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ORIGINAL ARTICLE

HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease

, MD , PhD, , , , , , & show all
Pages 48-53 | Received 04 Apr 2006, Published online: 08 Jul 2009

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Read on this site (4)

Tian Shi, Weidong Liu, Ting Li, Huan Liu, Wenjia Hui, Qiang Lin, Xiaojiang Han & Feng Gao. (2023) HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest China. Scandinavian Journal of Gastroenterology 58:5, pages 471-476.
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Carmen M. Cabrera, Lorenzo Sánchez-Godoy & Víctor M. Navas-López. (2019) Is the double gene dose of DQ2.5 or DQ2.5/DQ2.2 an involved factor in the clinical features of celiac disease?. Scandinavian Journal of Gastroenterology 54:8, pages 960-964.
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Harry J. Thomas, Tariq Ahmad, Chandima Rajaguru, Martin Barnardo, Bryan F. Warren & Derek P. Jewell. (2009) Contribution of histological, serological, and genetic factors to the clinical heterogeneity of adult-onset coeliac disease. Scandinavian Journal of Gastroenterology 44:9, pages 1076-1083.
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Beatrijs A. N. Vermeulen, Caroline E. Hogen Esch, Zehre Yüksel, Frits Koning, Willem Verduijn, Ilias I. N. Doxiadis, Geziena M. TH. Schreuder & M. Luisa Mearin. (2009) Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect. Scandinavian Journal of Gastroenterology 44:1, pages 40-45.
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Articles from other publishers (25)

