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ORIGINAL ARTICLE

Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate

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Pages 814-820 | Received 18 Sep 2006, Published online: 08 Jul 2009

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Read on this site (3)

Rasmus Fuglsang-Nielsen, Jakob Starup-Linde, Søren Gregersen & Peter Vestergaard. (2018) The effect of meals on bone turnover - a systematic review with focus on diabetic bone disease. Expert Review of Endocrinology & Metabolism 13:5, pages 233-249.
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Ida B. Gottschalck, Palle B. Jeppesen, Bolette Hartmann, Jens J. Holst & Dennis B. Henriksen. (2008) Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. Scandinavian Journal of Gastroenterology 43:11, pages 1304-1310.
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Ida B. Gottschalck, Palle B. Jeppesen, Jens J. Holst & Dennis B. Henriksen. (2008) Reduction in bone resorption by exogenous glucagon-like peptide-2 administration requires an intact gastrointestinal tract. Scandinavian Journal of Gastroenterology 43:8, pages 929-937.
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Articles from other publishers (33)

Asif Ali, Peter R Flatt & Nigel Irwin. (2024) Gut-Derived Peptide Hormone Analogues and Potential Treatment of Bone Disorders in Obesity and Diabetes Mellitus. Clinical Medicine Insights: Endocrinology and Diabetes 17.
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Bolette Hartmann, Miriam Longo, David S Mathiesen, Kristine J Hare, Niklas R Jørgensen, Katherine Esposito, Carolyn F Deacon, Tina Vilsbøll, Jens J Holst & Filip K Knop. (2024) Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism 109:1, pages e259-e265.
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Samuel S. Urlacher, Elizabeth Y. Kim, Tiffany Luan, Lauren J. Young & Brian Adjetey. (2022) Minimally invasive biomarkers in human and non‐human primate evolutionary biology: Tools for understanding variation and adaptation. American Journal of Human Biology 34:11.
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A. Kreitman, S. H. Schneider, L. Hao, Y. Schlussel, N. T. Bello & S. A. Shapses. (2021) Reduced postprandial bone resorption and greater rise in GLP-1 in overweight and obese individuals after an α-glucosidase inhibitor: a double-blinded randomized crossover trial. Osteoporosis International 32:7, pages 1379-1386.
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Alessandra Amato, Patrizia Proia, Gaetano Felice Caldara, Angelina Alongi, Vincenzo Ferrantelli & Sara Baldassano. (2021) Analysis of Body Perception, Preworkout Meal Habits and Bone Resorption in Child Gymnasts. International Journal of Environmental Research and Public Health 18:4, pages 2184.
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Julie Abildgaard, Thorkil Ploug, Anette Tønnes Pedersen, Pia Eiken, Bente Klarlund Pedersen, Jens Juul Holst, Bolette Hartmann & Birgitte Lindegaard. (2021) Preserved postprandial suppression of bone turnover markers, despite increased fasting levels, in postmenopausal women. Bone 143, pages 115612.
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Rasmus Fuglsang-Nielsen, Elin Rakvaag, Peter Vestergaard, Bolette Hartmann, Jens Juul Holst, Kjeld Hermansen, Søren Gregersen & Jakob Starup-Linde. (2020) Consumption of nutrients and insulin resistance suppress markers of bone turnover in subjects with abdominal obesity. Bone 133, pages 115230.
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Jessie A. Elliott, Sean Casey, Conor F. Murphy, Neil G. Docherty, Narayanasamy Ravi, Peter Beddy, John V. Reynolds & Carel W. le Roux. (2019) Risk factors for loss of bone mineral density after curative esophagectomy. Archives of Osteoporosis 14:1.
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Sara Baldassano, Lærke Smidt Gasbjerg, Hüsün Sheyma Kizilkaya, Mette Marie Rosenkilde, Jens Juul Holst & Bolette Hartmann. (2019) Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats. Frontiers in Endocrinology 10.
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Katarina T. Borer, Qingyun Zheng, Akram Jafari, Saba Javadi & Thomas Kernozek. (2019) Nutrient Intake Prior to Exercise Is Necessary for Increased Osteogenic Marker Response in Diabetic Postmenopausal Women. Nutrients 11:7, pages 1494.
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Bing'er Xu, Yuting He, Yi Lu, Weiying Ren, Jiping Shen, Kefen Wu, Kan Xu, Jiayu Wu & Yu Hu. (2019) Glucagon like peptide 2 has a positive impact on osteoporosis in ovariectomized rats. Life Sciences 226, pages 47-56.
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Sine Paasch Schiellerup, Kirsa Skov-Jeppesen, Johanne Agerlin Windeløv, Maria Saur Svane, Jens Juul Holst, Bolette Hartmann & Mette Marie Rosenkilde. (2019) Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment. Frontiers in Endocrinology 10.
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Stan R. Ursem, Marc G. Vervloet, Rahel M. Büttler, Mariëtte T. Ackermans, Mirjam M. Oosterwerff, Elisabeth M.V. Eekhoff, Paul Lips, Mireille J. Serlie, Susanne E. la Fleur & Annemieke C. Heijboer. (2018) The interrelation between FGF23 and glucose metabolism in humans. Journal of Diabetes and its Complications 32:9, pages 845-850.
