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ORIGINAL ARTICLE

Polymorphism in the promoter region of the NFKB1 gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations

, , , , , , , , & , PhD , MD show all
Pages 1332-1338 | Received 08 Feb 2007, Published online: 08 Jul 2009

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Maryam Alidoust, Asma Khorshid Shamshiri, Amir Tajbakhsh, Seyed Mohammad Gheibihayat, Seyed Mostafa Mazloom, Farzaneh Alizadeh & Alireza Pasdar. (2021) The Significant Role of a Functional Polymorphism in the NF-κB1 Gene in Breast Cancer: Evidence from an Iranian Cohort. Future Oncology 17:35, pages 4895-4905.
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Wenyuan Duan, Erli Wang, Fengquan Zhang, Tongjian Wang, Xiangdong You & Bin Qiao. (2014) Association Between the NFKB1-94ins/del ATTG Polymorphism and Cancer Risk: An Updated Meta-Analysis. Cancer Investigation 32:7, pages 311-320.
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Yan-Feng Zou, Feng-Lai Yuan, Xiao-Liang Feng, Jin-Hui Tao, Ning Ding, Fa-Ming Pan & Fang Wang. (2011) Association Between NFKB1 -94ins/delATTG Promoter Polymorphism and Cancer Risk: A Meta-Analysis. Cancer Investigation 29:1, pages 78-85.
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Articles from other publishers (41)

Faranak Alipourgivi, Aishat Motolani, Alice Y. Qiu, Wenan Qiang, Guang-Yu Yang, Shuibing Chen & Tao Lu. (2023) Genetic Alterations of NF-κB and Its Regulators: A Rich Platform to Advance Colorectal Cancer Diagnosis and Treatment. International Journal of Molecular Sciences 25:1, pages 154.
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Peng Xu, Xianbin Li, Yijun Liang, Zhenshen Bao, Fengyue Zhang, Lili Gu, Saeed Kosari & Wenbin Liu. (2022) PmiRtarbase: A positive miRNA-target regulations database. Computational Biology and Chemistry 98, pages 107690.
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Hanqiang Wu & Jianrong Liang. (2021) Contributions of NFKB1 ‐94insertion/deletion ATTG polymorphism to the susceptibility of gastrointestinal cancers: A meta‐analysis . Journal of Cellular and Molecular Medicine 25:22, pages 10674-10683.
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Lluís Espinosa & Laura Marruecos. (2021) NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer. Biomedicines 9:9, pages 1278.
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Chunwan Lu, John D Klement, Alyssa D Smith, Dafeng Yang, Jennifer L Waller, Darren D Browning, David H Munn & Kebin Liu. (2020) p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy. Journal for ImmunoTherapy of Cancer 8:2, pages e001365.
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Reham El‐hoseny, Mustafa Neamatallah, Moheiddin Alghobary, Adel Zalata, Frank Comhaire & Shimaa M. El‐Beah. (2020) The possible role of NF‐κB1 Rs28362491 polymorphism in male fertility of Egyptian population. Andrologia 52:7.
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Juliana Prado Gonçales, José Valter Joaquim Silva Júnior, Thaísa Regina Rocha Lopes, Tania Regina Tozetto-Mendoza, Deborah de Farias Guimarães, Viviane Martha Santos de Morais & Maria Rosangela Cunha Duarte Coêlho. (2019) Association of polymorphisms in NFκB1 promoter and NFκBIA gene with the development of antibodies against HHV-8 in HIV-infected individuals. Virology 535, pages 255-260.
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Foteinos-Ioannis D. Dimitrakopoulos, Anna G. Antonacopoulou, Anastasia E. Kottorou, Stella Maroussi, Nikolaos Panagopoulos, Ioulia Koukourikou, Chrisoula Scopa, Melpomeni Kalofonou, Angelos Koutras, Thomas Makatsoris, Helen Papadaki, Dimitrios Dougenis, Malcolm Brock & Haralabos P. Kalofonos. (2018) NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival. Scientific Reports 8:1.
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Tine Iskov Kopp, Ulla Vogel, Anne Tjonneland & Vibeke Andersen. (2018) Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study. The American Journal of Clinical Nutrition 107:3, pages 465-479.
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Lorraine A. O’Reilly, Tracy L. Putoczki, Lisa A. Mielke, Jun T. Low, Ann Lin, Adele Preaudet, Marco J. Herold, Kelvin Yaprianto, Lin Tai, Andrew Kueh, Guido Pacini, Richard L. Ferrero, Raffi Gugasyan, Yifang Hu, Michael Christie, Stephen Wilcox, Raelene Grumont, Michael D.W. Griffin, Liam O’Connor, Gordon K. Smyth, Mathias Ernst, Paul Waring, Steve Gerondakis & Andreas Strasser. (2018) Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner. Immunity 48:3, pages 570-583.e8.
