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Research Article

Low Faecal Elastase 1 Concentrations in Type 2 Diabetes Mellitus

Pages 1056-1061 | Published online: 08 Jul 2009

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David C. Dallas, Megan R. Sanctuary, Yunyao Qu, Shabnam Haghighat Khajavi, Alexandria E. Van Zandt, Melissa Dyandra, Steven A. Frese, Daniela Barile & J. Bruce German. (2017) Personalizing protein nourishment. Critical Reviews in Food Science and Nutrition 57:15, pages 3313-3331.
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Dietrich Rothenbacher, Michael Löw, Philip D. Hardt, Hans-Ulrich Klör, Hartwig Ziegler & Hermann Brenner. (2005) Prevalence and determinants of exocrine pancreatic insufficiency among older adults: Results of a population-based study. Scandinavian Journal of Gastroenterology 40:6, pages 697-704.
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Articles from other publishers (63)

Roberto Valente, Alessandro Coppola, Chiara Maria Scandavini, Asif Halimi, Annelie Magnusson, Augusto Lauro, Ira Sotirova, Urban Arnelo & Oskar Franklin. (2024) Interactions between the Exocrine and the Endocrine Pancreas. Journal of Clinical Medicine 13:4, pages 1179.
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Sana Rafaqat, Ramsha Hafeez, Rida Mairaj, Abeerah Saleem & Saira Rafaqat. (2023) Pancreatic biomarkers: role in diabetes mellitus. Journal of Pancreatology 6:4, pages 169-177.
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Alok Mathew, Darren Fernandes & H Jervoise N Andreyev. (2023) What is the significance of a faecal elastase-1 level between 200 and 500μg/g?. Frontline Gastroenterology 14:5, pages 371-376.
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Dana M. Lewis. (2023) A Systematic Review of Exocrine Pancreatic Insufficiency Prevalence and Treatment in Type 1 and Type 2 Diabetes. Diabetes Technology & Therapeutics 25:9, pages 659-672.
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Susanne Kaser, Sabine E. Hofer, Lili Kazemi-Shirazi, Andreas Festa, Yvonne Winhofer, Harald Sourij, Helmut Brath, Michaela Riedl, Michael Resl, Martin Clodi, Thomas Stulnig, Claudia Ress & Anton Luger. (2023) Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2023)Other specific types of diabetes and exocrine pancreatic insufficiency (update 2023). Wiener klinische Wochenschrift 135:S1, pages 18-31.
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Marinus A. Kempeneers, Yama Issa, Usama Ahmed Ali, Marco J. Bruno, Erwin J. M. van Geenen, Jeanin E. van Hooft, Tessa E. H. Römkens, Peter D. Siersema, B. W. Marcel Spanier, Ibtisam Yahya, J. Hans DeVries, Marc G. Besselink, Hjalmar C. van Santvoort & Marja A. Boermeester. (2021) A Classification Algorithm for Types of Diabetes in Chronic Pancreatitis Using Epidemiological Characteristics. Pancreas 50:10, pages 1407-1414.
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Shajith Anoop, Riddhi Dasgupta, Felix K. Jebasingh, Roshna Ramachandran, Mathews Edatharayil Kurian, Grace Rebekah, K.A Balsubramanian & Nihal Thomas. (2021) Exocrine pancreatic insufficiency related fat malabsorption and its association with autonomic neuropathy in Asian Indians with type 2 diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 15:5, pages 102273.
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Lindsay E Carnie, Angela Lamarca, Kate Vaughan, Zainul Abedin Kapacee, Lynne McCallum, Alison Backen, Jorge Barriuso, Mairéad G McNamara, Richard A Hubner, Marc Abraham & Juan W Valle. (2021) Prospective observational study of prevalence, assessment and treatment of pancreatic exocrine insufficiency in patients with inoperable pancreatic malignancy (PANcreatic cancer Dietary Assessment (PanDA): a study protocol. BMJ Open 11:5, pages e042067.
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Kwan Wai Lam & John Leeds. (2021) How to manage: patient with a low faecal elastase. Frontline Gastroenterology 12:1, pages 67-73.
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Jessica J. McMaster, Graeme G. Rich, Erin R. Shanahan, Anh T. Do, Linda M. Fletcher, Marguerite J. Kutyla, Caroline Tallis, Mike P. Jones, Nicholas J. Talley, Graeme A. Macdonald, Veronique S. Chachay & Gerald J. Holtmann. (2020) Induction of Meal-related Symptoms as a Novel Mechanism of Action of the Duodenal-Jejunal Bypass Sleeve. Journal of Clinical Gastroenterology 54:6, pages 528-535.
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Salih Boga, Ali Riza Koksal, İlker Sen, Muge Kurul Yeniay, Muveddet Banu Yilmaz Ozguven, Erdinc Serin, Sukru Mehmet Erturk, Huseyin Alkim & Canan Alkim. (2020) Liver and pancreas: ‘Castor and Pollux’ regarding the relationship between hepatic steatosis and pancreas exocrine insufficiency. Pancreatology 20:5, pages 880-886.
