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Scandinavian Journal of Gastroenterology Volume 42, 2007 - Issue 12
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ORIGINAL ARTICLE

Bile acids induce overexpression of homeobox gene CDX-2 and vascular endothelial growth factor (VEGF) in human Barrett's esophageal mucosa and adenocarcinoma cell line

Grzegorz Burnat First Department of Medicine, University Erlangen-Nuremberg, Germany
,
Tilman Rau Institute of Pathology, University Erlangen-Nuremberg, Germany
,
Esam Elshimi First Department of Medicine, University Erlangen-Nuremberg, Germany
,
Eckhart Georg Hahn First Department of Medicine, University Erlangen-Nuremberg, Germany
&
Prof Peter Christopher Konturek First Department of Medicine, University Erlangen-Nuremberg, GermanyCorrespondence[email protected]
, MD
Pages 1460-1465 | Received 05 Feb 2007, Published online: 08 Jul 2009

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Duochen Jin, Keting Huang, Miao Xu, Hongjin Hua, Feng Ye, Jin Yan, Guoxin Zhang & Yun Wang. (2022) Deoxycholic acid induces gastric intestinal metaplasia by activating STAT3 signaling and disturbing gastric bile acids metabolism and microbiota. Gut Microbes 14:1.
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Nicholas J Clemons, Wayne A Phillips & Reginald V Lord. (2013) Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction. Cancer Biology & Therapy 14:9, pages 782-795.
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Jiaqi Dai, Hongxia Wang, Ying Dong, Yinxin Zhang & Jian Wang. (2013) Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway. Cancer Investigation 31:2, pages 111-120.
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Gen Kusaka, Kaname Uno, Katsunori Iijima, Hiroyuki Endo, Naoki Asano, Tomoyuki Koike, Akira Imatani & Tooru Shimosegawa. (2012) The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus. Scandinavian Journal of Gastroenterology 47:10, pages 1148-1158.
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Iris Tischoff & Andrea Tannapfel. (2008) Barrett’s esophagus: can biomarkers predict progression to malignancy?. Expert Review of Gastroenterology & Hepatology 2:5, pages 653-663.
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Matti Vauhkonen, Hanna Vauhkonen & Pentti Sipponen. (2008) Helicobacter pylori infection induces a reversible expression of the CDX2 transcription factor protein in human gastric epithelium. Scandinavian Journal of Gastroenterology 43:8, pages 915-921.
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Ryosuke Ikeda, Kingo Hirasawa, Yuichiro Ozeki, Atsushi Sawada, Masafumi Nishio, Takehide Fukuchi, Chiko Sato & Shin Maeda. (2022) Cervical esophageal adenocarcinoma of intestinal type in ectopic gastric mucosa. DEN Open 3:1.
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Xueli Song, Yaping An, Danfeng Chen, Wanru Zhang, Xuemei Wu, Chuqiao Li, Sinan Wang, Wenxiao Dong, Bangmao Wang, Tianyu Liu, Weilong Zhong, Tao Sun & Hailong Cao. (2021) Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis. Cancer Science 113:2, pages 459-477.
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Monika Vyas, Romulo Celli, Manpreet Singh, Natalie Patel, Harry R. Aslanian, Daniel Boffa, Yanhong Deng, Maria M. Ciarleglio, Loren Laine & Dhanpat Jain. (2020) Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. Human Pathology 105, pages 67-73.
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Shayan Khalafi, Albert Craig Lockhart, Alan S. Livingstone & Wael El-Rifai. (2020) Targeted Molecular Therapies in the Treatment of Esophageal Adenocarcinoma, Are We There Yet?. Cancers 12:11, pages 3077.
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A. R. Reyzis. (2019) Ursodeoxycholic acid and cancer prevention. Medical Council:14, pages 39-43.
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Ken‐ichi Mukaisho, Shunpei Kanai, Ryoji Kushima, Takahisa Nakayama, Takanori Hattori & Hiroyuki Sugihara. (2019) Barretts's carcinogenesis. Pathology International 69:6, pages 319-330.
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Aleksandra M. Urbanska, Selvarangan Ponnazhagan & Masoud Mozafari. (2018) Pathology, Chemoprevention, and Preclinical Models for Target Validation in Barrett Esophagus. Cancer Research 78:14, pages 3747-3754.
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Reilly J. Clark, Michael P. Craig, Sangeeta Agrawal & Madhavi Kadakia. (2018) microRNA involvement in the onset and progression of Barrett's esophagus: a systematic review. Oncotarget 9:8, pages 8179-8196.
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Yun-Cang Wang, Zhi-Qiang Wang, Yong Yuan, Tao Ren, Peng-Zhi Ni & Long-Qi Chen. (2018) Notch Signaling Pathway Is Inhibited in the Development of Barrett’s Esophagus: An In Vivo and In Vitro Study. Canadian Journal of Gastroenterology and Hepatology 2018, pages 1-11.
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Mafalda Trippel, Sara Imboden, Andrea Papadia, Michael D. Mueller, Nando Mertineit, Kirsi Härmä, Alina Nicolae, Erik Vassella & Tilman T. Rau. (2017) Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report. Diagnostic Pathology 12:1.
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Christian Kascholke, Tina Loth, Caroline Kohn-Polster, Stephanie Möller, Peter Bellstedt, Michaela Schulz-Siegmund, Matthias Schnabelrauch & Michael C. Hacker. (2017) Dual-Functional Hydrazide-Reactive and Anhydride-Containing Oligomeric Hydrogel Building Blocks. Biomacromolecules 18:3, pages 683-694.
