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Research Article

Dipeptidyl Peptidase IV (DP IV, CD26) in Patients with Inflammatory Bowel Disease

Pages 1067-1072 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Aleksi Šedo, Jarmila Stremenová, Petr Bušek & Jonathan S Duke-Cohan. (2008) Dipeptidyl peptidase-IV and related molecules: markers of malignancy?. Expert Opinion on Medical Diagnostics 2:6, pages 677-689.
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N. Aguilera-Montilla, M. Pérez-Blas, A. P. Valeri, M. López-Santalla, C. Rodríguez-Juan, Á. Mencía, G. Castellano, M. L. Manzano, B. Casis, F. Sánchez & J. M. Martín-Villa. (2004) Higher proliferative capacity of T lymphocytes from patients with Crohn disease than from ulcerative colitis is disclosed by use of Herpesvirus saimiri-transformed T-cell lines. Scandinavian Journal of Gastroenterology 39:12, pages 1236-1242.
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Anne-Marie Lambeir, Christine Durinx, Simon Scharpé & Ingrid De Meester. (2003) Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV. Critical Reviews in Clinical Laboratory Sciences 40:3, pages 209-294.
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Xiaopeng Hu, Xisheng Wang & Xingkui Xue. (2022) Therapeutic Perspectives of CD26 Inhibitors in Imune-Mediated Diseases. Molecules 27:14, pages 4498.
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Tianli Zhang, Xiang Tong, Shijie Zhang, Dongguang Wang, Lian Wang, Qian Wang & Hong Fan. (2021) The Roles of Dipeptidyl Peptidase 4 (DPP4) and DPP4 Inhibitors in Different Lung Diseases: New Evidence. Frontiers in Pharmacology 12.
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Marie Villumsen, Astrid Blicher Schelde, Espen Jimenez-Solem, Tine Jess & Kristine Højgaard Allin. (2021) GLP-1 based therapies and disease course of inflammatory bowel disease. eClinicalMedicine 37, pages 100979.
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Francisco Jorge Melo, Pedro Pinto-Lopes, Maria Manuela Estevinho & Fernando Magro. (2021) The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review. Inflammatory Bowel Diseases 27:7, pages 1153-1165.
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Marvin Szklarski, Helma Freitag, Sebastian Lorenz, Sonya C. Becker, Franziska Sotzny, Sandra Bauer, Jelka Hartwig, Harald Heidecke, Kirsten Wittke, Claudia Kedor, Leif G. Hanitsch, Patricia Grabowski, Nuno Sepúlveda & Carmen Scheibenbogen. (2021) Delineating the Association Between Soluble CD26 and Autoantibodies Against G-Protein Coupled Receptors, Immunological and Cardiovascular Parameters Identifies Distinct Patterns in Post-Infectious vs. Non-Infection-Triggered Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Frontiers in Immunology 12.
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Meng-meng Ning, Wen-ji Yang, Wen-bo Guan, Yi-pei Gu, Ying Feng & Ying Leng. (2020) Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2. Acta Pharmacologica Sinica 41:11, pages 1446-1456.
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Yi-Chuan Chen, Tien-Hsing Chen, Chi-Chin Sun, Jau-Yuan Chen, Shy-Shin Chang, Ling Yeung & Yi-Wen Tsai. (2020) Dipeptidyl peptidase-4 inhibitors and the risks of autoimmune diseases in type 2 diabetes mellitus patients in Taiwan: a nationwide population-based cohort study. Acta Diabetologica 57:10, pages 1181-1192.
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Honghui Wang, Xueping Gu, Huiyuan Li, Lingmei Yin, Wei Tao, Jingxing Yu, Qiyuan Zhou, Hongli Mu, Yu Shen, Jin Yao, Lin Liu, Hui Bi, Renchi Yang & Zeping Zhou. (2020) Levels of Soluble CD30 and CD26 and Their Clinical Significance in Patients with Primary Immune Thrombocytopenia. BioMed Research International 2020, pages 1-8.
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Jong‐Mi Seong, Jeong Yee & Hye Sun Gwak. (2019) Dipeptidyl peptidase‐4 inhibitors lower the risk of autoimmune disease in patients with type 2 diabetes mellitus: A nationwide population‐based cohort study. British Journal of Clinical Pharmacology 85:8, pages 1719-1727.
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Njanja Enz, Gwendolyn Vliegen, Ingrid De Meester & Wolfgang Jungraithmayr. (2019) CD26/DPP4 - a potential biomarker and target for cancer therapy. Pharmacology & Therapeutics 198, pages 135-159.
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Liliana Valencia-Sánchez, Rafael Almendra-Pegueros, Luis Jose Diaz R-Valdez, David Esmer-Sánchez, Úrsula Medina & Antonio Gordillo-Moscoso. (2019) DPP-4 as a Possible Biomarker of Inflammation Before Abdominal Surgery for Chronic Pathology: Our Experience with Elective Cholecystectomy. Medicina 55:5, pages 148.
