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Original Article

Severe sepsis in autologous stem cell transplant recipients: Microbiological aetiology, risk factors and outcome

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Pages 14-20 | Received 03 Sep 2008, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Viggo Holten Mortensen, Mette Søgaard, Brian Kristensen, Lone Hagens Mygind & Henrik Carl Schønheyder. (2022) Risk factors for hospital-acquired bacteraemia – an explorative case–control study of hospital interventions. Infectious Diseases 54:3, pages 178-185.
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Stefan Becker, Sini Korpelainen, Miika Arvonen, Sari Hämäläinen, Esa Jantunen, Marika Lappalainen, Kari Pulkki, Pekka Riikonen & Auni Juutilainen. (2019) MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia. Leukemia & Lymphoma 60:12, pages 3036-3043.
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Rosa Rönkkö, Auni Juutilainen, Irma Koivula, Matti Vänskä, Tapio Nousiainen, Esa Jantunen & Sari Hämäläinen. (2018) Changes in the microbiological epidemiology of febrile neutropenia in autologous stem cell transplant recipients. Infectious Diseases 50:6, pages 436-442.
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Aarne Kolonen, Marjatta Sinisalo, Reetta Huttunen, Jaana Syrjänen, Janne Aittoniemi, Heini Huhtala, Marja Sankelo, Hannele Rintala, Riikka Räty, Esa Jantunen, Tapio Nousiainen, Marjaana Säily, Marjut Kauppila, Maija Itälä-Remes, Hanna Ollikainen, Auvo Rauhala, Pirjo Koistinen & Erkki Elonen. (2017) Bloodstream infections in acute myeloid leukemia patients treated according to the Finnish Leukemia Group AML-2003 protocol – a prospective nationwide study. Infectious Diseases 49:11-12, pages 799-808.
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Marika Lappalainen, Sari Hämäläinen, Auni Juutilainen, Irma Koivula, Kari Pulkki & Esa Jantunen. (2017) Asymmetric dimethylarginine in the assessment of febrile neutropenia in hematological patients. Scandinavian Journal of Clinical and Laboratory Investigation 77:2, pages 130-134.
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Heather Landau, Kevin Wood, David J. Chung, Guenther Koehne, Nikoletta Lendvai, Hani Hassoun, Alexander Lesokhin, Elizabeth Hoover, Junting Zheng, Sean M. Devlin & Sergio Giralt. (2016) Fractionated stem cell infusions for patients with plasma cell myeloma undergoing autologous hematopoietic cell transplantation. Leukemia & Lymphoma 57:8, pages 1781-1785.
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Auni Juutilainen, Sari Hämäläinen, Kari Pulkki, Taru Kuittinen, Tapio Nousiainen, Esa Jantunen & Irma Koivula. (2011) Biomarkers for bacteremia and severe sepsis in hematological patients with neutropenic fever: multivariate logistic regression analysis and factor analysis. Leukemia & Lymphoma 52:12, pages 2349-2355.
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Sari Hämäläinen, Auni Juutilainen, Taru Kuittinen, Tapio Nousiainen, Irma Matinlauri, Kari Pulkki, Irma Koivula & Esa Jantunen. (2010) Serum amino-terminal pro-brain natriuretic peptide in hematological patients with neutropenic fever: a prospective comparison with C-reactive protein. Leukemia & Lymphoma 51:6, pages 1040-1046.
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Auni Juutilainen, Sari Hämäläinen, Irma Matinlauri, Taru Kuittinen, Tapio Nousiainen, Kari Pulkki, Irma Koivula & Esa Jantunen. (2010) Serial plasma lactate measurements in haematological patients with neutropenic fever. Scandinavian Journal of Infectious Diseases 42:2, pages 102-108.
