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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 2
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Original Articles

5-Ethoxymethylidene-4-thioxo-2-thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3-d][1,3]thiazole Core

Dmytro Atamanyuk Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
,
Borys Zimenkovsky Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
,
Vasyl Atamanyuk Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
&
Roman Lesyk Department of Pharmaceutical, Organic, and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, UkraineCorrespondence[email protected]
Pages 237-244 | Received 10 Apr 2013, Published online: 29 Oct 2013

Citations (26)

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Danylo Kaminskyy, Anna Kryshchyshyn & Roman Lesyk. (2017) Recent developments with rhodanine as a scaffold for drug discovery. Expert Opinion on Drug Discovery 12:12, pages 1233-1252.
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Andrii Lozynskyi, Borys Zimenkovsky, Andrzej K. Gzella & Roman Lesyk. (2015) Arylidene Pyruvic Acids Motif in the Synthesis of New 2H,5H-Chromeno[4′,3′:4,5]thiopyrano[2,3-d]thiazoles via Tandem Hetero-Diels–Alder-Hemiacetal Reaction. Synthetic Communications 45:19, pages 2266-2270.
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Articles from other publishers (24)

Aelvish D. Padariya, Nirbhay K. Savaliya, Milan P. Dhaduk, Ravi A. Dabhi, Bhupesh S. Bhatt, Vaibhav D. Bhatt & Mohan N. Patel. (2024) Synthesis and characterization of quinoxaline-based rhenium(I) organometallic compounds: Biological and computational applications. Journal of Molecular Structure 1302, pages 137477.
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Anna Kryshchyshyn-Dylevych, Danylo Kaminskyy & Roman Lesyk. (2023) In‐vitro antiviral screening of some thiopyranothiazoles. Chemico-Biological Interactions 386, pages 110738.
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Iryna Ivasechko, Andrii Lozynskyi, Julia Senkiv, Piotr Roszczenko, Yuliia Kozak, Nataliya Finiuk, Olga Klyuchivska, Nataliya Kashchak, Nazar Manko, Zvenyslava Maslyak, Danylo Lesyk, Andriy Karkhut, Svyatoslav Polovkovych, Robert Czarnomysy, Olga Szewczyk, Andriy Kozytskiy, Olexandr Karpenko, Dmytro Khyluk, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Petr Dzubak, Sona Gurska, Marian Hajduch, Rostyslav Stoika & Roman Lesyk. (2023) Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). European Journal of Medicinal Chemistry 252, pages 115304.
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Adel Alghamdi, Amr S. Abouzied, Abdulwahab Alamri, Sirajudheen Anwar, Mukhtar Ansari, Ibrahim Khadra, Yasser H. Zaki & Sobhi M. Gomha. (2023) Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors. Current Issues in Molecular Biology 45:2, pages 1422-1442.
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Monika Bar, Bartosz Skóra, Anna Tabęcka-Łonczyńska, Serhii Holota, Dmytro Khyluk, Olexandra Roman, Roman Lesyk & Konrad A. Szychowski. (2022) New 4-thiazolidinone-based molecules Les-2769 and Les-3266 as possible PPARγ modulators. Bioorganic Chemistry 128, pages 106075.
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Ihor Yushyn, Serhii Holota, Oksana Ivantsiv & Roman Lesyk. (2022) rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid. Molbank 2022:3, pages M1410.
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Konrad A. Szychowski, Bartosz Skóra, Anna Kryshchyshyn-Dylevych, Danylo Kaminskyy, Jakub Tobiasz, Roman B. Lesyk & Jan Gmiński. (2021) 4-Thiazolidinone-based derivatives do not affect differentiation of mouse embryo fibroblasts (3T3-L1 cell line) into adipocytes. Chemico-Biological Interactions 345, pages 109538.
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Konrad A. Szychowski, Bartosz Skóra, Anna Kryshchyshyn-Dylevych, Danylo Kaminskyy, Dmytro Khyluk & Roman Lesyk. (2021) 4-thiazolidinone-based derivatives rosiglitazone and pioglitazone affect the expression of antioxidant enzymes in different human cell lines. Biomedicine & Pharmacotherapy 139, pages 111684.
