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ORIGINAL ARTICLE

Decreased urinary concentration of Tamm–Horsfall protein is associated with development of renal failure and cardiovascular death within 20 years in type 1 but not in type 2 diabetic patients

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Pages 168-174 | Received 02 Feb 2007, Published online: 09 Jul 2009

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Read on this site (3)

Song Mao, Aihua Zhang & Songming Huang. (2014) The signaling pathway of uromodulin and its role in kidney diseases. Journal of Receptors and Signal Transduction 34:6, pages 440-444.
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Chien-Hsing Wu, Chien-Te Lee, Chih-Hsiung Lee, Tien-Tsai Cheng, Hsueh-Wen Chang, Eton Lin, Feng-Rong Chuang, Hui-Ping Yang, Ying-Chou Chen, Chien-Yi Wu & Chung-Jen Chen. (2011) Urinary UMOD Excretion and Chronic Kidney Disease in Gout Patients: Cross-Sectional Case–Control Study. Renal Failure 33:2, pages 164-168.
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Anna Möllsten & Ole Torffvit. (2010) Tamm–Horsfall protein gene is associated with distal tubular dysfunction in patients with type 1 diabetes. Scandinavian Journal of Urology and Nephrology 44:6, pages 438-444.
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Articles from other publishers (31)

Asmaa Ghafer, Abdulameer M. Ghareeb & Abdul Hussain M. Al-Faisal. (2023) Association the allelic variation and SNP rs12917707 genotyping with UMOD serum level among Iraqi patients infected with uropathogenic Escherichia coli. Bionatura 8:CSS 1, pages 1-12.
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Farah Thamer Hasan & Mahmood Al-Mualm. (2021) ASSOCIATION OF GENETIC POLYMORPHISM AND EXPRESSION OF UMOD GENE AND CHRONIC KIDNEY DISEASE. Wiadomości Lekarskie 74:9, pages 2297-2300.
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Natalia Nowak. (2020) Protective factors as biomarkers and targets for prevention and treatment of diabetic nephropathy: From current human evidence to future possibilities. Journal of Diabetes Investigation 11:5, pages 1085-1096.
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Dominik Steubl, Petra Buzkova, Pranav S Garimella, Joachim H Ix, Prasad Devarajan, Michael R Bennett, Paulo H M Chaves, Michael G Shlipak, Nisha Bansal & Mark J Sarnak. (2020) Association of serum uromodulin with mortality and cardiovascular disease in the elderly—the Cardiovascular Health Study. Nephrology Dialysis Transplantation 35:8, pages 1399-1405.
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Nolubabalo Unati Nqebelele, Caroline Dickens, Therese Dix-Peek, Raquel Duarte & Saraladevi Naicker. (2019) Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease . International Journal of Nephrology 2019, pages 1-7.
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Sarah G. Fitzpatrick & Sara C. Gordon. 2018. Apoptosis and Beyond. Apoptosis and Beyond 83 98 .
Olena Maydan, Paul G. McDade, Yan Liu, Xue-Ru Wu, Douglas G. Matsell & Allison A. Eddy. (2018) Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy. Physiological Reports 6:6, pages e13654.
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Andrew Bostom, Dominik Steubl, Pranav S. Garimella, Nora Franceschini, Mary B. Roberts, Andreas Pasch, Joachim H. Ix, Katherine R. Tuttle, Anastasia Ivanova, Theresa Shireman, S. Joseph Kim, Reginald Gohh, Daniel E. Weiner, Andrew S. Levey, Chi-yuan Hsu, John W. Kusek & Charles B. Eaton. (2018) Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure. American Journal of Nephrology 47:4, pages 275-282.
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Andrew G. Bostom, Dominik Steubl & Allon N. Friedman. (2017) Hypothesis: Potential Utility of Serum and Urine Uromodulin Measurement in Kidney Transplant Recipients?. Transplantation Direct 3:11, pages e219.
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Graciela E. Delgado, Marcus E. Kleber, Hubert Scharnagl, Bernhard K. Krämer, Winfried März & Jürgen E. Scherberich. (2017) Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography. Journal of the American Society of Nephrology 28:7, pages 2201-2210.
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Andreas Leiherer, Axel Muendlein, Christoph H. Saely, Janine Ebner, Eva M. Brandtner, Peter Fraunberger & Heinz Drexel. (2017) Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients. International Journal of Cardiology 231, pages 6-12.
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Neng-jun Lou, Yi-hong Ni, Hong-ying Jia, Jing-ti Deng, Lu Jiang, Feng-jie Zheng & Ai-li Sun. (2017) Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease. Journal of Diabetes Research 2017, pages 1-6.
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LIWEN CUI, YALING BAI, JINSHENG XU, JUNXIA ZHANG, HUIRAN ZHANG, SHENGLEI ZHANG & WENBO ZHANG. (2015) Single-nucleotide polymorphism of the UMOD promoter is associated with the outcome of chronic kidney disease patients. Biomedical Reports 3:4, pages 588-592.
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Xue-Ru Wu. (2014) Interstitial calcinosis in renal papillae of genetically engineered mouse models: relation to Randall’s plaques. Urolithiasis 43:S1, pages 65-76.
