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Scandinavian Journal of Gastroenterology Volume 35, 2000 - Issue 11
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Research Article

Abnormal Intestinal Permeability Predicts Relapse in Inactive Crohn Disease

I. D. R. Arnott, K. Kingstone, S. Ghosh Gastrointestinal Unit, University Department of Medicine, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU Scotland, UK
Pages 1163-1169 | Published online: 08 Jul 2009

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Yaxian Li, Mengdi Ma, Xiaodong Wang, Jing Li, Ziqing Fang, Jianhui Li, Bo Yang, Yida Lu, Xin Xu & Yongxiang Li. (2024) Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis. Immunopharmacology and Immunotoxicology 46:2, pages 240-254.
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Yongguo Zhang, Shaoping Wu, Jun Ma, Yinglin Xia, Xun Ai & Jun Sun. (2015) Bacterial protein AvrA stabilizes intestinal epithelial tight junctions via blockage of the C-Jun N-terminal kinase pathway. Tissue Barriers 3:1-2.
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Christoph Cichon, Harshana Sabharwal, Christian Rüter & M Alexander Schmidt. (2014) MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions. Tissue Barriers 2:4.
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Vladimir Stanisic & Eamonn MM Quigley. (2014) The overlap between IBS and IBD – what is it and what does it mean?. Expert Review of Gastroenterology & Hepatology 8:2, pages 139-145.
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Yong-guo Zhang, Shaoping Wu & Jun Sun. (2013) Vitamin D, vitamin D receptor and tissue barriers. Tissue Barriers 1:1.
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Aleixo Muise & Daniela Rotin. (2008) Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene. Expert Review of Molecular Diagnostics 8:4, pages 465-477.
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Lars Olbe. (2008) Concept of Crohn's disease being conditioned by four main components, and irritable bowel syndrome being an incomplete Crohn's disease. Scandinavian Journal of Gastroenterology 43:2, pages 234-241.
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Signe Wildt, Jan L. Madsen & Jüri J. Rumessen. (2006) Small-bowel permeability in collagenous colitis. Scandinavian Journal of Gastroenterology 41:9, pages 1044-1049.
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Andreas Muehler, Jason R Slizgi, Hella Kohlhof, Manfred Groeppel, Evelyn Peelen & Daniel Vitt. (2020) Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases. World Journal of Gastrointestinal Pathophysiology 11:6, pages 114-130.
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Carolynn M. Dude, Anissa Saylany, Amy Brown, Michal Elovitz & Lauren Anton. (2020) Microbial supernatants from Mobiluncus mulieris, a bacteria strongly associated with spontaneous preterm birth, disrupts the cervical epithelial barrier through inflammatory and miRNA mediated mechanisms. Anaerobe 61, pages 102127.
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Ying Yang, Lulu Zhang, Guoyong Jiang, Aitong Lei, Qiang Yu, Jianhua Xie & Yi Chen. (2019) Evaluation of the protective effects of Ganoderma atrum polysaccharide on acrylamide-induced injury in small intestine tissue of rats . Food & Function 10:9, pages 5863-5872.
Crossref
Doug N. Halligan, Mohammed N. Khan, Eric Brown, Catherine R. Rowan, Ivan S. Coulter, Glen A. Doherty, Murtaza M. Tambuwala & Cormac T. Taylor. (2019) Hypoxia-inducible factor hydroxylase inhibition enhances the protective effects of cyclosporine in colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 317:2, pages G90-G97.
Crossref
Yalan Huang, Yu Wang, Yanhai Feng, Pei Wang, Xiaochong He, Hui Ren & Fengjun Wang. (2019) Role of Endoplasmic Reticulum Stress-Autophagy Axis in Severe Burn-Induced Intestinal Tight Junction Barrier Dysfunction in Mice. Frontiers in Physiology 10.
