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Research Article

Children with Untreated Food Allergy Express a Relative Increment in the Density of Duodenal ?d+ T Cells

Pages 1137-1142 | Published online: 08 Jul 2009

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Read on this site (3)

Pasquale Mansueto, Aurelio Seidita, Alberto D’Alcamo & Antonio Carroccio. (2014) Non-Celiac Gluten Sensitivity: Literature Review. Journal of the American College of Nutrition 33:1, pages 39-54.
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M Arvonen, M Tikanmäki, P Vähäsalo & TJ Karttunen. (2010) Heat shock protein expression is low in intestinal mucosa in juvenile idiopathic arthritis: a defect in immunoregulation?. Scandinavian Journal of Rheumatology 39:3, pages 212-218.
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Merja T. Augustin, Jorma Kokkonen & Tuomo J. Karttunen. (2005) Duodenal cytotoxic lymphocytes in cow's milk protein sensitive enteropathy and coeliac disease. Scandinavian Journal of Gastroenterology 40:12, pages 1398-1406.
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Articles from other publishers (60)

Carlota García-Hoz, Laura Crespo, Roberto Pariente, Ana De Andrés, Rafael Rodríguez-Ramos & Garbiñe Roy. (2024) Intraepithelial Lymphogram in the Diagnosis of Celiac Disease in Adult Patients: A Validation Cohort. Nutrients 16:8, pages 1117.
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Sen Yagi, Shinya Furukawa, Seiyuu Suzuki, Katsuhisa Ohashi, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda & Yoichi Hiasa. (2024) No Association Between Allergic Diseases and Constipation in Japanese Ulcerative Colitis Patients: A Cross-Sectional Study. Cureus.
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Esther Dawen Yu, Eric Wang, Emily Garrigan, Aaron Sutherland, Natalie Khalil, Kendall Kearns, John Pham, Veronique Schulten, Bjoern Peters, April Frazier, Alessandro Sette & Ricardo da Silva Antunes. (2022) Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors. Cell Reports Methods 2:12, pages 100350.
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Cristina Camarero, Ana De AndrésCarlota García-HozBelén RoldánAlfonso MurielFrancisco LeónGarbiñe Roy. (2021) Assessment of Duodenal Intraepithelial Lymphocyte Composition (Lymphogram) for Accurate and Prompt Diagnosis of Celiac Disease in Pediatric Patients. Clinical and Translational Gastroenterology 12:11, pages e00426.
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Ian Brown & Michael B. Wallace. 2021. Gastrointestinal Pathology. Gastrointestinal Pathology 161 194 .
Pablo Ruiz-Ramírez, Gerard Carreras, Ingrid Fajardo, Eva Tristán, Anna Carrasco, Isabel Salvador, Yamile Zabana, Xavier Andújar, Carme Ferrer, Diana Horta, Carme Loras, Roger García-Puig, Fernando Fernández-Bañares & Maria Esteve. (2021) Intraepithelial Lymphocyte Cytometric Pattern Is a Useful Diagnostic Tool for Coeliac Disease Diagnosis Irrespective of Degree of Mucosal Damage and Age—A Validation Cohort. Nutrients 13:5, pages 1684.
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Marcela de Lima Moreira, Michael N. T. Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G. Pellicci & Sidonia B. G. Eckle. (2020) Hypersensitivities following allergen antigen recognition by unconventional T cells. Allergy 75:10, pages 2477-2490.
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Umberto Volta, Giacomo Caio, Caterina Ghirardi, Lisa Lungaro, Pasquale Mansueto, Antonio Carroccio & Roberto De Giorgio. (2020) Minimal Lesions of the Small Intestinal Mucosa: More than Morphology. Digestive Diseases and Sciences 65:10, pages 2761-2768.
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Murat Cakir, Elif Sag, Ismail Saygin & Fazil Orhan. (2020) Ileocolonic Lymphonodular Hyperplasia in Children Related to Etiologies Ranging from Food Hypersensitivity to Familial Mediterranean Fever. Medical Principles and Practice 29:5, pages 473-479.
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Ian Brown. 2019. Endoscopic Biopsy Interpretation. Endoscopic Biopsy Interpretation 191 214 .
Julio Valle, José Mario T Morgado, Juan Ruiz‐Martín, Antonio Guardiola, Miriam Lopes‐Nogueras, Almudena García‐Vela, Beatriz Martín‐Sacristán & Laura Sánchez‐Muñoz. (2017) Flow cytometry of duodenal intraepithelial lymphocytes improves diagnosis of celiac disease in difficult cases. United European Gastroenterology Journal 5:6, pages 819-826.
