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Research Article

Long-term Omeprazole Treatment Suppresses Body Weight Gain and Bone Mineralization in Young Male Rats

Pages 1011-1015 | Published online: 08 Jul 2009

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Karin Bakkelund, Reidar Fossmark, Ivar S. Nordrum & Helge L. Waldum. (2009) Effect of antrectomy in hypergastrinaemic female Japanese cotton rats. Scandinavian Journal of Gastroenterology 44:1, pages 32-39.
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Kathryn E. Gropp & Aurore Varela. 2024. Haschek and Rousseaux' s Handbook of Toxicologic Pathology. Haschek and Rousseaux' s Handbook of Toxicologic Pathology 249 360 .
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Gemma Di Pompo, Katsuyuki Kusuzaki, Marco Ponzetti, Vito Ferdinando Leone, Nicola Baldini & Sofia Avnet. (2022) Radiodynamic Therapy with Acridine Orange Is an Effective Treatment for Bone Metastases. Biomedicines 10:8, pages 1904.
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Reina Yoshioka, Yuichi Mine, Masato Kaku, Hiroki Nikawa & Takeshi Murayama. (2022) Lansoprazole and zoledronate delays hard tissue healing of tooth extraction sockets in dexamethasone-treated mice. Biomedicine & Pharmacotherapy 150, pages 112991.
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Morten Steen Hansen & Morten Frost. (2022) Alliances of the gut and bone axis. Seminars in Cell & Developmental Biology 123, pages 74-81.
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Deepa B. Rao, Alan M. Hoberman, Paul C. Brown, Aurore Varela & Brad Bolon. (2021) Regulatory Perspectives on Juvenile Animal Toxicologic Pathology. Toxicologic Pathology 49:8, pages 1393-1404.
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Katherine A. Staines, Katherine Myers, Kirsty Little, Stuart H. Ralston & Colin Farquharson. (2021) Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro. Calcified Tissue International 109:6, pages 696-705.
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Kristin M. Aasarød, Mats P. Mosti, Malin T. Finstad, Astrid K. Stunes, Reidar Fossmark & Unni Syversen. (2021) Do patients with gastroesophageal reflux disease exhibit compromised bone quality prior to proton pump inhibitor therapy?. Bone Reports 14, pages 101095.
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Joe D. Pagan, Laura Petroski-Rose, Alana Mann & Ashlee Hauss. (2020) Omeprazole Reduces Calcium Digestibility in Thoroughbred Horses. Journal of Equine Veterinary Science 86, pages 102851.
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M. Hoff, E. Skovlund, S. Skurtveit, H.E. Meyer, A. Langhammer, A.J. Søgaard, U. Syversen, S. Forsmo, B. Abrahamsen & B. Schei. (2019) Proton pump inhibitors and fracture risk. The HUNT study, Norway. Osteoporosis International 31:1, pages 109-118.
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Reidar Fossmark, Tom C. Martinsen & Helge L. Waldum. (2019) Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility. International Journal of Molecular Sciences 20:20, pages 5203.
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Stacey L. Fossey, D. Greg Hall, Andrew W. Suttie, Martin Guillot & Aurore Varela. 2019. Toxicologic Pathology for Non-Pathologists. Toxicologic Pathology for Non-Pathologists 571 618 .
Scott C. Wagner. (2018) Proton Pump Inhibitors and Bone Health. JBJS Reviews 6:12, pages e6-e6.
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Olena Tsyryuk & Tetyana Beregova. (2018) Чутливість парієтальних клітин до стимуляторів шлункової секреції після тривалого введення омепразолу. Lesya Ukrainka Eastern European National University Scientific Bulletin. Series: Biological Sciences:2(302), pages 228-233.
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Aurore Varela & Jacquelin Jolette. (2018) Bone Toolbox: Biomarkers, Imaging Tools, Biomechanics, and Histomorphometry. Toxicologic Pathology 46:5, pages 511-529.