Crossref
Yanlong Li, Xudong Tian, Shengcai Li, Lijun Chang, Ping Sun, Yubei Lu, Xiaoyan Yu, Shiwang Chen, Zhengquan Wu, Zhong Xu & Wanrong Kang. (2019) Total polysaccharides of adlay bran ( Coix lachryma-jobi L.) improve TNF-α induced epithelial barrier dysfunction in Caco-2 cells via inhibition of the inflammatory response . Food & Function 10:5, pages 2906-2913.
Crossref
Prianka Gajula & Eamonn M. Quigley. (2019) Overlapping irritable bowel syndrome and inflammatory bowel disease. Minerva Gastroenterologica e Dietologica 65:2.
Crossref
Kathryn Burge, Aarthi Gunasekaran, Jeffrey Eckert & Hala Chaaban. (2019) Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. International Journal of Molecular Sciences 20:8, pages 1912.
Crossref
Maria Stefania Lepanto, Luigi Rosa, Rosalba Paesano, Piera Valenti & Antimo Cutone. (2019) Lactoferrin in Aseptic and Septic Inflammation. Molecules 24:7, pages 1323.
Crossref
Pan Xu, Elhaseen Elamin, Montserrat Elizalde, Paul P. H. A. Bours, Marieke J. Pierik, Ad A. M. Masclee & Daisy M. A. E. Jonkers. (2019) Modulation of Intestinal Epithelial Permeability by Plasma from Patients with Crohn’s Disease in a Three-dimensional Cell Culture Model. Scientific Reports 9:1.
Crossref
Julius Z. H. von Martels, Arno R. Bourgonje, Hermie J. M. Harmsen, Klaas Nico Faber & Gerard Dijkstra. (2019) Assessing intestinal permeability in Crohn’s disease patients using orally administered 52Cr-EDTA. PLOS ONE 14:2, pages e0211973.
Crossref
Xiao Zhao, Xiao-Xi Xu, Yang Liu, En-Ze Xi, Jing-Jing An, Dina Tabys & Ning Liu. (2019) The In Vitro Protective Role of Bovine Lactoferrin on Intestinal Epithelial Barrier. Molecules 24:1, pages 148.
Crossref
Lin Zhang, Feng Zhang, Dai‐Kun He, Xiao‐Ming Fan & Jie Shen. (2018) MicroRNA‐21 is upregulated during intestinal barrier dysfunction induced by ischemia reperfusion. The Kaohsiung Journal of Medical Sciences 34:10, pages 556-563.
Crossref
Jonathan E. Wosen, Dhriti Mukhopadhyay, Claudia Macaubas & Elizabeth D. Mellins. (2018) Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts. Frontiers in Immunology 9.
Crossref
Josie Libertucci, Usha Dutta, Sandeep Kaur, Jennifer Jury, Laura Rossi, Michelle E. Fontes, M. Sharif Shajib, Waliul I. Khan, Michael G. Surette, Elena F. Verdu & David Armstrong. (2018) Inflammation-related differences in mucosa-associated microbiota and intestinal barrier function in colonic Crohn’s disease. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:3, pages G420-G431.
Crossref
Chaithanya Chelakkot, Jaewang Ghim & Sung Ho Ryu. (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Experimental & Molecular Medicine 50:8, pages 1-9.
Crossref
Yue Lu, Leng Li, Jin-Wei Zhang, Xiao-Qin Zhong, Jian-An Wei & Ling Han. (2018) Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway . World Journal of Gastroenterology 24:26, pages 2867-2877.
Crossref
Camille Pochard, Sabrina Coquenlorge, Marie Freyssinet, Philippe Naveilhan, Arnaud Bourreille, Michel Neunlist & Malvyne Rolli-Derkinderen. (2018) The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy?. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:1, pages G1-G11.
