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Original Article

Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients

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Pages 59-62 | Received 05 Feb 2007, Published online: 08 Jul 2009

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Ann-Brit E Hansen, Hanne T Vestergaard, Ram B Dessau, Jacob Bodilsen, Nanna S Andersen, Lars H Omland, Claus B Christiansen, Svend Ellermann-Eriksen, Lene Nielsen, Thomas Benfield, Henrik T Sørensen, Christian Ø Andersen, Anne-Mette Lebech & Niels Obel. (2020) Long-Term Survival, Morbidity, Social Functioning and Risk of Disability in Patients with a Herpes Simplex Virus Type 1 or Type 2 Central Nervous System Infection, Denmark, 2000–2016. Clinical Epidemiology 12, pages 745-755.
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Jesper Damsgaard, Simon Hjerrild, Henning Andersen & Peter Derek Christian Leutscher. (2015) Long-term neuropsychiatric consequences of aseptic meningitis in adult patients. Infectious Diseases 47:6, pages 357-363.
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Ahmad K Abou-Foul, Thajunisha M Buhary & Sedki L Gayed. (2014) Herpes simplex virus type 2-associated recurrent aseptic (Mollaret’s) meningitis in genitourinary medicine clinic: a case report. International Medical Case Reports Journal 7, pages 31-33.
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Articles from other publishers (28)