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Milena Saqui-Salces, Amy C. Tsao, Merritt G. GillillandIIIIII & Juanita L. Merchant. (2017) Weight gain in mice on a high caloric diet and chronically treated with omeprazole depends on sex and genetic background. American Journal of Physiology-Gastrointestinal and Liver Physiology 312:1, pages G15-G23.
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Aurore Varela. 2017. Bone Toxicology. Bone Toxicology 203 228 .
Thevaraajan Jayaraman, Muhammad Ilham Abdul Hafidz, Nazri Mustaffa & Yeong Yeh Lee. (2016) Should I Be Concerned with the Long-Term Use of Proton Pump Inhibitor Therapy?. EMJ Gastroenterology, pages 74-81.
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Agnieszka Matuszewska, Beata Nowak, Marta Rzeszutko, Krzysztof Zduniak, Marta Szandruk, Diana Jędrzejuk, Marcin Landwójtowicz, Marek Bolanowski, Małgorzata Pieśniewska, Joanna Kwiatkowska & Adam Szeląg. (2016) Effects of long-term administration of pantoprazole on bone mineral density in young male rats. Pharmacological Reports 68:5, pages 1060-1064.
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Kristin M Aasarød, Masoud Ramezanzadehkoldeh, Maziar Shabestari, Mats P Mosti, Astrid K Stunes, Janne E Reseland, Vidar Beisvag, Erik Fink Eriksen, Arne K Sandvik, Reinhold G Erben, Christiane Schüler, Malcolm Boyce, Bjørn H Skallerud, Unni Syversen & Reidar Fossmark. (2016) Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice. Journal of Endocrinology 230:2, pages 251-262.
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Stephanie S. Caston, Douglas C. Fredericks, Kevin D. Kersh & Chong Wang. (2015) Short-Term Omeprazole Use Does Not Affect Serum Calcium Concentrations and Bone Density in Horses. Journal of Equine Veterinary Science 35:9, pages 714-723.
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Yu-Fong Syu, Hsien-Hao Huang & Chih-Yen Chen. (2015) Do Proton Pump Inhibitors Contribute to Weight Gain?. Obesity Surgery 25:6, pages 1071-1072.
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Gabriela Rezende Yanagihara, Aline Goulart de Paiva, Maurílio Pacheco Neto, Larissa Helena Torres, Antônio Carlos Shimano, Mário Jefferson Quirino Louzada, Raquel Annoni & Álvaro César de Oliveira Penoni. (2015) Effects of long-term administration of omeprazole on bone mineral density and the mechanical properties of the bone. Revista Brasileira de Ortopedia (English Edition) 50:2, pages 232-238.
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Gabriela Rezende Yanagihara, Aline Goulart de Paiva, Maurílio Pacheco Neto, Larissa Helena Torres, Antônio Carlos Shimano, Mário Jefferson Quirino Louzada, Raquel Annoni & Álvaro César de Oliveira Penoni. (2015) Efeitos da administração em longo prazo do omeprazol sobre a densidade mineral óssea e as propriedades mecânicas do osso. Revista Brasileira de Ortopedia 50:2, pages 232-238.
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Susannah O'Sullivan & Andrew Grey. (2014) Adverse skeletal effects of drugs – beyond Glucocorticoids. Clinical Endocrinology 82:1, pages 12-22.
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Patric J.D. Delhanty, Bram C.J. van der Eerden & Johannes P.T.M. van Leeuwen. (2013) Ghrelin and bone. BioFactors 40:1, pages 41-48.
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J. Keller & T. Schinke. (2013) The role of the gastrointestinal tract in calcium homeostasis and bone remodeling. Osteoporosis International 24:11, pages 2737-2748.
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Vishal Patel, Amit Joharapurkar, Tejal Gandhi, Kirti Patel, Nirav Dhanesha, Samadhan Kshirsagar, Vipin Dhote, Jaysukh Detroja, Rajesh Bahekar & Mukul Jain. (2013) Omeprazole improves the anti‐obesity and antidiabetic effects of exendin‐4 in db/db mice (奥美拉唑改善唾液素‐4 对 db/db 小鼠的减肥与降糖作用)* . Journal of Diabetes 5:2, pages 163-171.