Crossref
Kanae Gamo, Yuumi Okuzono, Masato Yabuki, Takashi Ochi, Kyoko Sugimura, Yosuke Sato, Masaki Sagara, Hiroki Hayashi, Yoshimasa Ishimura, Yutaka Nishimoto, Yusuke Murakawa, Zenyu Shiokawa, Masayuki Gotoh, Takahiro Miyazaki & Yukihiko Ebisuno. (2018) Gene Signature–Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn’s Disease. Inflammatory Bowel Diseases 24:6, pages 1251-1265.
Crossref
Fredrik E.O. Holmberg, Jannie Pedersen, Peter Jørgensen, Christoffer Soendergaard, Kim B. Jensen & Ole H. Nielsen. (2017) Intestinal barrier integrity and inflammatory bowel disease: Stem cell‐based approaches to regenerate the barrier. Journal of Tissue Engineering and Regenerative Medicine 12:4, pages 923-935.
Crossref
Jessica Lee, Valerie Wasinger, Yunki Yau, Emil Chuang, Vijay Yajnik & Rupert Leong. (2018) Molecular Pathophysiology of Epithelial Barrier Dysfunction in Inflammatory Bowel Diseases. Proteomes 6:2, pages 17.
Crossref
Jun Deng, Lishan Zeng, Xueying Lai, Jing Li, Le Liu, Qianyun Lin & Ye Chen. (2017) Metformin protects against intestinal barrier dysfunction via AMPKα1‐dependent inhibition of JNK signalling activation . Journal of Cellular and Molecular Medicine 22:1, pages 546-557.
Crossref
Nour Eissa, Hayam Hussein, Laëtitia Kermarrec, Jasmine Grover, Marie-Hélène Et Metz-Boutigue, Charles N. Bernstein & Jean-Eric Ghia. (2017) Chromofungin Ameliorates the Progression of Colitis by Regulating Alternatively Activated Macrophages. Frontiers in Immunology 8.
Crossref
Nitesh Shashikanth, Sunil Yeruva, Ma. Lora Drizella M. Ong, Matthew A. Odenwald, Roman Pavlyuk & Jerrold R. Turner. 2011. Comprehensive Physiology. Comprehensive Physiology 1497 1518 .
J.R. BaileyV. VinceN.A. WilliamsT.A. Cogan. (2017) Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease. Beneficial Microbes 8:4, pages 605-614.
Crossref
Prashant K. Nighot, Lana Leung & Thomas Y. Ma. (2017) Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Experimental Cell Research 352:1, pages 113-122.
Crossref
Matthew A. Odenwald & Jerrold R. Turner. (2016) The intestinal epithelial barrier: a therapeutic target?. Nature Reviews Gastroenterology & Hepatology 14:1, pages 9-21.
Crossref
M.L. Smythe. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 157 170 .
Eamonn M. M. Quigley. (2015) Overlapping irritable bowel syndrome and inflammatory bowel disease: less to this than meets the eye?. Therapeutic Advances in Gastroenterology 9:2, pages 199-212.
Crossref
Carlos Teruel. (2016) Diagnosis and management of functional symptoms in inflammatory bowel disease in remission. World Journal of Gastrointestinal Pharmacology and Therapeutics 7:1, pages 78.
Crossref
Elisa Liverani. (2016) How to predict clinical relapse in inflammatory bowel disease patients. World Journal of Gastroenterology 22:3, pages 1017.
Crossref
Prashant NighotRana Al-SadiManmeet RawatShuhong GuoD. Martin Watterson & Thomas Ma. (2015) Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 309:12, pages G988-G997.
Crossref
Ibrahim K. Onal, Yavuz Beyazit, Akif Altinbas, Mevlut Kurt & Mehmet Arhan. (2015) Maintenance therapy for Crohn’s disease. European Journal of Gastroenterology & Hepatology 27:10, pages 1115-1125.
Crossref
Derek Chan, Devinder Kumar & Mike Mendall. (2015) What is known about the mechanisms of dietary influences in Crohn's disease?. Nutrition 31:10, pages 1195-1203.