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Mohamed Ragab Youssef, Zeinab Ibraheim Attia, Rizk Ahmed El-Baz, Sameh Roshdy & Ahmad Settin. (2017) Genetic polymorphisms of NFκB1-94ins/delATTG and NFκBIA-881A/G genes in Egyptian patients with colorectal cancer. Familial Cancer 16:4, pages 517-524.
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Xiangjun Fu, Jugao Fang, Meng Lian, Qi Zhong, Hongzhi Ma, Ling Feng, Ru Wang & Haizhou Wang. (2017) Identification of microRNAs associated with medullary thyroid carcinoma by bioinformatics analyses. Molecular Medicine Reports 15:6, pages 4266-4272.
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Danielle Fernandes Durso, Maria Giulia Bacalini, Ítalo Faria do Valle, Chiara Pirazzini, Massimiliano Bonafé, Gastone Castellani, Ana Maria Caetano Faria, Claudio Franceschi, Paolo Garagnani & Christine Nardini. (2017) Aberrant methylation patterns in colorectal cancer: a meta-analysis. Oncotarget 8:8, pages 12820-12830.
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Wen Fu, Zhen-Jian Zhuo, Yung-Chang Chen, Jinhong Zhu, Zhang Zhao, Wei Jia, Jin-Hua Hu, Kai Fu, Shi-Bo Zhu, Jing He & Guo-Chang Liu. (2016) NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies . Oncotarget 8:6, pages 9806-9822.
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Duan Wang, Tianhang Xie, Jin Xu, Haoyang Wang, Weinan Zeng, Shuquan Rao, Kai Zhou, Fuxing Pei & Zongke Zhou. (2016) Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies. Scientific Reports 6:1.
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Peiliang Geng, Juanjuan Ou, Jianjun Li, Yunmei Liao, Ning Wang, Rina Sa, Lisha Xiang & Houjie Liang. (2015) Genetic Association Between NFKBIA -881A>G Polymorphism and Cancer Susceptibility. Medicine 94:31, pages e1024.
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Gergely Varga, Gábor Mikala, Hajnalka Andrikovics, Magdalena Koszarska, Katalin Balassa, Emma Ádám, András Kozma, Attila Tordai & Tamás Masszi. (2014) NFKB 1 − 94ins/del ATTG polymorphism is a novel prognostic marker in first line‐treated multiple myeloma . British Journal of Haematology 168:5, pages 679-688.
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Xunli WangHong PengYundan LiangRuifen SunTao WeiZhihui LiYanping GongRixiang GongFeng LiuLin ZhangJingqiang Zhu. (2015) A Functional Insertion/Deletion Polymorphism in the Promoter Region of the NFKB1 Gene Increases the Risk of Papillary Thyroid Carcinoma . Genetic Testing and Molecular Biomarkers 19:3, pages 167-171.
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Tine Iskov Kopp, Vibeke Andersen, Anne Tjonneland & Ulla Vogel. (2015) Polymorphisms in NFKB1 and TLR4 and Interaction with Dietary and Life Style Factors in Relation to Colorectal Cancer in a Danish Prospective Case-Cohort Study. PLOS ONE 10:2, pages e0116394.
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Vibeke Andersen, Tine Kopp, Anne Tjønneland & Ulla Vogel. (2015) No Association between HMOX1 and Risk of Colorectal Cancer and No Interaction with Diet and Lifestyle Factors in a Prospective Danish Case-Cohort Study. International Journal of Molecular Sciences 16:1, pages 1375-1384.
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Vibeke Andersen. (2015) Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology. World Journal of Gastroenterology 21:41, pages 11862.
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Vibeke Andersen & Ulla Vogel. (2014) Interactions between meat intake and genetic variation in relation to colorectal cancer. Genes & Nutrition 10:1.
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Xuewu Nian, Wei Zhang, Limin Li, Yan Sun, Erlin Sun & Ruifa Han. (2014) Meta-analysis of studies on the association between the NF-κB1-94ins/del ATTG promoter polymorphism and cancer. Tumor Biology 35:12, pages 11921-11931.
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Arzuhan Koc, Bahadir Batar, Ozlem Celik, Ilhan Onaran, Ertugrul Tasan & Gonul Kanigur Sultuybek. (2014) Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population. Immunobiology 219:7, pages 531-536.
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Linlin Xu, Shaoyi Huang, Wei Chen, Zhichun Song & Shu Cai. (2014) NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis. Tumor Biology 35:6, pages 5181-5187.
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Xiao Yang, Pengchao Li, Jun Tao, Chao Qin, Qiang Cao, Jinbao Gu, Xiaheng Deng, Jun Wang, Xuzhong Liu, Zijie Wang, Bian Wu, Min Gu, Qiang Lu & Changjun Yin. (2014) Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis . International Journal of Genomics 2014, pages 1-8.
