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Scandinavian Journal of Infectious Diseases Volume 34, 2002 - Issue 12
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Research Article

Single- and Multiple-dose Pharmacokinetics of Oral Moxifloxacin and Clarithromycin, and Concentrations in Serum, Saliva and Faeces

Olaf Burkhardt
,
Klaus Borner
,
Heino Staß
,
Gerrit Beyer
,
Markus Allewelt
,
Carl Erik Nord
&
Hartmut Lode
 show all
Pages 898-903 | Published online: 08 Jul 2009

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Olaf Burkhardt & Tobias Welte. (2009) 10 years’ experience with the pneumococcal quinolone moxifloxacin. Expert Review of Anti-infective Therapy 7:6, pages 645-668.
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David RP Guay. (2006) Moxifloxacin in the treatment of skin and skin structure infections. Therapeutics and Clinical Risk Management 2:4, pages 417-434.
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Olaf Burkhardt, Hartmut Derendorf, Doris Jäger, Vipul Kumar, Rajanikanth Madabushi, Klaus Röhl & Jürgen Barth. (2006) Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis. Scandinavian Journal of Infectious Diseases 38:10, pages 904-908.
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Articles from other publishers (33)

Lina Davies Forsman, Hannah Yejin Kim, Thi Anh Nguyen & Jan-Willem C. Alffenaar. (2024) Salivary Therapeutic Drug Monitoring of Antimicrobial Therapy: Feasible or Futile?. Clinical Pharmacokinetics 63:3, pages 269-278.
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Andrew Burke, Daniel Smith, Chris Coulter, Scott C. Bell, Rachel Thomson & Jason A. Roberts. (2021) Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Drug Treatment of Non-Tuberculous Mycobacteria in Cystic Fibrosis. Clinical Pharmacokinetics 60:9, pages 1081-1102.
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Ramesh Boinpally, Brian McNamee, Li Yao, Matthew Butler, Danielle McGeeney, Lisa Borbridge & Antonia Periclou. (2021) A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single‐Dose, Phase 1 Crossover Trial. Clinical Pharmacology in Drug Development 10:9, pages 1099-1107.
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Svetlana N. Kondratenko, Irina V. Zolkina & Eugenia V. Shikh. (2020) A study of the pharmacokinetics of moxifloxacin by the dynamics of its distribution in the blood plasma and saliva of healthy volunteers: a comparative analysis and possible extrapolation methods. Drug Metabolism and Drug Interactions 35:4.
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Abhijeet Jakate, Ramesh Boinpally, Matthew Butler, Kaifeng Lu, Danielle McGeeney & Antonia Periclou. (2019) Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial. Clinical Pharmacology & Therapeutics 107:4, pages 1014-1022.
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Simone H. J. van den ElsenLisette M. OostenbrinkScott K. HeysellDaiki Hira, Daan J. TouwOnno W. AkkermanMathieu S. BolhuisJan-Willem C. Alffenaar. (2018) Systematic Review of Salivary Versus Blood Concentrations of Antituberculosis Drugs and Their Potential for Salivary Therapeutic Drug Monitoring. Therapeutic Drug Monitoring 40:1, pages 17-37.
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Charles Burdet, Sakina Sayah-Jeanne, Thu Thuy Nguyen, Christine Miossec, Nathalie Saint-Lu, Mark Pulse, William Weiss, Antoine Andremont, France Mentré & Jean de Gunzburg. (2017) Protection of Hamsters from Mortality by Reducing Fecal Moxifloxacin Concentration with DAV131A in a Model of Moxifloxacin-Induced Clostridium difficile Colitis. Antimicrobial Agents and Chemotherapy 61:10.
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Tony K. L. Kiang & Mary H. H. Ensom. (2015) A Qualitative Review on the Pharmacokinetics of Antibiotics in Saliva: Implications on Clinical Pharmacokinetic Monitoring in Humans. Clinical Pharmacokinetics 55:3, pages 313-358.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 1129 1134 .
Simon Baines & Mark Wilcox. (2015) Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C. difficile Infection. Antibiotics 4:3, pages 267-298.
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Danny Tsai, Janattul-Ain Jamal, Joshua S. Davis, Jeffrey Lipman & Jason A. Roberts. (2014) Interethnic Differences in Pharmacokinetics of Antibacterials. Clinical Pharmacokinetics 54:3, pages 243-260.
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Elisa Chilet-RosellMa Teresa Ruiz-CanteroMa Angeles Pardo. (2014) Gender Analysis of Moxifloxacin Clinical Trials. Journal of Women's Health 23:1, pages 77-104.
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M. S. Bolhuis, R. van Altena, K. van Hateren, W. C. M. de Lange, B. Greijdanus, D. R. A. Uges, J. G. W. Kosterink, T. S. van der Werf & J. W. C. Alffenaar. (2013) Clinical Validation of the Analysis of Linezolid and Clarithromycin in Oral Fluid of Patients with Multidrug-Resistant Tuberculosis. Antimicrobial Agents and Chemotherapy 57:8, pages 3676-3680.