Crossref
Nitsan Maharshak, Eun Young Huh, Chorlada Paiboonrungruang, Michael Shanahan, Lance Thurlow, Jeremy Herzog, Zorka Djukic, Roy Orlando, Rafal Pawlinski, Melissa Ellermann, Luke Borst, Siten Patel, Iris Dotan, Ryan B. Sartor & Ian M. Carroll. (2015) Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2. Infection and Immunity 83:7, pages 2762-2770.
Crossref
Shameer Mehta, Anke Nijhuis, Tomoko Kumagai, James Lindsay & Andrew Silver. (2014) Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease. Cell and Tissue Research 360:3, pages 749-760.
Crossref
Lin Zhang, Jie Shen, Jian Cheng & Xiaoming Fan. (2015) MicroRNA‐21 regulates intestinal epithelial tight junction permeability. Cell Biochemistry and Function 33:4, pages 235-240.
Crossref
S. Dhawan, I. H. Hiemstra, C. Verseijden, F. W. Hilbers, A. A. te Velde, L. E. M. Willemsen, J. Stap, J. M. den Haan & W. J. de Jonge. (2015) Cholinergic receptor activation on epithelia protects against cytokine‐induced barrier dysfunction. Acta Physiologica 213:4, pages 846-859.
Crossref
V. Morampudi, V. S. Conlin, U. Dalwadi, X. Wu, K. C. Marshall, C. Nguyen, B. A. Vallance & K. Jacobson. (2015) Vasoactive intestinal peptide prevents PKCε-induced intestinal epithelial barrier disruption during EPEC infection. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:5, pages G389-G402.
Crossref
Prashant K. Nighot, Chien-An Andy Hu & Thomas Y. Ma. (2015) Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation. Journal of Biological Chemistry 290:11, pages 7234-7246.
Crossref
Amit Assa, Linda Vong, Lee J. Pinnell, Jaana Rautava, Naama Avitzur, Kathene C. Johnson-Henry & Philip M. Sherman. (2015) Vitamin D Deficiency Predisposes to Adherent-invasive Escherichia coli-induced Barrier Dysfunction and Experimental Colonic Injury. Inflammatory Bowel Diseases 21:2, pages 297-306.
Crossref
Declan F. McCole. (2014) IBD Candidate Genes and Intestinal Barrier Regulation. Inflammatory Bowel Diseases 20:10, pages 1829-1849.
Crossref
Fernando Ochoa-Cortes, Andromeda Liñán-Rico, Kenneth A. Jacobson & Fievos L. Christofi. (2014) Potential for Developing Purinergic Drugs for Gastrointestinal Diseases. Inflammatory Bowel Diseases 20:7, pages 1259-1287.
Crossref
M Vivinus-Nébot, G Frin-Mathy, H Bzioueche, R Dainese, G Bernard, R Anty, J Filippi, M C Saint-Paul, M K Tulic, V Verhasselt, X Hébuterne & T Piche. (2014) Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation. Gut 63:5, pages 744-752.
Crossref
Prashant Nighot, Karen Young, Meghali Nighot, Manmeet Rawat, Eui J. Sung, Nitsan Maharshak, Scott E. Plevy, Thomas Ma & Anthony Blikslager. (2013) Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis. Inflammatory Bowel Diseases 19:13, pages 2867-2877.
Crossref
C. O. Musumba. (2013) Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy. Alimentary Pharmacology & Therapeutics 38:9, pages 1025-1037.
Crossref
Kelly R. Bergmann, Shirley X.L. Liu, Runlan Tian, Anna Kushnir, Jerrold R. Turner, Hong-Lin Li, Pauline M. Chou, Christopher R. Weber & Isabelle G. De Plaen. (2013) Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis. The American Journal of Pathology 182:5, pages 1595-1606.
Crossref
Yong-guo Zhang, Shaoping Wu, Yinglin Xia & Jun Sun. (2013) Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells. PLoS ONE 8:3, pages e58606.