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Marta Olivares, Valentina Schüppel, Ahmed M. Hassan, Martin Beaumont, Audrey M. Neyrinck, Laure B. Bindels, Alfonso Benítez-Páez, Yolanda Sanz, Dirk Haller, Peter Holzer & Nathalie M. Delzenne. (2018) The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health. Frontiers in Microbiology 9.
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Suncica Buljevic, Dijana Detel, Ester P. Pugel & Jadranka Varljen. (2018) The effect of CD26‐deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease. Journal of Cellular Biochemistry 119:8, pages 6743-6755.
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Khalaf Kridin, Kyle Amber, Mogher Khamaisi, Doron Comaneshter, Erez Batat & Arnon D. Cohen. (2018) Is there an association between dipeptidyl peptidase-4 inhibitors and autoimmune disease? A population-based study. Immunologic Research 66:3, pages 425-430.
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Sucheera Chotikatum, Hassan Y. Naim & Nahed El-Najjar. (2018) Inflammation induced ER stress affects absorptive intestinal epithelial cells function and integrity. International Immunopharmacology 55, pages 336-344.
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Roger Yazbeck, Simone E. Jaenisch & Catherine A. Abbott. (2017) Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein. Protoplasma 255:1, pages 375-386.
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Hasan Saad Aldewachi, Nicola Woodroofe, Simon Turega & Philip H.E. Gardiner. (2017) Optimization of gold nanoparticle-based real-time colorimetric assay of dipeptidyl peptidase IV activity. Talanta 169, pages 13-19.
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Yuejia Song, Min Zhou, Yang Cao, Jiping Qi, Jingshu Geng & Xiaomin Liu. (2017) Expression of GLP-1 receptor and CD26 in human thyroid C-cells: The association of thyroid C-cell tumorigenesis with incretin-based medicine. Oncology Letters 13:4, pages 2684-2690.
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C Klemann, L Wagner, M Stephan & S von Hörsten. (2016) Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system. Clinical and Experimental Immunology 185:1, pages 1-21.
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Lucie Sromova, Petr Busek, Liliana Sedova & Aleksi Sedo. (2015) Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity. BMC Musculoskeletal Disorders 16:1.
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Seoyoung C Kim, Sebastian Schneeweiss, Robert J Glynn, Michael Doherty, Allison B Goldfine & Daniel H Solomon. (2015) Dipeptidyl peptidase-4 inhibitors in type 2 diabetes may reduce the risk of autoimmune diseases: a population-based cohort study. Annals of the Rheumatic Diseases 74:11, pages 1968-1975.
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Yannick Waumans, Lesley Baerts, Kaat Kehoe, Anne-Marie Lambeir & Ingrid De Meester. (2015) The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis. Frontiers in Immunology 6.
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Kaori Fujiwara, Takuya Inoue, Naoki Yorifuji, Munetaka Iguchi, Taisuke Sakanaka, Ken Narabayashi, Kazuki Kakimoto, Sadaharu Nouda, Toshihiko Okada, Kumi Ishida, Yosuke Abe, Daisuke Masuda, Toshihisa Takeuchi, Shinya Fukunishi, Eiji Umegaki, Yasutada Akiba, Jonathan D. Kaunitz & Kazuhide Higuchi. (2015) Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. Journal of Clinical Biochemistry and Nutrition 56:2, pages 155-162.
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Anna-Maria Globig, Nadine Hennecke, Bianca Martin, Maximilian Seidl, Günther Ruf, Peter Hasselblatt, Robert Thimme & Bertram Bengsch. (2014) Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease. Inflammatory Bowel Diseases 20:12, pages 2321-2329.
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Lin Yang, Jiao Yuan & Zhiguang Zhou. (2014) Emerging Roles of Dipeptidyl Peptidase 4 Inhibitors: Anti-Inflammatory and Immunomodulatory Effect and Its Application in Diabetes Mellitus. Canadian Journal of Diabetes 38:6, pages 473-479.
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Lyudmila Viktorovna Nedosugova, Nina Alexandrovna Petunina & Karina Oganesovna Galstyan. (2014) Initial investigation of efficacy and safety of a new dipeptidyl peptidase-4 inhibitor, gosogliptin, for type 2 diabetes in Russia. Diabetes mellitus 17:4, pages 81-86.
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Lucienne Juillerat-Jeanneret. (2013) Dipeptidyl Peptidase IV and Its Inhibitors: Therapeutics for Type 2 Diabetes and What Else?. Journal of Medicinal Chemistry 57:6, pages 2197-2212.
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Na-Hyung Kim, Taeyang Yu & Dae Ho Lee. (2014) The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors. BioMed Research International 2014, pages 1-10.
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Yunjuan Zhao, Lin Yang & Zhiguang Zhou. (2013) Dipeptidyl peptidase‐4 inhibitors: Multitarget drugs, not only antidiabetes drugs (D ipeptidyl peptidase ‐4抑制剂:多靶点药物,不仅仅是降糖药). Journal of Diabetes 6:1, pages 21-29.
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Dijana Detel, Ester Pernjak Pugel, Lara Baticic Pucar, Suncica Buljevic & Jadranka Varljen. (2012) Development and resolution of colitis in mice with target deletion of dipeptidyl peptidase IV. Experimental Physiology 97:4, pages 486-496.
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