57
Views
70
CrossRef citations to date
0
Altmetric
Research Article

A Polymorphism in the CD14 Gene is Associated with Crohn Disease

Pages 189-191 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Daniela F. Giachino, Silvia Regazzoni, Marco Bardessono, Mario De Marchi & Dario Gregori. (2007) Modeling the role of genetic factors in characterizing extra-intestinal manifestations in Crohn's disease patients: does this improve outcome predictions?. Current Medical Research and Opinion 23:7, pages 1657-1665.
Read now
Philippe Goyette, Catherine Labbé, Truc T. Trinh, Ramnik J. Xavier & John D. Rioux. (2007) Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine. Annals of Medicine 39:3, pages 177-199.
Read now
Kirsten E. Peters, Nathan J. O'Callaghan & Juleen A. Cavanaugh. (2005) Lack of association of the CD14 promoter polymorphism −159C/T with Caucasian inflammatory bowel disease. Scandinavian Journal of Gastroenterology 40:2, pages 194-197.
Read now
Gergely Klausz, Tamás Molnár, Ferenc Nagy, Zsófia Gyulai, Krisztina Boda, János Lonovics & Yvette Mándi. (2005) Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease. Scandinavian Journal of Gastroenterology 40:10, pages 1197-1204.
Read now

Articles from other publishers (66)

Marijana Basic, Manuela Buettner, Lydia M. Keubler, Anna Smoczek, Inga Bruesch, Stephanie Buchheister & André Bleich. (2018) Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation. Scientific Reports 8:1.
Crossref
K. F. Pearce, Y. Balavarca, J. Norden, G. Jackson, E. Holler, R. Dressel, H. Greinix, A. Toubert, E. Gluckman, I. Hromadnikova, P. Sedlacek, D. Wolff, U. Holtick, H. Bickeböller & A. M. Dickinson. (2016) Impact of genomic risk factors on survival after haematopoietic stem cell transplantation for patients with acute leukaemia. International Journal of Immunogenetics 43:6, pages 404-412.
Crossref
Yean K. Yong, Esaki M. Shankar, Ajantha Solomon, Tim Spelman, Christopher K. Fairley, Julian H. Elliott, Jennifer Hoy, Paul U. Cameron, Adeeba Kamarulzaman & Sharon R. Lewin. (2016) Polymorphisms in the CD14 and TLR4 genes independently predict CD4+ T-cell recovery in HIV-infected individuals on antiretroviral therapy. AIDS 30:14, pages 2159-2168.
Crossref
Y Balavarca, K Pearce, J Norden, M Collin, G Jackson, E Holler, R Dressel, H-J Kolb, H Greinix, G Socie, A Toubert, V Rocha, E Gluckman, I Hromadnikova, P Sedlacek, D Wolff, U Holtick, A Dickinson & H Bickeböller. (2015) Predicting survival using clinical risk scores and non-HLA immunogenetics. Bone Marrow Transplantation 50:11, pages 1445-1452.
Crossref
Yiqun Hu, Kengo Yoshida, John B Cologne, Mayumi Maki, Yukari Morishita, Keiko Sasaki, Ikue Hayashi, Waka Ohishi, Ayumi Hida, Seishi Kyoizumi, Yoichiro Kusunoki, Katsushi Tokunaga, Kei Nakachi & Tomonori Hayashi. (2015) CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors. Human Genome Variation 2:1.
Crossref
Regina Schey, Claudia Danzer & Jochen Mattner. (2015) Perturbations of mucosal homeostasis through interactions of intestinal microbes with myeloid cells. Immunobiology 220:2, pages 227-235.
Crossref
Isabela N. Rôças, José F. SiqueiraJr.Jr., Camila A. Del Aguila, José C. Provenzano, Bianca P.S. Guilherme & Lucio S. Gonçalves. (2014) Polymorphism of the CD14 and TLR4 Genes and Post-treatment Apical Periodontitis. Journal of Endodontics 40:2, pages 168-172.
Crossref
Ergin Ayaslioglu, Fusun Kalpaklioglu, Ayse Baccioglu Kavut, Arzu Erturk, Nermin Capan & Esra Birben. (2013) The role of CD14 gene promoter polymorphism in tuberculosis susceptibility. Journal of Microbiology, Immunology and Infection 46:3, pages 158-163.
Crossref
Marja L. Laine, Wim Crielaard & Bruno G. Loos. (2011) Genetic susceptibility to periodontitis. Periodontology 2000 58:1, pages 37-68.