Crossref
Michel Neunlist, Laurianne Van Landeghem, Maxime M. Mahé, Pascal Derkinderen, Stanislas Bruley des Varannes & Malvyne Rolli-Derkinderen. (2012) The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease. Nature Reviews Gastroenterology & Hepatology 10:2, pages 90-100.
Crossref
Xiaochang Liu, Jianming Xu, Qiao Mei, Liang Han & Jian Huang. (2012) Myosin Light Chain Kinase Inhibitor Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice. Digestive Diseases and Sciences 58:1, pages 107-114.
Crossref
Franco Scaldaferri, Marco Pizzoferrato, Viviana Gerardi, Loris Lopetuso & Antonio Gasbarrini. (2012) The Gut Barrier. Journal of Clinical Gastroenterology 46, pages S12-S17.
Crossref
Jane M.M. Natividad, Valerie Petit, Xianxi Huang, Giada de Palma, Jennifer Jury, Yolanda Sanz, Dana Philpott, Clara L. Garcia Rodenas, Kathy D. McCoy & Elena F. Verdu. (2012) Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− Mice. Inflammatory Bowel Diseases 18:8, pages 1434-1446.
Crossref
Rainer Noth, Eckhard Stüber, Robert Häsler, Susanna Nikolaus, Tanja Kühbacher, Jochen Hampe, Burkhard Bewig, Stefan Schreiber & Alexander Arlt. (2012) Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease. Journal of Crohn's and Colitis 6:4, pages 464-469.
Crossref
Jeremy Denizot, Adeline Sivignon, Frederick Barreau, Claude Darcha, Carlos H.F. Chan, Clifford P. Stanners, Paul Hofman, Arlette Darfeuille-Michaud & Nicolas Barnich. (2012) Adherent-Invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohnʼs Disease Patients§. Inflammatory Bowel Diseases 18:2, pages 294-304.
Crossref
Dongmei Ye, Shuhong Guo, Rana Al–Sadi & Thomas Y. Ma. (2011) MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability. Gastroenterology 141:4, pages 1323-1333.
Crossref
Vanya A Gerova, Simeon G Stoynov, Dimitar S Katsarov & Dobrin A Svinarov. (2011) Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test. World Journal of Gastroenterology 17:17, pages 2211-2215.
Crossref
Mirjam Looijer-van Langen, Naomi Hotte, Levinus A. Dieleman, Eric Albert, Chris Mulder & Karen L. Madsen. (2011) Estrogen receptor-β signaling modulates epithelial barrier function. American Journal of Physiology-Gastrointestinal and Liver Physiology 300:4, pages G621-G626.
Crossref
Alexandra I. Thompson & Charlie W. Lees. (2011) Genetics of ulcerative colitis. Inflammatory Bowel Diseases 17:3, pages 831-848.
Crossref
Sonia S. Yoon & Jun Sun. (2011) Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways. Gastroenterology Research and Practice 2011, pages 1-16.
Crossref
Saʼad Y. Salim & Johan D. Söderholm. (2011) Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflammatory Bowel Diseases 17:1, pages 362-381.
Crossref
Marloes A. A. Schepens, Anneke Rijnierse, Arjan J. Schonewille, Carolien Vink, Robert-Jan M. Brummer, Linette E. M. Willemsen, Roelof van der Meer & Ingeborg M. J. Bovee-Oudenhoven. (2010) Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats. British Journal of Nutrition 104:12, pages 1780-1786.
Crossref
Sheila M. Innis, Chuanbin Dai, Xiujuan Wu, Alison M. J. Buchan & Kevan Jacobson. (2010) Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 299:6, pages G1376-G1385.
Crossref
Jung Mogg Kim. (2010) Inflammatory Bowel Diseases and Enteric Microbiota. The Korean Journal of Gastroenterology 55:1, pages 4.