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Nozomu Yoshino, Shun-ichi Kimura, Akari Matsuoka, Tomohiro Meno, Takuto Ishikawa, Yuhei Nakamura, Masakatsu Kawamura, Junko Takeshita, Shunto Kawamura, Yukiko Misaki, Kazuki Yoshimura, Ayumi Gomyo, Yosuke Okada, Masaharu Tamaki, Yu Akahoshi, Machiko Kusuda, Kazuaki Kameda, Aki Tanihara, Hidenori Wada, Hideki Nakasone, Shinichi Kako & Yoshinobu Kanda. (2023) Clinical features of febrile neutropenia and bloodstream infection in autologous hematopoietic cell transplantation: Comparison to those in intensive chemotherapy for acute myeloid leukemia. Journal of Infection and Chemotherapy 29:4, pages 384-390.
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Çiğdem EROL, Nuran SARI, Şahika Zeynep AKI & Esin ŞENOL. (2021) The frequency, epidemiology and risk factors of bloodstream infections in febrile neutropenic patients with hematologic malignanciesFebril nötropenik hastalarda bakteriyemi sıklığı, risk faktörleri ve epidemiyolojisi. Turkish Journal of Clinics and Laboratory 12:4, pages 438-445.
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Margaret L. Lind, Stephen J. Mooney, Marco Carone, Benjamin M. Althouse, Catherine Liu, Laura E. Evans, Kevin Patel, Phuong T. Vo, Steven A. Pergam & Amanda I. Phipps. (2021) Development and Validation of a Machine Learning Model to Estimate Bacterial Sepsis Among Immunocompromised Recipients of Stem Cell Transplant. JAMA Network Open 4:4, pages e214514.
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Meera Mohan, Sandra Susanibar‐Adaniya, Amy Buros, Juan Carlos Rico Crescencio, Mary J. Burgess, Katherine Lusardi, Faith Davies, Gareth Morgan, Frits Vanrhee, Maurizio Zangari, Carolina Schinke, Sharmilan Thanendrarajan & Atul Kothari. (2019) Bacteremias following autologous stem cell transplantation for multiple myeloma: Risk factors and outcomes. Transplant Infectious Disease 21:2, pages e13052.
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Carina Intke, Sini Korpelainen, Sari Hämäläinen, Matti Vänskä, Irma Koivula, Esa Jantunen, Kari Pulkki & Auni Juutilainen. (2018) Interleukin-1 receptor antagonist as a biomarker of sepsis in neutropenic haematological patients. European Journal of Haematology 101:5, pages 691-698.
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Ching-Hsun Wang, Feng-Yee Chang, Tsu-Yi Chao, Woei-Yau Kao, Ching-Liang Ho, Yeu-Chin Chen, Ming-Shen Dai, Ping-Ying Chang, Yi-Ying Wu & Jung-Chung Lin. (2018) Characteristics comparisons of bacteremia in allogeneic and autologous hematopoietic stem cell-transplant recipients with levofloxacin prophylaxis and influence on resistant bacteria emergence. Journal of Microbiology, Immunology and Infection 51:1, pages 123-131.
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Mindy G. Schuster, Angela A. Cleveland, Erik R. Dubberke, Carol A. Kauffman, Robin K. Avery, Shahid Husain, David L. Paterson, Fernanda P. Silveira, Tom M. Chiller, Kaitlin Benedict, Kathleen Murphy & Peter G. Pappas. (2017) Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study. Open Forum Infectious Diseases 4:2.
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Vladislav Olegovich Sarzhevskii, Yu.N. Dubinina & V.Ya. Mel'nichenko. (2017) Diagnostic and Prognostic Value of Biochemical Markers of Infectious Complications of High-Dose Therapy with Autologous Hematopoietic Stem Cell Transplantation in Malignant Lymphoproliferative Diseases. Clinical oncohematology 10:1, pages 113-119.
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Hani Mawardi, Ashley E. Manlove, Linda S. Elting, Francisco M. Marty, Nathaniel S. Treister & Sook-Bin Woo. (2014) Cost analysis of dental services needed before hematopoietic cell transplantation. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117:1, pages 59-66.