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Miranda W. Langendam, Edine W. Tiemersma, Marieke J. van der Werf & Andreas Sandgren. (2013) Adverse Events in Healthy Individuals and MDR-TB Contacts Treated with Anti-Tuberculosis Drugs Potentially Effective for Preventing Development of MDR-TB: A Systematic Review. PLoS ONE 8:1, pages e53599.
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Gregory Venetis, Kalliopi Chatzika, Georgia Pitsiou, Nikolaos Kechagias, Kostas Antoniades & Ioannis P. Kioumis. (2012) Saliva and Blood Concentration of Cefuroxime in Patients Undergoing Maxillofacial Surgery. Journal of Oral and Maxillofacial Surgery 70:6, pages 1398-1403.
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A. K. Hemanth Kumar, V. Sudha, R. Srinivasan & Geetha Ramachandran. (2011) Simple and rapid liquid chromatography method for determination of moxifloxacin in saliva. Journal of Chromatography B 879:30, pages 3663-3667.
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Ala F. Nassar. 2010. Biotransformation and Metabolite Elucidation of Xenobiotics. Biotransformation and Metabolite Elucidation of Xenobiotics 163 216 .
J. W. C. Alffenaar, W. A. Nienhuis, F. de Velde, A. T. Zuur, A. M. A. Wessels, D. Almeida, J. Grosset, O. Adjei, D. R. A. Uges & T. S. van der Werf. (2010) Pharmacokinetics of Rifampin and Clarithromycin in Patients Treated for Mycobacterium ulcerans Infection . Antimicrobial Agents and Chemotherapy 54:9, pages 3878-3883.
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Ala F. Nassar. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 13 .
M. C. Ober, T. Hoppe-Tichy, J. Koninger, O. Schunter, H.-G. Sonntag, M. A. Weigand, J. Encke, C. Gutt & S. Swoboda. (2009) Tissue penetration of moxifloxacin into human gallbladder wall in patients with biliary tract infections. Journal of Antimicrobial Chemotherapy 64:5, pages 1091-1095.
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Ala F. Nassar. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 269 281 .
Markus Zeitlinger, Claudia Christina Wagner & Birgit Heinisch. (2009) Ketolides – The Modern Relatives of Macrolides. Clinical Pharmacokinetics 48:1, pages 23-38.
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Lambrini Galani, Angelos Pefanis, Vissaria Sakka, Dimitrios Iliopoulos, Ismini Donta, Helen Triantafyllidi, Ioannis Skiadas, Panayiotis Karayiannakos & Helen Giamarellou. (2009) Successful treatment with moxifloxacin of experimental aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA). International Journal of Antimicrobial Agents 33:1, pages 65-69.
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Friederike Traunmüller, Markus Zeitlinger, Petra Zeleny, Markus Müller & Christian Joukhadar. (2007) Pharmacokinetics of Single- and Multiple-Dose Oral Clarithromycin in Soft Tissues Determined by Microdialysis. Antimicrobial Agents and Chemotherapy 51:9, pages 3185-3189.
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David RP Guay. (2006) Moxifloxacin in the treatment of skin and skin structure infections. Therapeutics and Clinical Risk Management 2:4, pages 417-434.
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Elia Sirvent, Montserrat Ruiz, Juan C. Rodríguez & Gloria Royo. (2006) Estudio de la actividad comparada de varias fluoroquinolonas frente a Pseudomonas aeruginosa mediante la determinación de la concentración preventiva de mutantes. Enfermedades Infecciosas y Microbiología Clínica 24:10, pages 603-607.
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Federico Pea, Federica Pavan, Emilio Lugatti, Flavio Dolcet, Giovanni Talmassons, Maria Consuelo Screm & Mario Furlanut. (2006) Pharmacokinetic and Pharmacodynamic Aspects of Oral Moxifloxacin 400 mg/day in Elderly Patients with Acute Exacerbation of Chronic Bronchitis. Clinical Pharmacokinetics 45:3, pages 287-295.
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. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 2392 2395 .
Johan K.M. Aps & Luc C. Martens. (2005) Review: The physiology of saliva and transfer of drugs into saliva. Forensic Science International 150:2-3, pages 119-131.
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Olaf Burkhardt, Heino Stass, Uwe Thuss, Klaus Borner & Tobias Welte. (2005) Effects of Enteral Feeding on the Oral Bioavailability of Moxifloxacin in Healthy Volunteers. Clinical Pharmacokinetics 44:9, pages 969-976.
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Chiu-Yeung Chan, Carrie Au-Yeang, Wing-Wai Yew, Chi-Chiu Leung & Augustine F. B. Cheng. (2004) In Vitro Postantibiotic Effects of Rifapentine, Isoniazid, and Moxifloxacin against Mycobacterium tuberculosis . Antimicrobial Agents and Chemotherapy 48:1, pages 340-343.
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