meng-Ling Chiang & Mark Yen-Ping Kuo. (2011) Expression of Vascular Endothelial Growth Factor is Significantly Associated With Progression and Prognosis of Oral Squamous Cell Carcinomas in Taiwan. Journal of the Formosan Medical Association 110:1, pages 50-57.
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Anaëlle Duray, Stéphanie Demoulin, Pascale Hubert, Philippe Delvenne & Sven Saussez. (2010) Immune Suppression in Head and Neck Cancers: A Review. Clinical and Developmental Immunology 2010, pages 1-15.
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Zeynep Nil Ünal, Murat Ünal, Özlen Tubay Bağdatoğlu, Gürbüz Polat & Uğur Atik. (2008) Genetic Polymorphism of VEGF-1154 (A/G) in Laryngeal Squamous Cell Carcinoma. Archives of Medical Research 39:2, pages 209-211.
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Young-Wook Park. (2007) Poster 068: Expressions of Tumor Growth and Angiogenic Signaling Molecules in Adenoid Cystic Carcinomas of Human Salivary Glands. Journal of Oral and Maxillofacial Surgery 65:9, pages 43.e42.
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S. Johnstone & R.M. Logan. (2007) Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery 36:3, pages 263-266.
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Rahul R. Parikh, Qifeng Yang & Bruce G. Haffty. (2006) Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy. Cancer 109:3, pages 566-573.
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C Onesto, J-M Hannoun-Lévi, E Chamorey, J-L Formento, A Ramaioli & G Pagès. (2006) Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance. British Journal of Cancer 94:10, pages 1516-1523.
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Chih‐Yen Chien, Chih‐Ying Su, Chung‐Feng Hwang, Hui‐Ching Chuang, Yea‐Chyang Hsiao, Shu‐Ling Wu & Chao‐Cheng Huang. (2005) Clinicopathologic significance of CD105 expression in squamous cell carcinoma of the hypopharynx. Head & Neck 28:5, pages 441-446.
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Dawei Sun, Yanjun Wang, Weijia Kong & Banghua Liu. (2006) Prognostic value of Ki67 and VEGF expression in laryngeal squamous cell carcinoma. Chinese Journal of Clinical Oncology 3:1, pages 20-24.
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Boban M. Erovic, Martina Pelzmann, Matthäus Ch. Grasl, Johannes Pammer, Gabriela Kornek, Werner Brannath, Edgar Selzer & Dietmar Thurnher. (2005) Mcl-1, Vascular Endothelial Growth Factor-R2, and 14-3-3σ Expression Might Predict Primary Response against Radiotherapy and Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck. Clinical Cancer Research 11:24, pages 8632-8636.
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Da-wei Sun, Yan-jun Wang, Wei-jia Kong & Bang-hua Liu. (2005) A correlative study of Ki67 and vascular endothelial growth factor and their value in laryngeal squamous cell carcinoma. Chinese Journal of Cancer Research 17:4, pages 235-240.
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Konstantinos Vlachtsis, Angelos Nikolaou, Konstantinos Markou, George Fountzilas & Ioannis Daniilidis. (2005) Clinical and molecular prognostic factors in operable laryngeal cancer. European Archives of Oto-Rhino-Laryngology 262:11, pages 890-898.
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Panayiotis A Kyzas, Dimitrios Stefanou, Anna Batistatou & Niki J Agnantis. (2005) Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology 131:9, pages 624-630.
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Young Wook Park, Maher N. Younes, Samar A. Jasser, Orhan G. Yigitbasi, Ge Zhou, Corazon D. Bucana, Benjamin N. Bekele & Jeffrey N. Myers. (2005) AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice. Clinical Cancer Research 11:5, pages 1963-1973.
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Panayiotis A. Kyzas, Isabella W. Cunha & John P.A. Ioannidis. (2005) Prognostic Significance of Vascular Endothelial Growth Factor Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis. Clinical Cancer Research 11:4, pages 1434-1440.
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P.A. Kyzas, D. Stefanou & N.J. Agnantis. (2004) Immunohistochemical expression of vascular endothelial growth factor correlates with positive surgical margins and recurrence in T1 and T2 squamous cell carcinoma (SCC) of the lower lip. Oral Oncology 40:9, pages 941-947.
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Nobuyuki Bandoh, Tatsuya Hayashi, Miki Takahara, Kan Kishibe, Takeshi Ogino, Akihiro Katayama, Masanobu Imada, Satoshi Nonaka & Yasuaki Harabuchi. (2004) VEGF and bFGF expression and microvessel density of maxillary sinus squamous cell carcinoma in relation to p53 status, spontaneous apoptosis and prognosis. Cancer Letters 208:2, pages 215-225.
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Veera Näyhä, Jaakko Laitakari & Frej Stenbäck. (2016) Stage-Dependent Expression of an Angiogenic Agent and Vascular Organization in Experimental Skin Tumor Development. Toxicologic Pathology 31:5, pages 539-548.
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Csilla Neuchrist, Bohan M. Erovic, Allesandra Handisurya, Michael B. Fischer, Georg E. Steiner, David Hollemann, Claudia Gedlicka, A. Saaristo & Martin Burian. (2003) Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck. Head & Neck 25:6, pages 464-474.
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Shu Zheng. (2003) Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma. World Journal of Gastroenterology 9:6, pages 1227.
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J.J. Homer, J. Greenman & N.D. Stafford. (2001) The expression of vascular endothelial growth factor (VEGF) and VEGF-C in early laryngeal cancer: relationship with radioresistance. Clinical Otolaryngology and Allied Sciences 26:6, pages 498-504.
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Csilla Neuchrist, Boban M. Erovic, Alessandra Handisurya, Georg E. Steiner, Patricia Rockwell, Claudia Gedlicka & Martin Burian. (2001) Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Expression in Squamous Cell Carcinomas of the Head and Neck. The Laryngoscope 111:10, pages 1834-1841.
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H.H. Sedlacek. (2001) Pharmacological aspects of targeting cancer gene therapy to endothelial cells. Critical Reviews in Oncology/Hematology 37:3, pages 169-215.
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