Crossref
Marloes A.A. Schepens, Arjan J. Schonewille, Carolien Vink, Evert M. van Schothorst, Evelien Kramer, Thijs Hendriks, Robert-Jan Brummer, Jaap Keijer, Roelof van der Meer & Ingeborg M.J. Bovee-Oudenhoven. (2009) Supplemental Calcium Attenuates the Colitis-Related Increase in Diarrhea, Intestinal Permeability, and Extracellular Matrix Breakdown in HLA-B27 Transgenic Rats. The Journal of Nutrition 139:8, pages 1525-1533.
Crossref
Brian K. Reuter & Theresa T. Pizarro. (2009) Mechanisms of Tight Junction Dysregulation in the SAMP1/YitFc Model of Crohn's Disease–like Ileitis. Annals of the New York Academy of Sciences 1165:1, pages 301-307.
Crossref
V. Haas, C. Büning, S. Buhner, C. Von Heymann, L. Valentini & H. Lochs. (2009) Clinical relevance of measuring colonic permeability. European Journal of Clinical Investigation 39:2, pages 139-144.
Crossref
Julia B. Ewaschuk, Hugo Diaz, Liisa Meddings, Brendan Diederichs, Andrea Dmytrash, Jody Backer, Mirjam Looijer-van Langen & Karen L. Madsen. (2008) Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function . American Journal of Physiology-Gastrointestinal and Liver Physiology 295:5, pages G1025-G1034.
Crossref
H. Vogelsang. (2008) Do changes in intestinal permeability predict disease relapse in Crohnʼs disease?. Inflammatory Bowel Diseases 14:Supplement, pages S162-S163.
Crossref
H. Vogelsang. (2008) Do changes in intestinal permeability predict disease relapse in Crohnʼs disease?. Inflammatory Bowel Diseases 14, pages S162-S163.
Crossref
Alper Akcan. (2008) Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats. World Journal of Gastroenterology 14:06, pages 918.
Crossref
Jaya Benjamin, Govind K Makharia, Vineet Ahuja, Mani Kalaivani & Yogendra K Joshi. (2008) Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease. World Journal of Gastroenterology 14:9, pages 1399.
Crossref
Qiurong Li, Qiang Zhang, Meng Wang, Sumin Zhao, Jian Ma, Nan Luo, Ning Li, Yousheng Li, Guowang Xu & Jieshou Li. (2008) Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction. Clinical Immunology 126:1, pages 67-80.
Crossref
A. Loganayagam & I. Bjarnason. 2008. IBD 2007 — Achievements in Research and Clinical Practice. IBD 2007 — Achievements in Research and Clinical Practice 129 142 .
Nita H. Salzman & Charles L. Bevins. 2008. GI Microbiota and Regulation of the Immune System. GI Microbiota and Regulation of the Immune System 67 78 .
BL Kelsall. (2007) Innate and adaptive mechanisms to control of pathological intestinal inflammation. The Journal of Pathology 214:2, pages 242-259.
Crossref
Martijn JL Bours, Hilde J Bos, Jon B Meddings, Robert-Jan M Brummer, Piet A van den Brandt & Pieter C Dagnelie. (2007) Effects of oral adenosine 5'-triphosphate and adenosine in enteric-coated capsules on indomethacin-induced permeability changes in the human small intestine: a randomized cross-over study. BMC Gastroenterology 7:1.
Crossref
Emanuela Mazzon & Salvatore Cuzzocrea. (2007) ABSENCE OF FUNCTIONAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α ENHANCED ILEUM PERMEABILITY DURING EXPERIMENTAL COLITIS. Shock 28:2, pages 192-201.
Crossref
Martijn J. Bours, Freddy J. Troost, Robert-Jan M. Brummer, Aalt Bast & Pieter C. Dagnelie. (2007) Local effect of adenosine 5???-triphosphate on indomethacin-induced permeability changes in the human small intestine. European Journal of Gastroenterology & Hepatology 19:3, pages 245-250.
Crossref
Michel A. Boivin, Dongmei Ye, John C. Kennedy, Rana Al-Sadi, Chris Shepela & Thomas Y. Ma. (2007) Mechanism of glucocorticoid regulation of the intestinal tight junction barrier. American Journal of Physiology-Gastrointestinal and Liver Physiology 292:2, pages G590-G598.