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Benjamin Crooks, Jimmy K Limdi & John McLaughlin. (2019) How to manage chronic diarrhoea in the elderly?. Frontline Gastroenterology 10:4, pages 427-433.
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Michael D. Riceman, Michelle Bound, Jacqueline Grivell, Seva Hatzinikolas, Samuel Piotto, Nam Q. Nguyen, Karen L. Jones, Michael Horowitz, Christopher K. Rayner & Liza K. Phillips. (2019) The prevalence and impact of low faecal elastase-1 in community-based patients with type 2 diabetes. Diabetes Research and Clinical Practice 156, pages 107822.
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Mustafa Altay. (2019) Which factors determine exocrine pancreatic dysfunction in diabetes mellitus?. World Journal of Gastroenterology 25:22, pages 2699-2705.
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Susanne Kaser, Yvonne Winhofer-Stöckl, Lili Kazemi-Shirazi, Sabine E. Hofer, Helmut Brath, Harald Sourij, Greisa Vila, Heidemarie Abrahamian, Michaela Riedl, Raimund Weitgasser, Michael Resl, Martin Clodi & Anton Luger. (2019) Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2019)Other specific types of diabetes and exocrine pancreatic insufficiency (Update 2019). Wiener klinische Wochenschrift 131:S1, pages 16-26.
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Björn Lindkvist, Catarina Nilsson, Mats Kvarnström & Jan Oscarsson. (2018) Importance of pancreatic exocrine dysfunction in patients with type 2 diabetes: A randomized crossover study. Pancreatology 18:5, pages 550-558.
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Gábor Zsóri, Dóra Illés, Viktória Terzin, Emese Ivány & László Czakó. (2018) Exocrine pancreatic insufficiency in type 1 and type 2 diabetes mellitus: do we need to treat it? A systematic review. Pancreatology 18:5, pages 559-565.
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J. Enrique Domínguez-Muñoz & Beatriz Cigarrán. 2018. Gastrointestinal Complications of Diabetes. Gastrointestinal Complications of Diabetes 205 211 .
Vikesh K Singh, Mark E Haupt, David E Geller, Jerry A Hall & Pedro M Quintana Diez. (2017) Less common etiologies of exocrine pancreatic insufficiency. World Journal of Gastroenterology 23:39, pages 7059-7076.
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Víctor González-Sánchez, Rahma Amrani, Victoria González, Celia Trigo, Antonio Picó & Enrique de-Madaria. (2017) Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: 13C-Mixed Triglyceride Breath Test versus Fecal Elastase. Pancreatology 17:4, pages 580-585.
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Guanghui Pei, Wu Lv, Xiaohang Li, Guoqing Zhang & Jialin Zhang. (2017) Influence of SPK with Enteric Drainage on the Pancreatic Exocrine Function in Diabetic Patients with Uremia. International Journal of Endocrinology 2017, pages 1-8.
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Sonmoon Mohapatra, Shounak Majumder, Thomas C. Smyrk, Lizhi Zhang, Aleksey Matveyenko, Yogish C. Kudva & Suresh T. Chari. (2016) Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy. Pancreas 45:8, pages 1104-1110.
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Kadir Demir, Cetin Karaca, Emel Ahishali, Metban Mestanzade, Selda Celik, Nurdan Gul, Fulya Turker, Filiz Akyuz, Fatih Besisik & Kubilay Karsidag. (2016) A Cross-sectional Study to Assess the Prevalence of Pancreatic Exocrine Insufficiency Among Diabetes Mellitus Patients in Turkey. Pancreas 45:7, pages e39-e40.
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Wolfgang Rathmann, Burkhard Haastert, Jan Oscarsson, Niklas Berglind, Björn Lindkvist & Nicholas J. Wareham. (2016) Association of faecal elastase 1 with non-fasting triglycerides in type 2 diabetes. Pancreatology 16:4, pages 563-569.
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Ranka N. Kangrga, Svetlana D. Ignjatović, Mirjana M. Dragašević, Snežana Ž. Jovičić & Nada T. Majkić-Singh. (2016) Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus. Laboratory Medicine 47:2, pages 140-148.
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Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Sandra Zlamal-Fortunat & Heinz F. Hammer. (2016) Exokrine Pankreasinsuffizienz und Diabetes mellitusExocrine pancreatic insufficiency and diabetes mellitus. Wiener klinische Wochenschrift 128:S2, pages 163-166.
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C. Shivaprasad, Annie A. Pulikkal & K.M. Prasanna Kumar. (2015) Pancreatic exocrine insufficiency in type 1 and type 2 diabetics of Indian origin. Pancreatology 15:6, pages 616-619.
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Wolfgang Rathmann, Burkhard Haastert, Jan Oscarsson, Niklas Berglind & Nicholas J. Wareham. (2015) Inverse association of HbA1c with faecal elastase 1 in people without diabetes. Pancreatology 15:6, pages 620-625.