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Miika Arvonen, Lauri J. Virta, Tytti Pokka, Liisa Kröger & Paula Vähäsalo. (2017) Cow's Milk Allergy in Infancy and Later Development of Juvenile Idiopathic Arthritis: A Register-Based Case-Control Study. American Journal of Epidemiology 186:2, pages 237-244.
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Scott R. Owens, Cathryn J. Lapedis & Joel K. Greenson. (2017) Coeliac disease and other intraepithelial lymphocytic disorders of the upper gastrointestinal tract. Diagnostic Histopathology 23:2, pages 62-72.
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Consolato Sergi, Fan Shen & Gerd Bouma. (2017) Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease). World Journal of Gastroenterology 23:4, pages 573.
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Gregory Y Lauwers, Alessio Fasano & Ian S Brown. (2015) Duodenal lymphocytosis with no or minimal enteropathy: much ado about nothing?. Modern Pathology 28, pages S22-S29.
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Fernando Fernández-Bañares, Anna Carrasco, Roger García-Puig, Mercè Rosinach, Clarisa González, Montserrat Alsina, Carme Loras, Antonio Salas, Josep M. Viver & Maria Esteve. (2014) Intestinal Intraepithelial Lymphocyte Cytometric Pattern Is More Accurate than Subepithelial Deposits of Anti-Tissue Transglutaminase IgA for the Diagnosis of Celiac Disease in Lymphocytic Enteritis. PLoS ONE 9:7, pages e101249.
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Ashraf Uzzaman & Hirsh D. Komarow. 2013. Food Allergy. Food Allergy 31 46 .
Silvia Lonardi, Vincenzo Villanacci, Luisa Lorenzi, Alberto Lanzini, Francesco Lanzarotto, Nice Carabellese, Umberto Volta & Fabio Facchetti. (2013) Anti-TCR gamma antibody in celiac disease: the value of count on formalin-fixed paraffin-embedded biopsies.. Virchows Archiv 463:3, pages 409-413.
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Ian Brown. 2013. Morson and Dawson's Gastrointestinal Pathology. Morson and Dawson's Gastrointestinal Pathology 373 396 .
M Arvonen, P Vähäsalo, S Turunen, H M Salo, M Mäki, K Laurila, O Vaarala & T J Karttunen. (2012) Altered expression of intestinal human leucocyte antigen D-related and immune signalling molecules in juvenile idiopathic arthritis. Clinical and Experimental Immunology 170:3, pages 266-273.
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P. Mansueto, G. Iacono, A. Seidita, A. D'Alcamo, D. Sprini & A. Carroccio. (2012) Review article: intestinal lymphoid nodular hyperplasia in children – the relationship to food hypersensitivity. Alimentary Pharmacology & Therapeutics 35:9, pages 1000-1009.
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Tuomo S. Kokkonen, Merja T. Augustin, Jorma Kokkonen, Riitta Karttunen & Tuomo J. Karttunen. (2012) Serum and Tissue CD23, IL‐15, and FasL in Cow's‐Milk Protein–sensitive Enteropathy and in Coeliac Disease. Journal of Pediatric Gastroenterology and Nutrition 54:4, pages 525-531.
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Abdulrahman Al-Hussaini, Mosa Khormi & Mosa Fagih. (2012) Duodenal bulb nodularity: an endoscopic sign of cow's milk protein allergy in infants?. Gastrointestinal Endoscopy 75:2, pages 450-453.
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Josefa Melero Ruiz, Montserrat García Cerrada, María Luisa Vargas Pérez, José Juan Fernández de Mera, María Isabel Muñoz Sanjuán, Cristina González Roíz & Emilio Doblaré Castellano. (2011) Utilidad del recuento e inmunofenotipaje de los linfocitos intraepiteliales de la mucosa intestinal en el diagnóstico de la enfermedad celiaca. Revista del Laboratorio Clínico 4:1, pages 15-22.
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Francisco Leon. (2011) Flow cytometry of intestinal intraepithelial lymphocytes in celiac disease. Journal of Immunological Methods 363:2, pages 177-186.
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Outi Koskinen, Pekka Collin, Katri Lindfors, Kaija Laurila, Markku Mäki & Katri Kaukinen. (2010) Usefulness of Small-bowel Mucosal Transglutaminase-2 Specific Autoantibody Deposits in the Diagnosis and Follow-up of Celiac Disease. Journal of Clinical Gastroenterology 44:7, pages 483-488.
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Mia Westerholm‐Ormio, Outi Vaarala, Minna Tiittanen & Erkki Savilahti. (2010) Infiltration of Foxp3‐ and Toll‐like Receptor‐4–positive Cells in the Intestines of Children With Food Allergy. Journal of Pediatric Gastroenterology and Nutrition 50:4, pages 367-376.