Crossref
Fengjun Wang, Brad T. Schwarz, W. Vallen Graham, Yingmin Wang, Liping Su, Daniel R. Clayburgh, Clara Abraham & Jerrold R. Turner. (2006) IFN-γ-Induced TNFR2 Expression Is Required for TNF-Dependent Intestinal Epithelial Barrier Dysfunction. Gastroenterology 131:4, pages 1153-1163.
Crossref
Walter Fries, Maria C. Renda, Maria A. Lo Presti, Antonella Raso, Ambrogio Orlando, Lorenzo Oliva, Maria R. Giofre, Aurelio Maggio, Anna Mattaliano, Alfredo Macaluso & Mario Cottone. (2005) Intestinal Permeability and Genetic Determinants in Patients, First-Degree Relatives, and Controls in a High-Incidence Area of Crohn's Disease in Southern Italy. The American Journal of Gastroenterology 100:12, pages 2730-2736.
Crossref
Hideki Suzuki, Nozomi Hanyou, Ichiro Sonaka & Hisanori Minami. (2005) An Elemental Diet Controls Inflammation in Indomethacin-Induced Small Bowel Disease in Rats: The Role of Low Dietary Fat and the Elimination of Dietary Proteins. Digestive Diseases and Sciences 50:10, pages 1951-1958.
Crossref
Shyam Prasad, Roberto Mingrino, Katri Kaukinen, Katherine L Hayes, Robert M Powell, Thomas T MacDonald & Jane E Collins. (2005) Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Laboratory Investigation 85:9, pages 1139-1162.
Crossref
I. Bjarnason, L. Maiden & K. Takeuchi. 2005. Gastroenterology Yesterday — Today — Tomorrow: A Review and Preview. Gastroenterology Yesterday — Today — Tomorrow: A Review and Preview 253 266 .
S. Loret, G. Nollevaux, R. Remacle, M. Klimek, I. Barakat, P. Deloyer, C. Grandfils & G. Dandrifosse. (2004) Analysis of PEG 400 and 4000 in urine for gut permeability assessment using solid phase extraction and gel permeation chromatography with refractometric detection. Journal of Chromatography B 805:2, pages 195-202.
Crossref
Daniel R Clayburgh, Le Shen & Jerrold R Turner. (2004) A porous defense: the leaky epithelial barrier in intestinal disease. Laboratory Investigation 84:3, pages 282-291.
Crossref
G. E. Wild, K. A. Waschke, A. Bitton & A. B. R. Thomson. (2003) The mechanisms of prednisone inhibition of inflammation in Crohn's disease involve changes in intestinal permeability, mucosal TNFα production and nuclear factor kappa B expression. Alimentary Pharmacology & Therapeutics 18:3, pages 309-317.
Crossref
Yevgeny Zolotarevsky, Gail Hecht, Athanasia Koutsouris, Deborah E. Gonzalez, Cliff Quan, Jeffrey Tom, Randall J. Mrsny & Jerrold R. Turner. (2002) A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123:1, pages 163-172.
Crossref
I.D.R. Arnott, N. Williams, H.E. Drummond & S. Ghosh. (2002) Whole gut lavage fluid interleukin-1β and interleukin-8 in smokers and non-smokers with Crohn's disease in clinical remission. Digestive and Liver Disease 34:6, pages 424-429.
Crossref
I. D. R. Arnott, D. Watts & S. Ghosh. (2002) Is clinical remission the optimum therapeutic goal in the treatment of Crohn's disease?. Alimentary Pharmacology & Therapeutics 16:5, pages 857-867.
Crossref
I. Bjarnason, A. Cederborg, A. åkvist & S. Smale. 2002. Biology of the Intestine in Growing Animals. Biology of the Intestine in Growing Animals 657 693 .

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