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Peter Holmquist & Petru Liuba. (2014) Urine π-Glutathion S-transferase but not Tamm-Horsfall protein correlates with Carotid artery intima media thickness in childhood type1 diabetes. BMC Cardiovascular Disorders 14:1.
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Jingjing Zhou, Yuqing Chen, Ying Liu, Sufang Shi, Suxia Wang, Xueying Li, Hong Zhang & Haiyan Wang. (2013) Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy. PLoS ONE 8:8, pages e71023.
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Petra Zürbig, George Jerums, Peter Hovind, Richard J. MacIsaac, Harald MischakStine E. Nielsen, Sianna Panagiotopoulos, Frederik Persson & Peter Rossing. (2012) Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy. Diabetes 61:12, pages 3304-3313.
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Yan Liu, Tarek M. El-Achkar & Xue-Ru Wu. (2012) Tamm-Horsfall Protein Regulates Circulating and Renal Cytokines by Affecting Glomerular Filtration Rate and Acting as a Urinary Cytokine Trap. Journal of Biological Chemistry 287:20, pages 16365-16378.
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Peter Holmquist & Petru Liuba. (2012) Urine α-Glutathione S-Transferase, systemic inflammation and arterial function in juvenile type 1 diabetes. Journal of Diabetes and its Complications 26:3, pages 199-204.
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Yanchun Qu, E Du, Yue Zhang, Shengzhi Li, Ruifa Han & Mengsheng Qiu. (2012) Changes in the Expression of Bone Morphogenetic Protein 7 and Tamm– Horsfall Protein in the Early Stages of Diabetic Nephropathy. Nephro-Urology Monthly 4:2, pages 466-469.
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Tarek M. El-Achkar & Xue-Ru Wu. (2012) Uromodulin in Kidney Injury: An Instigator, Bystander, or Protector?. American Journal of Kidney Diseases 59:3, pages 452-461.
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Michael R. Bennett & Prasad Devarajan. (2010) Proteomic analysis of acute kidney injury: Biomarkers to mechanisms. PROTEOMICS – Clinical Applications 5:1-2, pages 67-77.
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Yasuko Kawakami, Naoki Sakai, Kiyoko Shiba & Kenji Sato. (2011) Urinary protein profiles in patients with ureterolithiasis and nephrolithiasis. Journal of Electrophoresis 55:1, pages 5-12.
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Mayuka Goya, Mie Arai, Kenjiro Yamanaka, Yoshinori Kanai, Kiyoko Shiba & Kenji Sato. (2011) Variations of urinary protein excretion and α1-antitrypsin molecular size by glycemic control in type 2 diabetic patients. Journal of Electrophoresis 55:1, pages 13-22.
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Anna Reznichenko, Marcory C.R.F. van Dijk, Jaap Homan van der Heide, Stephan J.L. Bakker, Marc Seelen & Gerjan Navis. (2011) Uromodulin in Renal Transplant Recipients: Elevated Urinary Levels and Bimodal Association with Graft Failure. American Journal of Nephrology 34:5, pages 445-451.
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David M. Good, Petra Zürbig, Àngel Argilés, Hartwig W. Bauer, Georg Behrens, Joshua J. Coon, Mohammed Dakna, Stéphane Decramer, Christian Delles, Anna F. Dominiczak, Jochen H.H. Ehrich, Frank Eitner, Danilo Fliser, Moritz Frommberger, Arnold Ganser, Mark A. Girolami, Igor Golovko, Wilfried Gwinner, Marion Haubitz, Stefan Herget-Rosenthal, Joachim Jankowski, Holger Jahn, George Jerums, Bruce A. Julian, Markus Kellmann, Volker Kliem, Walter Kolch, Andrzej S. Krolewski, Mario Luppi, Ziad Massy, Michael Melter, Christian Neusüss, Jan Novak, Karlheinz Peter, Kasper Rossing, Harald Rupprecht, Joost P. Schanstra, Eric Schiffer, Jens-Uwe Stolzenburg, Lise Tarnow, Dan Theodorescu, Visith Thongboonkerd, Raymond Vanholder, Eva M. Weissinger, Harald Mischak & Philippe Schmitt-Kopplin. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular & Cellular Proteomics 9:11, pages 2424-2437.
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Yan LiuLan MoDavid S. GoldfarbAndrew P. EvanFengxia Liang, Saeed R. Khan, John C. Lieske & Xue-Ru Wu. (2010) Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein. American Journal of Physiology-Renal Physiology 299:3, pages F469-F478.
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Stine Elkjaer NielsenTakeshi SugayaPeter HovindTsuneharu BabaHans-Henrik ParvingPeter Rossing. (2010) Urinary Liver-Type Fatty Acid-Binding Protein Predicts Progression to Nephropathy in Type 1 Diabetic Patients. Diabetes Care 33:6, pages 1320-1324.
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S. Prajczer, U. Heidenreich, W. Pfaller, P. Kotanko, K. Lhotta & P. Jennings. (2010) Evidence for a role of uromodulin in chronic kidney disease progression. Nephrology Dialysis Transplantation 25:6, pages 1896-1903.
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Jing YangPascale H. LaneJennifer S. PollockPamela K. Carmines. (2010) Protein Kinase C-Dependent NAD(P)H Oxidase Activation Induced by Type 1 Diabetes in Renal Medullary Thick Ascending Limb. Hypertension 55:2, pages 468-473.
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Tara K. Sigdel, Amit Kaushal, Marina Gritsenko, Angela D. Norbeck, Wei‐Jun Qian, Wenzhong Xiao, David G. CampIIII, Richard D. Smith & Minnie M. Sarwal. (2010) Shotgun proteomics identifies proteins specific for acute renal transplant rejection. PROTEOMICS – Clinical Applications 4:1, pages 32-47.
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