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Riccardo Troncone & Valentina Discepolo. (2009) Colon in Food Allergy. Journal of Pediatric Gastroenterology and Nutrition 48:S2.
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Alberto Finamore, Marianna Roselli, Serena Britti, Giovanni Monastra, Roberto Ambra, Aida Turrini & Elena Mengheri. (2008) Intestinal and Peripheral Immune Response to MON810 Maize Ingestion in Weaning and Old Mice. Journal of Agricultural and Food Chemistry 56:23, pages 11533-11539.
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Scott R. Owens & Joel K. Greenson. (2008) Coeliac disease and other intraepithelial lymphocytic disorders of the upper gastrointestinal tract. Diagnostic Histopathology 14:9, pages 419-426.
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Susan S. Percival, Jack F. Bukowski & John Milner. (2008) Bioactive Food Components that Enhance γδ T Cell Function May Play a Role in Cancer Prevention. The Journal of Nutrition 138:1, pages 1-4.
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Anna M. Russano, Gabrio Bassotti, Elisabetta Agea, Onelia Bistoni, Alessandro Mazzocchi, Antonio Morelli, Steven A. Porcelli & Fabrizio Spinozzi. (2007) CD1-Restricted Recognition of Exogenous and Self-Lipid Antigens by Duodenal γδ+ T Lymphocytes. The Journal of Immunology 178:6, pages 3620-3626.
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Giuseppe Iacono, Alberto Ravelli, Lidia Di Prima, Calogero Scalici, Stefania Bolognini, Sara Chiappa, Giuseppe Pirrone, Giuseppina Licastri & Antonio Carroccio. (2007) Colonic Lymphoid Nodular Hyperplasia in Children: Relationship to Food Hypersensitivity. Clinical Gastroenterology and Hepatology 5:3, pages 361-366.
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Cristina Camarero, Francisco Leon, Laura Sanchez, Angel Asensio & Garbiñe Roy. (2007) Age-Related Variation of Intraepithelial Lymphocytes Subsets in Normal Human Duodenal Mucosa. Digestive Diseases and Sciences 52:3, pages 685-691.
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Eva Untersmayr & Erika Jensen-Jarolim. (2006) Mechanisms of type I food allergy. Pharmacology & Therapeutics 112:3, pages 787-798.
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A. CARROCCIO & G. IACONO. (2006) Review article: chronic constipation and food hypersensitivity – an intriguing relationship. Alimentary Pharmacology & Therapeutics 24:9, pages 1295-1304.
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Laura Paajanen, Jorma Kokkonen, Tuomo J. Karttunen, Tuula Tuure, Riitta Korpela & Outi Vaarala. (2006) Intestinal Cytokine mRNA Expression in Delayed‐type Cow's Milk Allergy. Journal of Pediatric Gastroenterology and Nutrition 43:4, pages 470-476.
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Laura Paajanen, Riitta Korpela, Tuula Tuure, Jarno Honkanen, Irma Järvelä, Jorma Ilonen, Mikael Knip, Outi Vaarala & Jorma Kokkonen. (2005) Cow milk is not responsible for most gastrointestinal immune-like syndromes—evidence from a population-based study. The American Journal of Clinical Nutrition 82:6, pages 1327-1335.
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Hiroshi Akiyama, Yuji Sato, Takahiro Watanabe, Megumi H. Nagaoka, Yasuo Yoshioka, Toshihiko Shoji, Tomomasa Kanda, Kiyoshi Yamada, Mamoru Totsuka, Reiko Teshima, Jun-ichi Sawada, Yukihiro Goda & Tamio Maitani. (2005) Dietary unripe apple polyphenol inhibits the development of food allergies in murine models. FEBS Letters 579:20, pages 4485-4491.
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Laura Paajanen, Outi Vaarala, Riitta Karttunen, Tuula Tuure, Riitta Korpela & Jorma Kokkonen. (2005) Increased IFN‐ γ secretion from duodenal biopsy samples in delayed‐type cow's milk allergy . Pediatric Allergy and Immunology 16:5, pages 439-444.
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Andrew J. Wakefield, Paul Ashwood, Kirsten Limb & Andrew Anthony. (2005) The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. European Journal of Gastroenterology & Hepatology 17:8, pages 827-836.
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Mila Haapalahti, Petri Kulmala, Tuomo J Karttunen, Laura Paajanen, Kaija Laurila, Markku Mäki, Hannu Mykkänen & Jorma Kokkonen. (2005) Nutritional Status in Adolescents and Young Adults with Screen‐Detected Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition 40:5, pages 566-570.