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Mohd Shafi’i Mohd Suzairi, Shing Cheng Tan, Abdul Aziz Ahmad Aizat, Mustapha Mohd Aminudin, Mohd Shahpudin Siti Nurfatimah, Zakaria Dzulkarnaen Andee & Ravindran Ankathil. (2013) The functional −94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer. Cancer Epidemiology 37:5, pages 634-638.
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P. H. Salim, M. Jobim, M. Bredemeier, J. A. B. Chies, J. C. T. Brenol, L. F. Jobim & R. M. Xavier. (2013) Interleukin‐10 Gene Promoter and NFKB 1 Promoter Insertion/Deletion Polymorphisms in Systemic Sclerosis . Scandinavian Journal of Immunology 77:2, pages 162-168.
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V. Andersen, R. Holst & U. Vogel. (2012) Systematic review: diet–gene interactions and the risk of colorectal cancer. Alimentary Pharmacology & Therapeutics 37:4, pages 383-391.
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Hongzhou Cai, Lijiang Sun, Li Cui, Qiang Cao, Chao Qin, Guiming Zhang, Xin Mao, Meilin Wang, Zhengdong Zhang, Pengfei Shao & Changjun Yin. (2013) A Functional Insertion/Deletion Polymorphism (-94 ins/del ATTG) in the Promoter Region of the <b><i>NFKB1</i></b> Gene Is Related to the Risk of Renal Cell Carcinoma. Urologia Internationalis 91:2, pages 206-212.
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Don Vu, Eglis Tellez-Corrales, Prashant Sakharkar, Michael Scott Kissen, Tariq Shah, Ian Hutchinson & David I. Min. (2013) Impact of NF-κB gene polymorphism on allograft outcome in Hispanic renal transplant recipients. Transplant Immunology 28:1, pages 18-23.
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Renquan Lu, Xiang Gao, Yin Chen, Jian Ni, Yongfu Yu, Sheng Li & Lin Guo. (2012) Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population. BMC Gastroenterology 12:1.
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Jonas Ungerbäck, Dimitri Belenki, Aksa Jawad ul-Hassan, Mats Fredrikson, Karin Fransén, Nils Elander, Deepti Verma & Peter Söderkvist. (2012) Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. Carcinogenesis 33:11, pages 2126-2134.
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Yunxian Yu, Hui Liu, Mingjuan Jin, Mingwu Zhang, Yifeng Pan, Shanchun Zhang, Qilong Li & Kun Chen. (2012) The Joint Association of REST and NFKB1 Polymorphisms on the Risk of Colorectal Cancer . Annals of Human Genetics 76:4, pages 269-276.
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Yaxin FanWeijian YuPing YeHuali WangZhongmin WangQingli MengYing DuanXiaohua LiangWanxin An. (2011) NFKB1 Insertion/Deletion Promoter Polymorphism Increases the Risk of Advanced Ovarian Cancer in a Chinese Population . DNA and Cell Biology 30:4, pages 241-245.
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Vibeke Andersen, Jane Christensen, Kim Overvad, Anne Tjønneland & Ulla Vogel. (2010) Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. BMC Cancer 10:1.
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S. Schulz, L. Hierse, W. Altermann, J. Klapproth, U. Zimmermann, Y. Reichert, C. Gläser, A. Kluttig, J. M. Stein, H.-G. Schaller & S. Reichert. (2010) The del/del genotype of the nuclear factor-κB -94ATTG polymorphism and its relation to aggressive periodontitis. Journal of Periodontal Research 45:3, pages 396-403.
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Tielong TangShu CuiXianzhong DengZhiyong GongGuo JiangPingxi WangBo LiaoZhonghai FeiShuyan XianDenang ZengJianyong Li. (2010) Insertion/Deletion Polymorphism in the Promoter Region of NFKB1 Gene Increases Susceptibility for Superficial Bladder Cancer in Chinese . DNA and Cell Biology 29:1, pages 9-12.
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Ellen T. Chang, Brenda M. Birmann, Julie L. Kasperzyk, David V. Conti, Peter Kraft, Richard F. Ambinder, Tongzhang Zheng & Nancy E. Mueller. (2009) Polymorphic Variation in NFKB1 and Other Aspirin-Related Genes and Risk of Hodgkin Lymphoma . Cancer Epidemiology, Biomarkers & Prevention 18:3, pages 976-986.
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Su-Shun Lo, Jen-Hao Chen, Chew-Wun Wu & Win-Yiu Lui. (2009) Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients. Surgery 145:3, pages 280-285.
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Tamas Szamosi, Peter Laszlo Lakatos, Aniko Szilvasi, Laszlo Lakatos, Agota Kovacs, Tamas Molnar, Istvan Altorjay, Maria Papp, Orsolya Szabo, Anna Satori, Zsolt Tulassay, Pal Miheller, Henrik Csaba Horvath, Janos Papp, Attila Tordai & Hajnalka Andrikovics. (2008) The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients. Digestive Diseases and Sciences 54:2, pages 351-359.
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