Crossref
Eun Jung KimWoo Chul ChungKang-Moon LeeChang Nyol PaikSung Hoon JungBo In LeeHiun Suk ChaeKyu Yong Choi. (2012) Association Between Toll-Like Receptors/ CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population . Journal of Korean Medical Science 27:1, pages 72.
Crossref
Shu-Chen Wei, Yen-Hsuan Ni, Hwai-I. Yang, Yi-Nin Su, Ming-Chu Chang, Yu-Ting Chang, Ming-Jium Shieh, Cheng-Yi Wang & Jau-Min Wong. (2011) A hospital-based study of clinical and genetic features of Crohn’s disease. Journal of the Formosan Medical Association 110:9, pages 600-606.
Crossref
Jamal A. Mohamed, Herbert L. DuPont, Jose Flores, Himaja Palur, Parvathy Nair, Zhi-Dong Jiang, Dongchuan Guo, Jaime Belkind-Gerson & Pablo C. Okhuysen. (2011) Single Nucleotide Polymorphisms in the Promoter of the Gene Encoding the Lipopolysaccharide Receptor CD14 Are Associated With Bacterial Diarrhea in US and Canadian Travelers to Mexico. Clinical Infectious Diseases 52:11, pages 1332-1341.
Crossref
Si Ming Man, Nadeem O. Kaakoush & Hazel M. Mitchell. (2011) The role of bacteria and pattern-recognition receptors in Crohn's disease. Nature Reviews Gastroenterology & Hepatology 8:3, pages 152-168.
Crossref
Peter Laszlo Lakatos, Lajos Sandor Kiss, Karoly Palatka, Istvan Altorjay, Peter Antal-Szalmas, Eszter Palyu, Miklos Udvardy, Tamas Molnar, Klaudia Farkas, Gabor Veres, Jolan Harsfalvi, Janos Papp & Maria Papp. (2011) Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohnʼs disease. Inflammatory Bowel Diseases 17:3, pages 767-777.
Crossref
Fransisca Leonard, Eva-Maria Collnot & Claus-Michael Lehr. (2010) A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro. Molecular Pharmaceutics 7:6, pages 2103-2119.
Crossref
Zvi G. Fridlender, Asaf Schwartz, Martin Kohan, Gail Amir, Mendel Glazer & Neville Berkman. (2010) Association between CD14 gene polymorphisms and disease phenotype in sarcoidosis. Respiratory Medicine 104:9, pages 1336-1343.
Crossref
Maria T. Abreu, Masayuki Fukata & Keith Breglio. 2010. Inflammatory Bowel Disease. Inflammatory Bowel Disease 64 81 .
Claudia Huebner, Ivonne Petermann, Wen Jiun Lam, Andrew N. Shelling & Lynnette R. Ferguson. (2010) Characterization of single-nucleotide polymorphisms relevant to inflammatory bowel disease in commonly used gastrointestinal cell lines. Inflammatory Bowel Diseases 16:2, pages 282-295.
Crossref
Marja L. Laine, Bruno G. Loos & W. Crielaard. (2010) Gene Polymorphisms in Chronic Periodontitis. International Journal of Dentistry 2010, pages 1-22.
Crossref
Young Ae Kang, Hye Won Lee, Young Whan Kim, Sung Koo Han, Young-Soo Shim & Jae-Joon Yim. (2009) Association between the — 159C/T CD14 gene polymorphism and tuberculosis in a Korean population . FEMS Immunology & Medical Microbiology 57:3, pages 229-235.
Crossref
Maike F. de Buhr, Hans J. Hedrich, Astrid M. Westendorf, Florian Obermeier, Claudia Hofmann, Nils H. Zschemisch, Jan Buer, Dirk Bumann, Sanna M. Goyert & Andre Bleich. (2009) Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Inflammatory Bowel Diseases 15:12, pages 1824-1836.
Crossref
HUA SONG ZENG, XIANG YUAN CHEN & XIAO PING LUO. (2009) The Association with the −159C/T Polymorphism in the Promoter Region of the CD14 Gene and Juvenile Idiopathic Arthritis in a Chinese Han Population. The Journal of Rheumatology 36:9, pages 2025-2028.