Aslı Eldem, Tülay Kılıçaslan Ayna, Maşallah Baran, Mustafa Soyöz & İbrahim Pirim. (2021) Determination of High-Resolution HLA-DQB1 Suballeles and IL-17 Polymorphisms in Turkish Pediatric Patients. Journal of Pediatric Genetics 11:03, pages 192-197.
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J. A. Tye‐Din. (2022) Review article: Follow‐up of coeliac disease. Alimentary Pharmacology & Therapeutics 56:S1.
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Carlo Tolone, Marisa Piccirillo, Pasquale Dolce, Salvatore Alfiero, Mattia Arenella, Marina Sarnataro, Patrizia Iardino, Alessia Pucciarelli & Caterina Strisciuglio. (2021) Celiac disease in pediatric patients according to HLA genetic risk classes: a retrospective observational study. Italian Journal of Pediatrics 47:1.
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Enrico Schirru, Rita Désirée Jores, Rossano Rossino, Mara Corpino, Francesco Cucca & Mauro Congia. (2021) Low-Risk Human Leukocyte Antigen Genes and Mild Villous Atrophy Typify Celiac Disease With Immunoglobulin A Deficiency. Journal of Pediatric Gastroenterology & Nutrition 72:6, pages 889-893.
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Fatma DEMİRBAŞ, Aslıhan SANRI, Gönül DİNLER ÇALTEPE, Atakan COMBA & Ayhan Gazi  KALAYCI. (2021) Çölyak Hastalığının Genetik Allel Dağılımının Değerlendirilmesi ve Türkiye Literatür TaramasıEvaluation of the Celiac Disease Genetic Allel Distribution and Literature Review of Turkey. Kocaeli Üniversitesi Sağlık Bilimleri Dergisi 7:1, pages 22-26.
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Laura Espino & Concepción Núñez. 2021. Immunopathology of Celiac Disease. Immunopathology of Celiac Disease 47 83 .
Eva Martínez-Ojinaga, Marta Fernández-Prieto, Manuel Molina, Isabel Polanco, Elena Urcelay & Concepción Núñez. (2019) Influence of HLA on clinical and analytical features of pediatric celiac disease. BMC Gastroenterology 19:1.
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Judit Bajor, Zsolt Szakács, Márk Juhász, Mária Papp, Dorottya Kocsis, Éva Szegedi, Ildikó Földi, Nelli Farkas, Péter Hegyi & Áron Vincze. (2019) HLA‐DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of coeliac disease: A multicentre study. International Journal of Immunogenetics 46:2, pages 74-81.
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Judit Bajor, Zsolt Szakács, Nelli Farkas, Péter Hegyi, Anita Illés, Margit Solymár, Erika Pétervári, Márta Balaskó, Gabriella Pár, Patrícia Sarlós, Ákos Szűcs, József Czimmer, Kata Szemes, Orsolya Huszár, Péter Varjú & Áron Vincze. (2019) Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis. PLOS ONE 14:2, pages e0212329.
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Bing Liu, Tuo Deng, Linxin Zhu & Jingxiang Zhong. (2018) Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt–Koyanagi–Harada disease. Medicine 97:7, pages e9914.
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A. A. Karpov, L. S. Oreshko, A. N. Pashinin & Z. M. Tskhovrebova. (2018) The morphological and functional features of the cells in the nasal secretions of the patients presenting with celiac disease and concomitant chronic upper respiratory tract pathologies. Rossiiskaya rinologiya 26:1, pages 32.
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Maria Grazia Clemente, Fulvia Frau, Matilde Bernasconi, Maria Doloretta Macis, Lucia Cicotto, Giampaolo Pilleri, Stefano De Virgiliis, Paolo Castiglia & Patrizia Farci. (2017) Distinctive HLA‐II association with primary biliary cholangitis on the Island of Sardinia. United European Gastroenterology Journal 5:4, pages 527-531.
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Daniel AgardhHye-Seung LeeKalle KurppaVille SimellCarin Andrén AronssonOla JörneusMichael HummelEdwin Liu & Sibylle Koletzko. (2015) Clinical Features of Celiac Disease: A Prospective Birth Cohort. Pediatrics 135:4, pages 627-634.
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Ennio Bramanti, Marco Cicciù, Giada Matacena, Stefano Costa & Giuseppe Magazzù. (2014) Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study. Gastroenterology Research and Practice 2014, pages 1-9.
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Hussein Abu Daya, Benjamin Lebwohl, Suzanne K. Lewis & Peter H. Green. (2013) Celiac Disease Patients Presenting With Anemia Have More Severe Disease Than Those Presenting With Diarrhea. Clinical Gastroenterology and Hepatology 11:11, pages 1472-1477.
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M. Erriu, G. M. Abbate, F. M. G. Pili, F. Novara, G. Orrù, C. Montaldo, V. Piras & L. Levrini. (2013) Oral Signs and HLA-DQB1*02 Haplotypes in the Celiac Paediatric Patient: A Preliminary Study. Autoimmune Diseases 2013, pages 1-5.
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Anna Licata, Maria Cappello, Andrea Arini, Ada M. Florena, Claudia Randazzo, Giuseppe Butera, Piero L. Almasio & Antonio Craxì. (2011) Serology in adults with celiac disease: limited accuracy in patients with mild histological lesions. Internal and Emergency Medicine 7:4, pages 337-342.
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Federico Biagi, Paola I. Bianchi, Claudia Vattiato, Alessandra Marchese, Lucia Trotta, Carla Badulli, Annalisa De Silvestri, Miryam Martinetti & Gino R. Corazza. (2012) Influence of HLA-DQ2 and DQ8 on Severity in Celiac Disease. Journal of Clinical Gastroenterology 46:1, pages 46-50.
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Nguyen Tien Huy, Mohamed Hamada, Mihoko Kikuchi, Nguyen Thi Phuong Lan, Michio Yasunami, Javier Zamora & Kenji Hirayama. (2011) Association of HLA and post-schistosomal hepatic disorder: A systematic review and meta-analysis. Parasitology International 60:4, pages 347-356.
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Matteo Erriu, Serena Sanna, Annalisa Nucaro, Germano Orrù, Valentino Garau & Caterina Montaldo. (2011) HLA-DQB1 Haplotypes and their Relation to Oral Signs Linked to Celiac Disease Diagnosis. The Open Dentistry Journal 5:1, pages 174-178.
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Alejandra Parada, Magdalena Araya, Francisco Pérez-Bravo, Marco Méndez, Adriana Mimbacas, Patricia Motta, Gabriela Martín, Jorge Botero, Nelly Espinosa, Teresa Alarcon & Paulina Canales. (2011) Amerindian mtDNA Haplogroups and Celiac Disease Risk HLA Haplotypes in Mixed-blood Latin American Patients. Journal of Pediatric Gastroenterology & Nutrition 53:4, pages 429-434.
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Lilia Laadhar, Amina Toumi, Maryam Kallel-Sellami, Mondher Zitouni, Saadia Bouraoui, Ahmed Maherzi, Sondès Makni & Mongi Ben Hariz. (2009) HLA class II polymorphism in children with coeliac disease in Tunisia: is there any influence on clinical manifestation?. European Journal of Gastroenterology & Hepatology 21:11, pages 1286-1290.
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Andrea Cassinotti, Sarah Birindelli, Mario Clerici, Daria Trabattoni, Marco Lazzaroni, Sandro Ardizzone, Riccardo Colombo, Edoardo Rossi & Gabriele Bianchi Porro. (2008) HLA and Autoimmune Digestive Disease: A Clinically Oriented Review for Gastroenterologists. The American Journal of Gastroenterology 104:1, pages 195-217.
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M. L. HAINES, R. P. ANDERSON & P. R. GIBSON. (2008) Systematic review: the evidence base for long-term management of coeliac disease. Alimentary Pharmacology & Therapeutics 28:9, pages 1042-1066.
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John M Hutchinson, Gerry Robins & Peter D Howdle. (2008) Advances in coeliac disease. Current Opinion in Gastroenterology 24:2, pages 129-134.
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