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ORIGINAL ARTICLE

Autoantibodies in patients with gut motility disorders and enteric neuropathy

, MD, , , , &
Pages 1289-1293 | Received 23 Jan 2007, Published online: 08 Jul 2009

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Shunya Nakane, Akihiro Mukaino, Osamu Higuchi, Mari Watari, Yasuhiro Maeda, Makoto Yamakawa, Keiichi Nakahara, Koutaro Takamatsu, Hidenori Matsuo & Yukio Ando. (2018) Autoimmune autonomic ganglionopathy: an update on diagnosis and treatment. Expert Review of Neurotherapeutics 18:12, pages 953-965.
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Guido Basilisco, Margherita Marchi & Marina Coletta. (2023) Chronic intestinal pseudo‐obstruction in adults: A practical guide to identify patient subgroups that are suitable for more specific treatments. Neurogastroenterology & Motility 36:1.
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Zorisadday Gonzalez, Vincenzo Stanghellini & Roberto De Giorgio. 2023. Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions. Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions 185 204 .
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Beate Niesler, Stefanie Kuerten, I. Ekin Demir & Karl-Herbert Schäfer. (2021) Disorders of the enteric nervous system — a holistic view. Nature Reviews Gastroenterology & Hepatology 18:6, pages 393-410.
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Amy Marie Holland, Ana Carina Bon-Frauches, Daniel Keszthelyi, Veerle Melotte & Werend Boesmans. (2021) The enteric nervous system in gastrointestinal disease etiology. Cellular and Molecular Life Sciences 78:10, pages 4713-4733.
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Shunya Nakane, Masataka Umeda, Shin-ya Kawashiri, Akihiro Mukaino, Kunihiro Ichinose, Osamu Higuchi, Yasuhiro Maeda, Hideki Nakamura, Hidenori Matsuo & Atsushi Kawakami. (2020) Detecting gastrointestinal manifestations in patients with systemic sclerosis using anti-gAChR antibodies. Arthritis Research & Therapy 22:1.
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Jeremy M D Nightingale, Peter Paine, John McLaughlin, Anton Emmanuel, Joanne E Martin & Simon Lal. (2020) The management of adult patients with severe chronic small intestinal dysmotility. Gut 69:12, pages 2074-2092.
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Asami Izu, Taku Homma, Marina Hirabayash, Syun Matsuoka, Toshiyuki Ishige & Hiroyuki Hao. (2020) Idiopathic myenteric ganglionitis as a cause of death in a young male patient with sudden abdominal pain: an autopsy case report. International Journal of Colorectal Disease 35:9, pages 1801-1805.
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Elisa Boschetti, Anna Accarino, Carolina Malagelada, Juan R. Malagelada, Rosanna F. Cogliandro, Alessandra Gori, Vitaliano Tugnoli, Fiorella Giancola, Francesca Bianco, Elena Bonora, Paolo Clavenzani, Umberto Volta, Giacomo Caio, Catia Sternini, Vincenzo Stanghellini, Fernando Azpiroz & Roberto De Giorgio. (2019) Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo‐obstruction. Neurogastroenterology & Motility 31:8.
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Wenjuan Fan, Guijun Fei, Xiaoqing Li, Xiyu Wang, Chaojun Hu, Haiwei Xin, Xiaohong Sun, Yongzhe Li, Jackie D Wood & Xiucai Fang. (2018) Sera with anti‐enteric neuronal antibodies from patients with irritable bowel syndrome promote apoptosis in myenteric neurons of guinea pigs and human SH‐Sy5Y cells. Neurogastroenterology & Motility 30:12.
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Akihiro Mukaino, Hitomi Minami, Hajime Isomoto, Hitomi Hamamoto, Eikichi Ihara, Yasuhiro Maeda, Osamu Higuchi, Tohru Okanishi, Yohei Kokudo, Kazushi Deguchi, Fumisato Sasaki, Toshihito Ueki, Ken-ya Murata, Takeshi Yoshida, Mistuyo Kinjo, Yoshihiro Ogawa, Akio Ido, Hidenori Matsuo, Kazuhiko Nakao & Shunya Nakane. (2018) Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. Journal of Gastroenterology 53:12, pages 1227-1240.
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A. Lütt, K. Michel, D. Krüger, M. S. Volz, M. Nassir, E. Schulz, L. Poralla, P. Tangermann, C. Bojarski, M. Höltje, B. Teegen, W. Stöcker, M. Schemann, B. Siegmund & H. Prüss. (2018) High prevalence and functional effects of serum antineuronal antibodies in patients with gastrointestinal disorders. Neurogastroenterology & Motility 30:6.
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M. Ashat, A. Lewis, H. Liaquat, A. Stocker, L. McElmurray, V. Vedanarayanan, K. Soota, T. Howell, A. Kedar, J. Obert & T. L. Abell. (2017) Intravenous immunoglobulin in drug and device refractory patients with the symptoms of gastroparesis—an open‐label study. Neurogastroenterology & Motility 30:3.
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Jackie D. Wood. (2016) Enteric Nervous System: Neuropathic Gastrointestinal Motility. Digestive Diseases and Sciences 61:7, pages 1803-1816.
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Andrea Maier, Vera Mannartz, Hermann Wasmuth, Christian Trautwein, Ulf-Peter Neumann, Joachim Weis, Joachim Grosse, Matthias Fuest, Max-J. Hilz, Joerg B. Schulz & Christina Haubrich. (2015) GAD Antibodies as Key Link Between Chronic Intestinal Pseudoobstruction, Autonomic Neuropathy, and Limb Stiffness in a Nondiabetic Patient. Medicine 94:31, pages e1265.