Crossref
Ivonne Petermann, Claudia Huebner, Brian L. Browning, Richard B. Gearry, Murray L. Barclay, Martin Kennedy, Rebecca Roberts, Andrew N. Shelling, Martin Philpott, Dug Yeo Han & Lynnette R. Ferguson. (2009) Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Human Immunology 70:6, pages 440-446.
Crossref
Farooq Z. Rahman, Daniel J.B. Marks, Bu H. Hayee, Andrew M. Smith, Stuart L. Bloom & Anthony W. Segal. (2008) Phagocyte dysfunction and inflammatory bowel disease. Inflammatory Bowel Diseases 14:10, pages 1443-1452.
Crossref
A Dezsőfi, B Szebeni, CS Hermann, A Kapitány, G Veres, S Sipka, A Körner, L Madácsy, I Korponay-Szabó, K Rajczy & A Arató. (2008) Frequencies of Genetic Polymorphisms of TLR4 and CD14 and of HLA-DQ Genotypes in Children With Celiac Disease, Type 1 Diabetes Mellitus, or Both. Journal of Pediatric Gastroenterology & Nutrition 47:3, pages 283-287.
Crossref
Wei Gu, Hong Dong, Dong-Po Jiang, Jian Zhou, Ding-Yuan Du, Jin-Mou Gao, Yuan-Zhang Yao, Lian-Yang Zhang, Ai-Qing Wen, Qing Liu, Zheng-Guo Wang & Jian-Xin Jiang. (2008) Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population*. Critical Care Medicine 36:8, pages 2274-2280.
Crossref
Ari Silbermintz, Jeremiah Levine, Toba Weinstein & Jack Silver. (2008) Polymorphisms in the Tumor Necrosis Factor/Lipopolysaccharides Pathway in Crohn Disease in the Jewish Ashkenazi Population. Journal of Pediatric Gastroenterology & Nutrition 46:5, pages 546-550.
Crossref
P. L. Lakatos. 2008. Pathogenesis and Clinical Practice in Gastroenterology. Pathogenesis and Clinical Practice in Gastroenterology 43 75 .
Adrian G. Rosas‐Taraco, Agnès Revol, Mario C. Salinas‐Carmona, Adrian Rendon, Guillermo Caballero‐Olin & Alma Y. Arce‐Mendoza. (2007) CD14 C(−159)T Polymorphism Is a Risk Factor for Development of Pulmonary Tuberculosis. The Journal of Infectious Diseases 196:11, pages 1698-1706.
Crossref
Jiwon Hong, Euphemia Leung, Alan G Fraser, Tony R Merriman, Prakash Vishnu & Geoffrey W Krissansen. (2007) TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. Journal of Gastroenterology and Hepatology 22:11, pages 1760-1766.
Crossref
Fangyu Wang, Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Hiroshi Fujita, Masami Iwata, Yoshio Kamiya, Mitsuo Nagasaka, Kazuya Takahama, Makoto Watanabe, Ichiro Hirata & Hiroshi Nakano. (2007) Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis. Journal of Gastroenterology and Hepatology 22:6, pages 925-929.
Crossref
Johan Van Limbergen, Richard K. Russell, Elaine R. Nimmo, Gwo-Tzer Ho, Ian D. Arnott, David C. Wilson & Jack Satsangi. (2007) Genetics of the innate immune response in inflammatory bowel disease. Inflammatory Bowel Diseases 13:3, pages 338-355.
Crossref
Jacqueline A. James, Kay V. Poulton, Simone E. Haworth, Debbie Payne, Ian J. McKay, Fiona M. Clarke, Francis J. Hughes & Gerard J. Linden. (2007) Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis. Journal of Clinical Periodontology 34:2.
Crossref
Daniel C. Baumgart, Carsten Büning, Lars Geerdts, Hartmut H. Schmidt, Janine Genschel, Thomas Fiedler, Enno Gentz, Tomas Molnar, Ferenc Nagy, Janos Lonovics, Herbert Lochs, Bertram Wiedenmann, Renate Nickel, Heiko Witt & Axel Dignass. (2007) The c.1-260C>T Promoter Variant of CD14 but Not the c.896A>G (p.D299G) Variant of Toll-Like Receptor 4 (TLR4) Genes Is Associated with Inflammatory Bowel Disease. Digestion 76:3-4, pages 196-202.
Crossref
Kathrin S Michelsen & Moshe Arditi. (2007) Toll-like receptors and innate immunity in gut homeostasis and pathology. Current Opinion in Hematology 14:1, pages 48-54.