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T. Rau. (2016) Pathogenetische Aspekte bei Vorläuferläsionen gastrointestinaler TumorenPathogenetic aspects in precursor lesions of gastrointestinal tumors. Der Pathologe 37:S2, pages 186-190.
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Gen Kusaka. (2016) Role of nitric oxide in the pathogenesis of Barrett’s-associated carcinogenesis. World Journal of Gastrointestinal Pathophysiology 7:1, pages 131.
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Tina Samuels, Craig Hoekzema, Jon Gould, Matthew Goldblatt, Matthew Frelich, Matthew Bosler, Sang-Hyuk Lee & Nikki Johnston. (2015) Local Synthesis of Pepsin in Barrett’s Esophagus and the Role of Pepsin in Esophageal Adenocarcinoma. Annals of Otology, Rhinology & Laryngology 124:11, pages 893-902.
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Jing Shan, Tadayuki OshimaRicard Farre, Hirokazu FukuiJiro WatariHiroto Miwa. (2014) IL-4 induces columnar-like differentiation of esophageal squamous epithelium through JAK/PI3K pathway: possible role in pathogenesis of Barrett's esophagus. American Journal of Physiology-Gastrointestinal and Liver Physiology 306:8, pages G641-G649.
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Sho Sato, Hiroto Yamamoto, Ken-ichi Mukaisho, Shota Saito, Takanori Hattori, Gaku Yamamoto & Hiroyuki Sugihara. (2014) Continuous Taurocholic Acid Exposure Promotes Esophageal Squamous Cell Carcinoma Progression Due to Reduced Cell Loss Resulting from Enhanced Vascular Development. PLoS ONE 9:2, pages e88831.
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Chadrick E. Denlinger & Robert K. Thompson. (2012) Molecular Basis of Esophageal Cancer Development and Progression. Surgical Clinics of North America 92:5, pages 1089-1103.
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Tilman T. Rau, Anja Rogler, Myrjam Frischauf, Andreas Jung, Peter C. Konturek, Arno Dimmler, Gerhard Faller, Bettina Sehnert, Wael El-Rifai, Arndt Hartmann, Reinhard E. Voll & Regine Schneider-Stock. (2012) Methylation-Dependent Activation of CDX1 through NF-κB. The American Journal of Pathology 181:2, pages 487-498.
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P. Bus, P. D. Siersema & J. W. P. M. van Baal. (2012) Cell culture models for studying the development of Barrett’s esophagus: a systematic review. Cellular Oncology 35:3, pages 149-161.
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Elke PradeMoritz TobiaschIvana HitkovaIsabell SchäfferFan LianXiangbin XingMarc TänzerSandra RauserAxel WalchMarcus FeithStefan PostChristoph Röcken, Roland M. SchmidMatthias P.A. EbertElke Burgermeister. (2012) Bile Acids Down-Regulate Caveolin-1 in Esophageal Epithelial Cells through Sterol Responsive Element-Binding Protein. Molecular Endocrinology 26:5, pages 819-832.
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Ben Selvan, Anup Ramachandran, Anu Korula, G. Jayakumar Amirtharaj, Kavithapriya Kettimuthu, Sheila Nair, Aravindan Nair, Prasanna Samuel & George Mathew. (2012) Low dose aspirin prevents duodenoesophageal reflux induced mucosal changes in wistar rat esophagus by MAP kinase mediated pathways. International Journal of Surgery 10:2, pages 73-79.
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Jiaqi Dai, Hongxia Wang, Yihui Shi, Ying Dong, Yinxin Zhang & Jian Wang. (2011) Impact of bile acids on the growth of human cholangiocarcinoma via FXR. Journal of Hematology & Oncology 4:1.
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K. R. McQuaid, L. Laine, M. B. Fennerty, R. Souza & S. J. Spechler. (2011) Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. Alimentary Pharmacology & Therapeutics 34:2, pages 146-165.
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Wayne A Phillips, Reginald V Lord, Derek J Nancarrow, David I Watson & David C Whiteman. (2011) Barrett's esophagus. Journal of Gastroenterology and Hepatology 26:4, pages 639-648.
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David H. Wang & Rhonda F. Souza. (2011) Biology of Barrett's Esophagus and Esophageal Adenocarcinoma. Gastrointestinal Endoscopy Clinics of North America 21:1, pages 25-38.
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Kaushik Mukherjee, A. Bapsi Chakravarthy, Laura W. Goff & Wael El-Rifai. (2010) Esophageal Adenocarcinoma: Treatment Modalities in the Era of Targeted Therapy. Digestive Diseases and Sciences 55:12, pages 3304-3314.
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Mawash Babar, Darren Ennis, Mohamed Abdel-Latif, Patrick J. Byrne, Narayanasamy Ravi & John V. Reynolds. (2010) Differential molecular changes in patients with asymptomatic long-segment Barrett's esophagus treated by antireflux surgery or medical therapy. The American Journal of Surgery 199:2, pages 137-143.
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Nelly E. Avissar, Liana Toia, Yingchuan Hu, Thomas J. Watson, Carolyn Jones, Daniel P. Raymond, Alexi Matousek & Jeffrey H. Peters. (2009) Bile Acid Alone, or in Combination with Acid, Induces CDX2 Expression Through Activation of the Epidermal Growth Factor Receptor (EGFR). Journal of Gastrointestinal Surgery 13:2, pages 212-222.
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Andrea H. Devlin, Marie McIlroy, Hayley D. McKeen, Pramode Bonde, A.A. Carlos Menezes, Christine J. Swarbrick, Tracy Robson, David G. Hirst, F. Charles Campbell, James A. McGuigan & Stephanie R. McKeown. (2008) Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux. Molecular Carcinogenesis 48:2, pages 110-117.
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