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A. C. Ford, N. J. Talley, M. M. Walker & M. P. Jones. (2014) Increased prevalence of autoimmune diseases in functional gastrointestinal disorders: case–control study of 23 471 primary care patients. Alimentary Pharmacology & Therapeutics 40:7, pages 827-834.
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Michael Camilleri & Adil E. Bharucha. 2014. Aminoff's Neurology and General Medicine. Aminoff's Neurology and General Medicine 255 271 .
M. García Carrasco, C. Mendoza Pinto, A. López Colombo, S. Méndez Martínez, R. Andari Sawaya, M. Muñoz Guarneros, L. Vázquez De Lara, M. Lescas Hernández, A. Montiel Jarquín, G. Ramos Álvarez & M. Schmulson. (2013) Irritable bowel syndrome‐type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. Neurogastroenterology & Motility 25:12, pages 958-966.
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P. Paine, J. McLaughlin & S. Lal. (2013) Review article: the assessment and management of chronic severe gastrointestinal dysmotility in adults. Alimentary Pharmacology & Therapeutics 38:10, pages 1209-1229.
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Patrick A Hughes, Heddy Zola, Irmeli A Penttila, Ashley L Blackshaw, Jane M Andrews & Doreen Krumbiegel. (2013) Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?. American Journal of Gastroenterology 108:7, pages 1066-1074.
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Miguel Saps & Ashish Chogle. 2013. Pediatric Neurogastroenterology. Pediatric Neurogastroenterology 247 256 .
A. W. Hubball, B. Lang, M. A. N. Souza, O. D. Curran, J. E. Martin & C. H. Knowles. (2012) Voltage‐gated potassium channel (K v 1) autoantibodies in patients with chagasic gut dysmotility and distribution of K v 1 channels in human enteric neuromusculature (autoantibodies in GI dysmotility) . Neurogastroenterology & Motility 24:8, pages 719.
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Voranush Chongsrisawat. (2012) Anti-enteric Neuronal Antibodies and the Irritable Bowel Syndrome: Are They Really the Accused?. Journal of Neurogastroenterology and Motility 18:2, pages 231-232.
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Jeong Eun Shin. (2012) Dose Irritable Bowel Syndrome and Dysmotility Have an Autoimmune Origin? (Neurogastroenterol Motil 2011;23:1000-1006, e459). Journal of Neurogastroenterology and Motility 18:1, pages 104-105.
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Yosuke Tajima, Tsuneo Iiai, Hitoshi Nogami, Hitoshi Kameyama, Yoshifumi Shimada, Mae Fushiki, Kazuhiko Sekine, Ai Hosoi, Katsuyoshi Hatakeyama & Hajime Umezu. (2012) A Chronic Idiopathic Intestinal Pseudo-obstruction Triggered by Pregnancy. The Japanese Journal of Gastroenterological Surgery 45:3, pages 326-332.
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Angela Vincent, Christian G Bien, Sarosh R Irani & Patrick Waters. (2011) Autoantibodies associated with diseases of the CNS: new developments and future challenges. The Lancet Neurology 10:8, pages 759-772.
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Sean J. Pittock, Vanda A. Lennon, Carissa L. Dege, Nicholas J. Talley & G. Richard LockeIIIIII. (2010) Neural Autoantibody Evaluation in Functional Gastrointestinal Disorders: A Population-Based Case–Control Study. Digestive Diseases and Sciences 56:5, pages 1452-1459.
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Paul E. Hyman. 2011. Pediatric Gastrointestinal and Liver Disease. Pediatric Gastrointestinal and Liver Disease 505 511.e2 .
Chi-Un Pae. (2010) Effect of quetiapine-XR on irritable bowel syndrome. Progress in Neuro-Psychopharmacology and Biological Psychiatry 34:6, pages 1162-1163.
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Hugh J. McMillan & Jayashri Srinivasan. (2010) Achalasia, chronic sensory neuropathy, and N-type calcium channel autoantibodies: beneficial response to IVIG. Clinical Journal of Gastroenterology 3:2, pages 78-82.
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Jutta Keller & Peter Layer. (2009) Intestinal and anorectal motility and functional disorders. Best Practice & Research Clinical Gastroenterology 23:3, pages 407-423.
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Charles H Knowles & Joanne E Martin. (2009) New techniques in the tissue diagnosis of gastrointestinal neuromuscular diseases. World Journal of Gastroenterology 15:2, pages 192.
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Andrew Hubball, Joanne E. Martin, Bethan Lang, Roberto De Giorgio & Charles H. Knowles. (2009) The role of humoral autoimmunity in gastrointestinal neuromuscular diseases. Progress in Neurobiology 87:1, pages 10-20.
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Purna Kashyap & Gianrico Farrugia. (2008) Enteric Autoantibodies and Gut Motility Disorders. Gastroenterology Clinics of North America 37:2, pages 397-410.
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