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Charulata Ramaprasad & Kenneth J. Pursell. 2014. Infectious Complications in Cancer Patients. Infectious Complications in Cancer Patients 351 370 .
M. Sato, H. Nakasone, H. Wada, R. Yamasaki, Y. Ishihara, K. Sakamoto, K. Kawamura, M. Ashizawa, T. Machishima, K. Terasako, S.-I. Kimura, M. Kikuchi, A. Tanihara, R. Yamazaki, Y. Tanaka, J. Kanda, S. Kako, J. Nishida & Y. Kanda. (2013) Prediction of infectious events by the high-sensitivity C-reactive protein level before autologous hematopoietic cell transplantation for lymphoma and multiple myeloma. Transplant Infectious Disease 15:4, pages E169-E171.
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Eric J. Bow. (2013) Infection in Neutropenic Patients with Cancer. Critical Care Clinics 29:3, pages 411-441.
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A Wolska, T Robak, A Szmigielska-Kaplon, A Pluta, P Kopka & A Wierzbowska. (2012) Ciprofloxacin prophylaxis for patients undergoing high-dose chemotherapy and autologous stem cell transplantation (ASCT) – a single-center experience. Advances in Medical Sciences 57:1, pages 118-123.
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Marilyn J. Hammer & Joachim G. Voss. (2012) Malglycemia and Cancer: Introduction to a Conceptual Model. Oncology Nursing Forum 39:3, pages E275-E287.
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Christian Kjellander, Magnus Björkholm, Honar Cherif, Mats Kalin & Christian G. Giske. (2012) Hematological: Low all‐cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single‐center study. European Journal of Haematology 88:5, pages 422-430.
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Auni Juutilainen, Sari Hämäläinen, Juuso Niemenpää, Taru Kuittinen, Kari Pulkki, Irma Koivula, Leo Niskanen & Esa Jantunen. (2011) Serum cortisol and inflammatory response in neutropenic fever. Annals of Hematology 90:12, pages 1467-1475.
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Shin Ahn, Yoon-Seon Lee, Yun-Hee Chun, In-Ho Kwon, Won Kim, Kyung Soo Lim, Tae Won Kim & Kyoo-Hyung Lee. (2010) Predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia. Supportive Care in Cancer 19:8, pages 1151-1158.
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Panagiotis Samaras, Marcel Blickenstorfer, Raffaele Daniele Siciliano, Sarah R. Haile, Elefteri M. Buset, Ulf Petrausch, Axel Mischo, Hanspeter Honegger, Urs Schanz, Georg Stussi, Rolf A. Stahel, Alexander Knuth, Frank Stenner-Liewen & Christoph Renner. (2010) Pegfilgrastim reduces the length of hospitalization and the time to engraftment in multiple myeloma patients treated with melphalan 200 and auto-SCT compared with filgrastim. Annals of Hematology 90:1, pages 89-94.
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S Mathew, N Adel, R D Rice, K Panageas, E T Duck, R L Comenzo, T Kewalramani & S D Nimer. (2010) Retrospective comparison of the effects of filgrastim and pegfilgrastim on the pace of engraftment in auto-SCT patients. Bone Marrow Transplantation 45:10, pages 1522-1527.
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Irma Matinlauri, Auni Juutilainen, Sari Hämäläinen, Irma Koivula, Taru Kuittinen & Esa Jantunen. (2010) Fibrinogen and antithrombin in hematological patients with neutropenic fever. Open Medicine 5:4, pages 520-526.
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Sari Hämäläinen, Auni Juutilainen, Irma Matinlauri, Taru Kuittinen, Esko Ruokonen, Irma Koivula & Esa Jantunen. (2009) Serum vascular endothelial growth factor in adult haematological patients with neutropenic fever: a comparison with C-reactive protein. European Journal of Haematology 83:3, pages 251-257.
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