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Jakob Starup-Linde, Sidse Westberg-Rasmussen, Simon Lykkeboe & Peter Vestergaard. 2017. Biomarkers in Bone Disease. Biomarkers in Bone Disease 1105 1128 .
Laura S Girão Lopes, Rubens Prado Schwartz, Bruno Ferraz-de-Souza, Maria Elizabeth Rossi da Silva, Pedro Henrique Silveira Corrêa & Márcia Nery. (2015) The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus. Diabetology & Metabolic Syndrome 7:1.
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Jakob Starup-Linde, Sidse Westberg-Rasmussen, Simon Lykkeboe & Peter Vestergaard. 2016. Biomarkers in Bone Disease. Biomarkers in Bone Disease 1 25 .
Verena Schwetz, Elisabeth Lerchbaum, Natascha Schweighofer, Nicole Hacker, Olivia Trummer, Olivier Borel, Thomas R. Pieber, Roland Chapurlat & Barbara Obermayer-Pietsch. (2014) Osteocalcin Levels on Oral Glucose Load in Women being Investigated for Polycystic Ovary Syndrome. Endocrine Practice 20:1, pages 5-14.
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Jonathan P.R. Scott, Craig Sale, Julie P. Greeves, Anna Casey, John Dutton & William D. Fraser. (2012) Effect of fasting versus feeding on the bone metabolic response to running. Bone 51:6, pages 990-999.
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F Folli, B N Sabowitz, W Schwesinger, P Fanti, R Guardado-Mendoza & G Muscogiuri. (2012) Bariatric surgery and bone disease: from clinical perspective to molecular insights. International Journal of Obesity 36:11, pages 1373-1379.
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Mathijs C. BUNCK, Marieke POELMA, E. Marelise EEKHOFF, Anja SCHWEIZER, Robert J. HEINE, Giel NIJPELS, James E. FOLEY & Michaela DIAMANT. (2012) Effects of vildagliptin on postprandial markers of bone resorption and calcium homeostasis in recently diagnosed, well‐controlled type 2 diabetes patients*. Journal of Diabetes 4:2, pages 181-185.
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P. M. Paldánius, K. K. Ivaska, P. Hovi, S. Andersson, H. K. Väänänen, E. Kajantie & O. Mäkitie. (2011) The Effect of Oral Glucose Tolerance Test on Serum Osteocalcin and Bone Turnover Markers in Young Adults. Calcified Tissue International 90:2, pages 90-95.
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Gábor Winkler. (2011) The physiology of incretins. Orvosi Hetilap 152:48, pages 1922-1930.
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Kim Henriksen, Claus Christiansen & Morten Asser Karsdal. (2011) Serological biochemical markers of surrogate efficacy and safety as a novel approach to drug repositioning. Drug Discovery Today 16:21-22, pages 967-975.
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Timo Rantalainen, M. Hoffrén, V. Linnamo, A. Heinonen, P. V. Komi, J. Avela & B. C. Nindl. (2011) Three-month bilateral hopping intervention is ineffective in initiating bone biomarker response in healthy elderly men. European Journal of Applied Physiology 111:9, pages 2155-2162.
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Virginia Ruiz-Esquide, Pilar Peris, Laia Gifre & Nuria Guañabens. (2011) Alteraciones del metabolismo óseo en la cirugía bariátrica. Medicina Clínica 136:5, pages 215-221.
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Manal O Elnenaei, Rebecca Musto, Jamshid Alaghband-Zadeh, Caje Moniz & Carel W Le Roux. (2010) Postprandial bone turnover is independent of calories above 250 kcal. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 47:4, pages 318-320.
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Monica H. Wojcik, Erinne Meenaghan, Elizabeth A. Lawson, Madhusmita Misra, Anne Klibanski & Karen K. Miller. (2010) Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa. Bone 46:3, pages 796-800.
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Iris PL Wong, Paul A Baldock & Herbert Herzog. (2010) Gastrointestinal peptides and bone health. Current Opinion in Endocrinology, Diabetes and Obesity 17:1, pages 44-50.
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Lasse Bremholm, Mads Hornum, Ulrik B. Andersen & Jens Juul Holst. (2010) The effect of glucagon-like peptide-2 on arterial blood flow and cardiac parameters. Regulatory Peptides 159:1-3, pages 67-71.
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Dennis B. Henriksen, Peter Alexandersen, Bolette Hartmann, Charlotte L. Adrian, Inger Byrjalsen, Henry G. Bone, Jens J. Holst & Claus Christiansen. (2009) Four-month treatment with GLP-2 significantly increases hip BMD. Bone 45:5, pages 833-842.
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J. S. Walsh & R. Eastell. (2009) Effects of Feeding on Bone Metabolism. Clinical Reviews in Bone and Mineral Metabolism 7:3, pages 230-239.
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Markus Herrmann & Markus Seibel. (2008) The amino- and carboxyterminal cross-linked telopeptides of collagen type I, NTX-I and CTX-I: A comparative review. Clinica Chimica Acta 393:2, pages 57-75.
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Simon P. Robins & Jeffrey D. Brady. 2008. Principles of Bone Biology. Principles of Bone Biology 319 334 .

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