Crossref
Ikuko Kato, Federico Canzian, Martyn Plummer, Silvia Franceschi, Leen-Jan van Doorn, Jorge Vivas, Gladys Lopez, Yanhui Lu, Lydie Gioia-Patricola, Richard K. Severson, Ann G. Schwartz & Nubia Muñoz. (2006) Polymorphisms in Genes Related to Bacterial Lipopolysaccharide/Peptidoglycan Signaling and Gastric Precancerous Lesions in a Population at High Risk for Gastric Cancer. Digestive Diseases and Sciences 52:1, pages 254-261.
Crossref
A.H. Werners, S. Bull, J.C. Vendrig, T. Smyth, R.R. Bosch, J. Fink-Gremmels & C.E. Bryant. (2006) Genotyping of Toll-like receptor 4, myeloid differentiation factor 2 and CD-14 in the horse: An investigation into the influence of genetic polymorphisms on the LPS induced TNF-α response in equine whole blood. Veterinary Immunology and Immunopathology 111:3-4, pages 165-173.
Crossref
Maike F. de Buhr, Michael Mähler, Robert Geffers, Wiebke Hansen, Astrid M. Westendorf, Jörg Lauber, Jan Buer, Brigitte Schlegelberger, Hans J. Hedrich & Andre Bleich. (2006) Cd14 , Gbp1 , and Pla2g2a : three major candidate genes for experimental IBD identified by combining QTL and microarray analyses . Physiological Genomics 25:3, pages 426-434.
Crossref
Daniel JB Marks, Marcus WN Harbord, Raymond MacAllister, Farooq Z Rahman, Jodi Young, Bissan Al-Lazikani, William Lees, Marco Novelli, Stuart Bloom & Anthony W Segal. (2006) Defective acute inflammation in Crohn's disease: a clinical investigation. The Lancet 367:9511, pages 668-678.
Crossref
Christian U Riedel. (2006) Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation. World Journal of Gastroenterology 12:23, pages 3729.
Crossref
Peter Laszlo Lakatos. (2006) Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take “toll”. World Journal of Gastroenterology 12:12, pages 1829.
Crossref
QIUSHA GUO, JIANBO ZHU & BING XIA. (2006) Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients . Journal of Gastroenterology and Hepatology 21:1, pages 92-97.
Crossref
Masayuki Fukata & Maria T. Abreu. 2005. Toll-like Receptors in Inflammation. Toll-like Receptors in Inflammation 107 123 .
D. J. B. Marks, N. A. Mitchison, A. W. Segal & J. Sieper. 2006. Current Concepts in Autoimmunity and Chronic Inflammation. Current Concepts in Autoimmunity and Chronic Inflammation 105 125 .
Sonja EN Wagenleiter, Peter Jagiello, Denis A Akkad, Larissa Arning, Thomas Griga, Wolfram Klein & Jörg T Epplen. (2005) On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors. Journal of Negative Results in BioMedicine 4:1.
Crossref
Keiko Yamazaki, Dermot McGovern, Jiannis Ragoussis, Marta Paolucci, Helen Butler, Derek Jewell, Lon Cardon, Masakazu Takazoe, Torao Tanaka, Toshiki Ichimori, Susumu Saito, Akihiro Sekine, Aritoshi Iida, Atsushi Takahashi, Tatsuhiko Tsunoda, Mark Lathrop & Yusuke Nakamura. (2005) Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Human Molecular Genetics 14:22, pages 3499-3506.
Crossref
S. E. N. Wagenleiter, W. Klein, T. Griga, W. Schmiegel, J. T. Epplen & P. Jagiello. (2005) A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease. International Journal of Immunogenetics 32:5, pages 323-324.
Crossref
Bruno G. Loos, Raymond P. John & Marja L. Laine. (2005) Identification of genetic risk factors for periodontitis and possible mechanisms of action. Journal of Clinical Periodontology 32:s6, pages 159-179.
Crossref
Euphemia Leung, Jiwon Hong, Alan G Fraser, Tony R Merriman, Prakash Vishnu, William GH Abbott & Geoffrey W Krissansen. (2005) Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients . Immunology & Cell Biology 83:5, pages 498-503.
Crossref
Hsiang-Hung Shih, Tsun-Mei Lin, Jiin-Haur Chuang, Hock-Liew Eng, Suh-Hang Hank Juo, Fu-Chen Huang, Chao-Long Chen & Huey-Ling Chen. (2005) Promoter Polymorphism of the CD14 Endotoxin Receptor Gene Is Associated With Biliary Atresia and Idiopathic Neonatal Cholestasis. Pediatrics 116:2, pages 437-441.