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Merja T Augustin, Jorma Kokkonen & Tuomo J Karttunen. (2005) Evidence for Increased Apoptosis of Duodenal Intraepithelial Lymphocytes in Cow's Milk Sensitive Enteropathy. Journal of Pediatric Gastroenterology and Nutrition 40:3, pages 352-358.
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Haruyo Okunuki, Reiko Teshima, Yuji Sato, Ryosuke Nakamura, Hiroshi Akiyama, Tamio Maitani & Jun-ichi Sawada. (2005) The Hyperresponsiveness of W/Wv Mice to Oral Sensitization Is Associated with a Decrease in TCR.GAMMA..DELTA.-T Cells. Biological and Pharmaceutical Bulletin 28:4, pages 584-590.
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J Kokkonen, K Holm, TJ Karttunen & M Mäki. (2007) Enhanced local immune response in children with prolonged gastrointestinal symptoms. Acta Paediatrica 93:12, pages 1601-1607.
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Sami Turunen, Tuomo J. Karttunen & Jorma Kokkonen. (2004) Lymphoid nodular hyperplasia and cow's milk hypersensitivity in children with chronic constipation. The Journal of Pediatrics 145:5, pages 606-611.
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J Kokkonen, M Haapalahti, S Tikkanen, R Karttunen & E Savilahti. (2007) Gastrointestinal complaints and diagnosis in children: a population‐based study. Acta Paediatrica 93:7, pages 880-886.
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Jorma Kokkonen & Aila Niinimäki. (2004) Increased incidence of autoimmune disorders as a late complication in children with early onset dermatitis and/or milk allergy. Journal of Autoimmunity 22:4, pages 341-344.
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Gabor Veres, Mia Westerholm-Ormio, Jorma Kokkonen, Andras Arato & Erkki Savilahti. (2003) Cytokines and Adhesion Molecules in Duodenal Mucosa of Children with Delayed-Type Food Allergy. Journal of Pediatric Gastroenterology and Nutrition 37:1, pages 27-34.
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Gabor Veres, Mia Westerholm‐Ormio, Jorma Kokkonen, Andras Arato & Erkki Savilahti. (2003) Cytokines and Adhesion Molecules in Duodenal Mucosa of Children with Delayed‐Type Food Allergy. Journal of Pediatric Gastroenterology and Nutrition 37:1, pages 27-34.
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Haruyo Okunuki, Reiko Teshima, Naoki Harikai, Shinobu Sakai, Hiroshi Akiyama, Tamio Maitani & Jun-ichi Sawada. (2003) Oral Sensitization of W/Wv Mice with Ovalbumin and Possible Involvement of the Decrease in .GAMMA..DELTA.-T Cells. Biological and Pharmaceutical Bulletin 26:9, pages 1260-1265.
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Jani Rytkönen, Tuomo J. Karttunen, Riitta Karttunen, Kaija H. Valkonen, Maria C. Jenmalm, Tapani Alatossava, Bengt Björkstén & Jorma Kokkonen. (2002) Effect of heat denaturation on beta-lactoglobulin-induced gastrointestinal sensitization in rats: Denatured βLG induces a more intensive local immunologic response than native βLG. Pediatric Allergy and Immunology 13:4, pages 269-277.
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Jorma Kokkonen, Sami Tikkanen, Tuomo J. Karttunen & Erkki Savilahti. (2002) A similar high level of immunoglobulin A and immunoglobulin G class milk antibodies and increment of local lymphoid tissue on the duodenal mucosa in subjects with cow's milk allergy and recurrent abdominal pains. Pediatric Allergy and Immunology 13:2, pages 129-136.
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Jorma Kokkonen, Tarja Ruuska, Tuomo J Karttunen & Markku Mäki. (2002) Lymphonodular Hyperplasia of The Terminal Ileum Associated With Colitis Shows An Increased γδ+ T-Cell Density in Children. American Journal of Gastroenterology 97:3, pages 667-672.
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Jorma Kokkonen & Tuomo J. Karttunen. (2002) Lymphonodular Hyperplasia on the Mucosa of the Lower Gastrointestinal Tract in Children: An Indication of Enhanced Immune Response?. Journal of Pediatric Gastroenterology and Nutrition 34:1, pages 42-46.
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Jorma Kokkonen & Tuomo J. Karttunen. (2002) Lymphonodular Hyperplasia on the Mucosa of the Lower Gastrointestinal Tract in Children: An Indication of Enhanced Immune Response?. Journal of Pediatric Gastroenterology and Nutrition 34:1, pages 42-46.
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