Isabella L. Platz, Malte M. Tetens, Ram Dessau, Svend Ellermann-Eriksen, Nanna S. Andersen, Veronika Vorobieva Solholm Jensen, Christian Østergaard, Jacob Bodilsen, Kirstine Kobberøe Søgaard, Jette Bangsborg, Alex Christian Yde Nielsen, Jens Kjølseth Møller, Anne-Mette Lebech, Lars Haukali Omland & Niels Obel. (2024) Characteristics and long-term prognosis of Danish residents with a positive intrathecal antibody index test for herpes simplex virus or varicella-zoster virus compared with individuals with a positive cerebrospinal fluid PCR: a nationwide cohort study. Clinical Microbiology and Infection 30:2, pages 240-246.
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Buket BADDAL, Aysegul BOSTANCI & Kaya SÜER. (2023) HSV-2 Associated Meningitis Case: A Challenging Diagnosis in An Immunocompetent Woman. Journal of Emergency Medicine Case Reports 14:3, pages 60-62.
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Pelle Trier Petersen, Jacob Bodilsen, Micha Phill Grønholm Jepsen, Lykke Larsen, Merete Storgaard, Birgitte Rønde Hansen, Jannik Helweg-Larsen, Lothar Wiese, Hans Rudolf Lüttichau, Christian Østergaard Andersen, Henrik Nielsen & Christian Thomas Brandt. (2023) Clinical features and prognostic factors in adults with viral meningitis. Brain 146:9, pages 3816-3825.
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Aurélie Truffot, Johan Noble, Anaïs Dartevel, Eloi Chevalier, Celine Dard, Diane Giovannini, Julien Andreani, Sonia Burrel, David Boutolleau, Olivier Epaulard, Patricia Pavese, Patrice Morand, Julien Lupo & Raphaële Germi. (2023) Fatal HSV-2 primary infection most likely acquired by kidney transplantation: A case report. International Journal of Antimicrobial Agents 61:5, pages 106769.
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Jacob Bodilsen, Pierre Tattevin, Steven Y C Tong, Pontus Naucler & Henrik Nielsen. (2022) Treatment of Herpes Simplex Virus Type 2 Meningitis: A Survey Among Infectious Diseases Specialists in France, Sweden, Australia, and Denmark. Open Forum Infectious Diseases 9:12.
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Xin Li, Jing Li, Yawei Shi, Guode Wu, Manxia Wang, Ye Zhang & Han Xia. (2022) Application of metagenomic next-generation sequencing technique for diagnosing a specific case of necrotizing meningoencephalitis caused by human herpesvirus 2. Open Life Sciences 17:1, pages 1217-1222.
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Anna Jakobsen, Marie Thaarup Skov, Lykke Larsen, Pelle Trier Petersen, Christian Brandt, Lothar Wiese, Birgitte Rønde Hansen, Hans Rudolf Lüttichau, Malte Mose Tetens, Jannik Helweg-Larsen, Merete Storgaard, Henrik Nielsen & Jacob Bodilsen. (2022) Herpes Simplex Virus 2 Meningitis in Adults: A Prospective, Nationwide, Population-Based Cohort Study. Clinical Infectious Diseases 75:5, pages 753-760.
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Marie Thérèse Ngo Nsoga, Alice Accorroni, Aline Mamin & Manuel Schibler. (2022) Primary HSV-2 Infection Complicated by Radiculomyelitis in a Young Immunocompetent Female Patient with Inherited Chromosomally Integrated HHV-6: A Case Report. Viruses 14:9, pages 1979.
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A. Jouffroy, F. Desrousseaux, A. Juret, A. Mohebi & M. Harboun. (2018) Une méningo-encéphalite herpétique à Herpès Simplex Virus de type 2 chez une patiente de 91 ans. NPG Neurologie - Psychiatrie - Gériatrie 18:107, pages 309-313.
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Julien Lupo, Ophélie Dos Santos, Raphaele Germi, Monique Baccard-Longère, Jean-Paul Stahl, Olivier Epaulard & Patrice Morand. (2016) Herpes Simplex Type 2 Encephalitis and Methotrexate Medication: A Fortuitous or Causative Association in a Patient with Spondyloarthritis?. Antiviral Therapy 22:4, pages 357-359.
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Ronald G. Hauser, Sheldon M. Campbell, Cynthia A. Brandt & Shiyi Wang. (2017) Cost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing. Journal of Clinical Microbiology 55:5, pages 1566-1575.
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Fiona McGill, Michael J. Griffiths & Tom Solomon. (2017) Viral meningitis: current issues in diagnosis and treatment. Current Opinion in Infectious Diseases 30:2, pages 248-256.
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J. Reina, M. Leyes & C. Taboada. (2016) Meningitis linfocitarias causadas por el virus herpes simple tipo 2. Revista Clínica Española 216:5, pages 290-291.
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Quanhathai Kaewpoowat, Lucrecia Salazar, Elizabeth Aguilera, Susan H. Wootton & Rodrigo Hasbun. (2015) Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes. Infection 44:3, pages 337-345.
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MP. Fernandez-Gerlinger, S. Greffe, A. Meffre, J. Grenet, S. Au, M. Bojanova, E. Rouveix & F. Rozenberg. (2015) HSV-2 meningoencephalitis in an immunocompetent young man: what is the pathogenesis and what is the treatment?. Journal of Clinical Virology 69, pages 40-43.
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Seilesh Kadambari, Ifeanyichukwu Okike, Sonia Ribeiro, Mary E. Ramsay, Paul T. Heath, Mike Sharland & Shamez N. Ladhani. (2014) Seven-fold increase in viral meningo-encephalitis reports in England and Wales during 2004–2013. Journal of Infection 69:4, pages 326-332.
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Song Mi Moon, Tark Kim, Eun Mi Lee, Joong Koo Kang, Sang-Ahm Lee & Sang-Ho Choi. (2014) Comparison of clinical manifestations, outcomes and cerebrospinal fluid findings between herpes simplex type 1 and type 2 central nervous system infections in adults. Journal of Medical Virology 86:10, pages 1766-1771.
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Farrah J. Mateen, Stephanie A. Miller & Allen J. AksamitJr.Jr.. (2014) Herpes Simplex Virus 2 Encephalitis in Adults. Mayo Clinic Proceedings 89:2, pages 274-275.
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Kevin R. Barker, Robert Sarafino-Wani, Aysha Khanom, Paul D. Griffiths, Michael G. Jacobs & Daniel P. Webster. (2014) Encephalitis in an immunocompetent man. Journal of Clinical Virology 59:1, pages 1-3.
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Rebecca W. Widener & Richard J. Whitley. 2014. Neurovirology. Neurovirology 251 263 .
Stephanie Miller, Farrah J. Mateen & Allen J. AksamitJr.Jr.. (2013) Herpes simplex virus 2 meningitis: a retrospective cohort study. Journal of NeuroVirology 19:2, pages 166-171.
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Theresa L. Geurs, Elaise B. Hill, Danna M. Lippold & Anthony R. French. (2012) Sex differences in murine susceptibility to systemic viral infections. Journal of Autoimmunity 38:2-3, pages J245-J253.
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Imen Nahdi, Hanen Boukoum, Abid Nabil Ben Salem, Fouad Ben Romdane, Saber Hammami, Saber Chebel, Frih‐Ayed Mahbouba, Mohamed Neji Guediche, Mohamed Chakroun, Mahjoub Aouni, Berthe‐Marie Imbert‐Marcille & Celine Bressollette‐Bodin. (2011) Detection of herpes simplex virus (1 and 2), varicella‐zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent tunisian patients with acute neuromeningeal disorder. Journal of Medical Virology 84:2, pages 282-289.
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S. Berroir & C. Henry. (2011) Encéphalite herpétique due au virus herpès simplex de type 2. Pratique Neurologique - FMC 2:4, pages 264-267.
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Jin-Mei Li, Ding Lei, Fang Peng, Yi-Jun Zeng, Liang Li, Zeng-Liang Xia, Xiao-Qiang Xia & Dong Zhou. (2011) Detection of human herpes virus 6B in patients with mesial temporal lobe epilepsy in West China and the possible association with elevated NF-κB expression. Epilepsy Research 94:1-2, pages 1-9.
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Marie L. Landry, Jennifer Greenwold & Holenarasipur R. Vikram. (2009) Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy. The American Journal of Medicine 122:7, pages 688-691.
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Johann Sellner, Roberto Buonomano, Krassen Nedeltchev, Oliver Findling, Gerhard Schroth, Daniel V Surbek & Stephen L Leib. (2009) A case of maternal herpes simplex virus encephalitis during late pregnancy. Nature Clinical Practice Neurology 5:1, pages 51-56.
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P. P. Urban, W. Jöhnck, C. Pohlmann, S. Marrakchi & R. Brüning. (2008) Reversible progressive cognitive decline due to herpes simplex type 2 encephalitis with normal MR imaging. Journal of Neurology 255:12, pages 1975-1977.
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