Crossref
F Lanzarotto, A Akbar & S Ghosh. (2005) Does innate immune response defect underlie inflammatory bowel disease in the Asian population?. Postgraduate Medical Journal 81:958, pages 483-485.
Crossref
Q S Guo, B Xia, Y Jiang, S A Morré, L Cheng, J Li, J B A Crusius & A S Peña. (2005) Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients. Postgraduate Medical Journal 81:958, pages 526-529.
Crossref
Attila Balog, Zsolt Gyulai, Laszlo G Boros, Gyula Farkas, Tamas Takács, Janos Lonovics & Yvette Mándi. (2005) Polymorphism of the TNF-α, HSP70-2, and CD14 Genes Increases Susceptibility to Severe Acute Pancreatitis. Pancreas 30:2, pages e46-e50.
Crossref
Maria Gazouli. (2005) Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population . World Journal of Gastroenterology 11:5, pages 681.
Crossref
KM Lammers. (2005) Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis . World Journal of Gastroenterology 11:46, pages 7323.
Crossref
Fraser J.R. Cummings & Derek P. Jewell. (2005) Clinical Implications of Inflammatory Bowel Disease Genetics on Phenotype. Inflammatory Bowel Diseases 11:1, pages 56-61.
Crossref
Adriana Zapata-Velandia, San-San Ng, Rebecca F Brennan, Neal R Simonsen, Mariella Gastanaduy, Jovanny Zabaleta, Jennifer J Lentz, Randall D Craver, Hernan Correa, Alberto Delgado, Angela L Pitts, Jane R Himel, John N UdallJrJr, Eberhard Schmidt-Sommerfeld, Raynorda F Brown, Grace B Athas, Bronya B Keats & Elizabeth E Mannick. (2004) Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn's disease: a case-control study. Journal of Immune Based Therapies and Vaccines 2:1.
Crossref
Matthias Folwaczny, Jurgen Glas, Helga-Paula Torok, Kathinka Fricke & Christian Folwaczny. (2004) The CD14 -159C-to-T promoter polymorphism in periodontal disease. Journal of Clinical Periodontology 31:11, pages 991-995.
Crossref
I D R Arnott, E R Nimmo, H E Drummond, J Fennell, B R K Smith, E MacKinlay, J Morecroft, N Anderson, D Kelleher, M O'Sullivan, R McManus & J Satsangi. (2004) NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?. Genes & Immunity 5:5, pages 417-425.
Crossref
Helga-Paula Török, Jürgen Glas, Laurian Tonenchi, Thomas Mussack & Christian Folwaczny. (2004) Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. Clinical Immunology 112:1, pages 85-91.
Crossref
Douglas R. Dixon, Brian W. Bainbridge & Richard P. Darveau. (2004) Modulation of the innate immune response within the periodontium. Periodontology 2000 35:1, pages 53-74.
Crossref
Karin Geleijns, Bart C Jacobs, Wouter Van Rijs, Anne P Tio-Gillen, Jon D Laman & Pieter A van Doorn. (2004) Functional polymorphisms in LPS receptors CD14 and TLR4 are not associated with disease susceptibility or Campylobacter jejuni infection in Guillain–Barré patients. Journal of Neuroimmunology 150:1-2, pages 132-138.
Crossref
Eugenia Pacheco, Carolina Fonseca, Carlos Montes, Jovanny Zabaleta, Luis F García & Mauricio A Arias. (2004) CD14 gene promoter polymorphism in different clinical forms of tuberculosis. FEMS Immunology & Medical Microbiology 40:3, pages 207-213.
Crossref
Balfour R. Sartor. (2003) Targeting enteric bacteria in treatment of inflammatory bowel diseases. Current Opinion in Gastroenterology 19:4, pages 358-365.
Crossref
T. Ahmad, Sara Marshall & Derek Jewell. (2003) Genotype-based phenotyping heralds a new taxonomy for inflammatory bowel disease. Current Opinion in Gastroenterology 19:4, pages 327-335.
Crossref
P. Rutgeerts, S. Van Deventer & S. Schreiber. (2003) The expanding role of biological agents in the treatment of inflammatory bowel disease - focus on selective adhesion molecule inhibition. Alimentary Pharmacology & Therapeutics 17:12, pages 1435-1450.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.