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Matteo Piciucchi, Gabriele Capurso, Livia Archibugi, Martina Maria Delle Fave, Marina Capasso & Gianfranco Delle Fave. (2015) Exocrine Pancreatic Insufficiency in Diabetic Patients: Prevalence, Mechanisms, and Treatment. International Journal of Endocrinology 2015, pages 1-7.
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Victoriano Pérez-Vázquez, Juan Guzmán-Flores, Daniela Mares-Álvarez, Magdalena Hernández-Ortiz, Maciste Macías-Cervantes, Joel Ramírez-Emiliano & Sergio Encarnación-Guevara. (2014) Differential Proteomic Analysis of the Pancreas of Diabetic db/db Mice Reveals the Proteins Involved in the Development of Complications of Diabetes Mellitus. International Journal of Molecular Sciences 15:6, pages 9579-9593.
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Stephanie L M Das. (2014) Relationship between the exocrine and endocrine pancreas after acute pancreatitis. World Journal of Gastroenterology 20:45, pages 17196.
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Nils Ewald & Reinhard G. Bretzel. (2013) Diabetes mellitus secondary to pancreatic diseases (Type 3c) — Are we neglecting an important disease?. European Journal of Internal Medicine 24:3, pages 203-206.
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Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Werner Fortunat & Heinz Hammer. (2012) Positionspapier: Exokrine Pankreasinsuffizienz und Diabetes mellitusPosition paper: exocrine pancreatic insufficiency and diabetes mellitus. Wiener klinische Wochenschrift 124:S2, pages 100-103.
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Yaping Xu, Deqing Wu, Yue Zeng & Xingpeng Wang. (2012) Pancreatic Exocrine Function and Morphology Following an Episode of Acute Pancreatitis. Pancreas 41:6, pages 922-927.
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Philip D. Hardt, Michael Erbach & Oliver Schnell. (2012) Hat er eine exokrine Pankreasinsuffizienz?. MMW - Fortschritte der Medizin 154:9, pages 53-55.
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N. Ewald, C. Kaufmann, A. Raspe, H. U. Kloer, R. G. Bretzel & P. D. Hardt. (2012) Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Diabetes/Metabolism Research and Reviews 28:4, pages 338-342.
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Karl-Heinz Herzig, Anna-Kaisa Purhonen, Kati M Räsänen, Joanna Idziak, Petri Juvonen, Ryszard Phillps & Jaroslaw Walkowiak. (2011) Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus. BMC Geriatrics 11:1.
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Matthew J. DiMagno & Eugene P. DiMagno. (2011) Chronic pancreatitis. Current Opinion in Gastroenterology 27:5, pages 452-459.
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John S. Leeds, Kofi Oppong & David S. Sanders. (2011) The role of fecal elastase-1 in detecting exocrine pancreatic disease. Nature Reviews Gastroenterology & Hepatology 8:7, pages 405-415.
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Philip D. Hardt & Nils Ewald. (2011) Exocrine Pancreatic Insufficiency in Diabetes Mellitus: A Complication of Diabetic Neuropathy or a Different Type of Diabetes?. Experimental Diabetes Research 2011, pages 1-7.
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James ToouliAndrew V BiankinMark R OliverCallum B PearceJeremy S WilsonNicholas H Wray. (2010) Management of pancreatic exocrine insufficiency: Australasian Pancreatic Club recommendations. Medical Journal of Australia 193:8, pages 461-467.
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Junying Han & Ye Q. Liu. (2010) Suppressed glucose metabolism in acinar cells might contribute to the development of exocrine pancreatic insufficiency in streptozotocin-induced diabetic mice. Metabolism 59:9, pages 1257-1267.
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Natércia F. Brás, Rui Gonçalves, Pedro A. Fernandes, Nuno Mateus, Maria João Ramos & Victor de Freitas. (2010) Understanding the Binding of Procyanidins to Pancreatic Elastase by Experimental and Computational Methods. Biochemistry 49:25, pages 5097-5108.
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Katherine A. FawcettEleanor WheelerAndrew P. MorrisSally L. RickettsGöran HallmansOlov RolandssonAllan DalyJon WassonAlan PermuttAndrew T. HattersleyBenjamin GlaserPaul W. FranksMark I. McCarthyNicholas J. WarehamManjinder S. SandhuInês Barroso. (2010) Detailed Investigation of the Role of Common and Low-Frequency WFS1 Variants in Type 2 Diabetes Risk . Diabetes 59:3, pages 741-746.
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Mehmet Bilgin, Numan Cem Balci, Amir Javad Momtahen, Yaşar Bilgin, Hans-Ulrich Klör & Wigbert S. Rau. (2009) MRI and MRCP Findings of the Pancreas in Patients With Diabetes Mellitus. Journal of Clinical Gastroenterology 43:2, pages 165-170.
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J. Alan Erickson, William E. Aldeen, David G. Grenache & Edward R. Ashwood. (2008) Evaluation of a fecal pancreatic elastase-1 enzyme-linked immunosorbent assay: Assessment versus an established assay and implication in classifying pancreatic function. Clinica Chimica Acta 397:1-2, pages 87-91.
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