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Piotr Dobrowolski, Ewa Tomaszewska, Radoslaw P. Radzki, Marek Bienko, Jerzy Wydrych, Adam Zdybel & Stefan G. Pierzynowski. (2013) Can 2-oxoglutarate prevent changes in bone evoked by omeprazole?. Nutrition 29:3, pages 556-561.
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Thorsten Schinke & Michael Amling. 2013. Translational Endocrinology of Bone. Translational Endocrinology of Bone 63 71 .
Yu-Xiao Yang. (2012) Chronic Proton Pump Inihibitor Therapy and Calcium Metabolism. Current Gastroenterology Reports 14:6, pages 473-479.
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Laura E Targownik, William D Leslie, Shawn K Davison, David Goltzman, Sophie A Jamal, Nancy Kreiger, Robert G Josse, Stephanie M Kaiser, Christopher S Kovacs, Jerilynn C Prior & Wei Zhou. (2012) The Relationship Between Proton Pump Inhibitor Use and Longitudinal Change in Bone Mineral Density: A Population-Based From the Canadian Multicentre Osteoporosis Study (CaMos). American Journal of Gastroenterology 107:9, pages 1361-1369.
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Maria Pytlik, Urszula Cegieła, Joanna Folwarczna & Barbara Nowińska. (2012) Proton pump (H+/K+-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats. Pharmacological Reports 64:3, pages 625-634.
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Reidar Fossmark, Astrid K. Stunes, Christiane Petzold, Helge L. Waldum, Marina Rubert, Aina‐Mari Lian, Janne E. Reseland & Unni Syversen. (2011) Decreased bone mineral density and reduced bone quality in H + /K + ATPase beta‐subunit deficient mice . Journal of Cellular Biochemistry 113:1, pages 141-147.
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James M. Mullin, Melissa Gabello, Lisa J. Murray, Christopher P. Farrell, Jillan Bellows, Kevin R. Wolov, Keith R. Kearney, David Rudolph & James J. Thornton. (2009) Proton pump inhibitors: actions and reactions. Drug Discovery Today 14:13-14, pages 647-660.
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Michael D Burkitt, Andrea Varro & D Mark Pritchard. (2009) Importance of gastrin in the pathogenesis and treatment of gastric tumors. World Journal of Gastroenterology 15:1, pages 1.
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David L. Carlton, Lissa J. Collin-Smith, Alejandro J. Daniels, David N. Deaton, Aaron S. Goetz, Christopher P. Laudeman, Thomas R. Littleton, David L. Musso, Ronda J. Ott Morgan, Jerzy R. Szewczyk & Cunyu Zhang. (2008) Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead. Bioorganic & Medicinal Chemistry Letters 18:20, pages 5451-5455.
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Elaine W. Yu, Terri Blackwell, Kristine E. Ensrud, Teresa A. Hillier, Nancy E. Lane, Eric Orwoll & Douglas C. Bauer. (2008) Acid-Suppressive Medications and Risk of Bone Loss and Fracture in Older Adults. Calcified Tissue International 83:4, pages 251-259.
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Iain A. Murray & Gary H. Perdew. (2008) Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon Receptor Activation. Journal of Pharmacology and Experimental Therapeutics 324:3, pages 1102-1110.
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Tatsuhiro Masaoka, Hidekazu Suzuki & Toshifumi Hibi. (2008) Gastric Epithelial Cell Modality and Proton Pump Inhibitor. Journal of Clinical Biochemistry and Nutrition 42:3, pages 191-196.
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Atsushi Tatsuguchi, Kazumasa Miyake, Katya Gudis, Seiji Futagami, Taku Tsukui, Ken Wada, Teruyuki Kishida, Yuh Fukuda, Yuichi Sugisaki & Choitsu Sakamoto. (2004) Effect of Helicobacter pylori Infection on Ghrelin Expression in Human Gastric Mucosa. The American Journal of Gastroenterology 99:11, pages 2121-2127.
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