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Anna Kryshchyshyn, Danylo Kaminskyy, Philippe Grellier & Roman Lesyk. 2021. Azoles - Synthesis, Properties, Applications and Perspectives. Azoles - Synthesis, Properties, Applications and Perspectives.
Meenakshi Negi, Pooja A. Chawla, Abdul Faruk & Viney Chawla. (2020) Role of heterocyclic compounds in SARS and SARS CoV-2 pandemic. Bioorganic Chemistry 104, pages 104315.
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Serhii Holota, Anna Kryshchyshyn, Halyna Derkach, Yaroslava Trufin, Inna Demchuk, Andrzej Gzella, Philippe Grellier & Roman Lesyk. (2019) Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity. Bioorganic Chemistry 86, pages 126-136.
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Sonam Nirwan, Varun Chahal & Rita Kakkar. (2019) Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications. Journal of Heterocyclic Chemistry 56:4, pages 1239-1253.
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Paolo Quadrelli & Mattia Moiola. 2019. Modern Applications of Cycloaddition Chemistry. Modern Applications of Cycloaddition Chemistry 1 83 .
Anna Kryshchyshyn, Olexandra Roman, Andrii Lozynskyi & Roman Lesyk. (2018) Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry. Scientia Pharmaceutica 86:2, pages 26.
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Konrad A. Szychowski, Marcin L. Leja, Danylo V. Kaminskyy, Anna P. Kryshchyshyn, Urszula E. Binduga, Oleh R. Pinyazhko, Roman B. Lesyk, Jakub Tobiasz & Jan Gmiński. (2017) Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ). European Journal of Medicinal Chemistry 141, pages 162-168.
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Danylo Kaminskyy, Anna Kryshchyshyn & Roman Lesyk. (2017) 5-Ene-4-thiazolidinones – An efficient tool in medicinal chemistry. European Journal of Medicinal Chemistry 140, pages 542-594.
Crossref
N. I. Zelisko, N. S. Finiuk, V. M. Shvets, Yu. O. Medvid, R. S. Stoika & R. B. Lesyk. (2017) Screening of spiro-substituted thiopyrano[2,3-d]thiazoles for their cytotoxic action on tumor cells. Biopolymers and Cell 33:4, pages 282-290.
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A. P. Kryshchyshyn, D. V. Atamanyuk, D. V. Kaminskyy, Ph. Grellier & R. B. Lesyk. (2017) Investigation of anticancer and anti-parasitic activity of thiopyrano[2,3-d]thiazoles bearing norbornane moiety. Biopolymers and Cell 33:3, pages 183-205.
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Nataliya Zelisko, Olexandr Karpenko, Volodymyr Muzychenko, Andrzej Gzella, Philippe Grellier & Roman Lesyk. (2017) trans -Aconitic acid-based hetero -Diels-Alder reaction in the synthesis of thiopyrano[2,3- d ][1,3]thiazole derivatives. Tetrahedron Letters 58:18, pages 1751-1754.
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Konrad A. Szychowski, Marcin L. Leja, Danylo V. Kaminskyy, Urszula E. Binduga, Oleh R. Pinyazhko, Roman B. Lesyk & Jan Gmiński. (2017) Study of novel anticancer 4-thiazolidinone derivatives. Chemico-Biological Interactions 262, pages 46-56.
Crossref
Andrii Lozynskyi, Borys Zimenkovsky, Andriy Karkhut, Svyatoslav Polovkovych, Andrzej K. Gzella & Roman Lesyk. (2016) Application of the 2(5 H )furanone motif in the synthesis of new thiopyrano[2,3- d ]thiazoles via the hetero-Diels–Alder reaction and related tandem processes. Tetrahedron Letters 57:30, pages 3318-3321.
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Julia Senkiv, Nataliya Finiuk, Danylo Kaminskyy, Dmytro Havrylyuk, Magdalena Wojtyra, Iryna Kril, Andrzej Gzella, Rostyslav Stoika & Roman Lesyk. (2016) 5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells. European Journal of Medicinal Chemistry 117, pages 33-46.
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Nataliya Zelisko, Dmytro Atamanyuk, Yuri Ostapiuk, Andriy Bryhas, Vasyl Matiychuk, Andrzej Gzella & Roman Lesyk. (2015) Synthesis of fused thiopyrano[2,3-d][1,3]thiazoles via hetero-Diels–Alder reaction related tandem and domino processes. Tetrahedron 71:50, pages 9501-9508.
Crossref
Dmytro Atamanyuk, Borys Zimenkovsky, Vasyl Atamanyuk & Roman Lesyk. (2014) ChemInform Abstract: 5‐Ethoxymethylidene‐4‐thioxo‐2‐thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3‐d][1,3]thiazole Core.. ChemInform 45:22.
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