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Jimmy Flarakos, Yancy Du, Helen Gu, Lai Wang, Heidi J. Einolf, Dung Y. Chun, Bing Zhu, Natalia Alexander, Adrienne Natrillo, Imad Hanna, Lillian Ting, Wei Zhou, Kiran Dole, Haiying Sun, Steven J. Kovacs, Daniel S. Stein, S. Ken Tanaka, Stephen Villano & James B. Mangold. (2017) Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline. Xenobiotica 47:8, pages 682-696.
Read now
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Marwa E. Elsherbiny & Dion R. Brocks. (2011) The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition. Drug Metabolism Reviews 43:4, pages 457-475.
Read now
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Juhyun Kim, Concepcion Peraire, Josep Solà, Karla M. Johanning, James T. Dalton & Karen A. Veverka. (2011) Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms. Xenobiotica 41:10, pages 851-862.
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Shu-Feng Zhou, Bo Wang, Li-Ping Yang & Jun-Ping Liu. (2010) Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metabolism Reviews 42:2, pages 268-354.
Read now
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J. R. Kenny, L. Chen, D. F. McGinnity, K. Grime, K. M. Shakesheff, B. Thomson & R. Riley. (2008) Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. Xenobiotica 38:12, pages 1500-1517.
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N. J. Hewitt, E. L. Lecluyse & S. S. Ferguson. (2007) Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and correlations. Xenobiotica 37:10-11, pages 1196-1224.
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Read now
Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler. (2007) Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies. Drug Metabolism Reviews 39:1, pages 159-234.
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Read now
P. D. Worboys & D. J. Carlile. (2001) Implications and consequences of enzyme induction on preclinical and clinical drug development. Xenobiotica 31:8-9, pages 539-556.
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Articles from other publishers (51)
Susan Omar Rasool, Ata Mirzaei Nahr, Sania Eskandari, Milad Hosseinzadeh, Soheila Asoudeh Moghanloo & Farnoosh Ebrahimzadeh. (2021) Drug-disease interactions of differentially expressed genes in COVID-19 liver samples: an in-silico analysis. Investigación Clínica 62:4, pages 316-324.
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Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones & Phillip D. Yates. (2021) Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment. Drug Metabolism and Disposition 49:1, pages 94-110.
Crossref
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Shuo Yang, Matthias Diem, Jakob D. H. Liu, Sebastiaan Wesseling, Jacques Vervoort, Chris Oostenbrink & Ivonne M. C. M. Rietjens. (2020) Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix. Archives of Toxicology 94:4, pages 1349-1365.
Crossref
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Viktoriia Burkina, Martin Krøyer Rasmussen, Yelyzaveta Oliinychenko & Galia Zamaratskaia. (2019) Porcine cytochrome 2A19 and 2E1. Basic & Clinical Pharmacology & Toxicology 124:1, pages 32-39.
Crossref
Crossref
Kim Vanstraelen, Juergen Prattes, Johan Maertens, Katrien Lagrou, Hélène Schoemans, Nele Peersman, Pieter Vermeersch, Koen Theunissen, Raf Mols, Patrick Augustijns, Pieter Annaert, Martin Hoenigl & Isabel Spriet. (2016) Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients. European Journal of Clinical Pharmacology 72:8, pages 953-963.
Crossref
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M. Farooq, E. J. Kelly & J. D. Unadkat. (2016) CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug Metabolism and Disposition 44:5, pages 750-757.
Crossref
Crossref
Ellen M. McDonagh, Catherine Wassenaar, Sean P. David, Rachel F. Tyndale, Russ B. Altman, Michelle Whirl-Carrillo & Teri E. Klein. (2012) PharmGKB summary. Pharmacogenetics and Genomics 22:9, pages 695-708.
Crossref
Crossref
Michael B. Black, Robert A. Budinsky, Alan Dombkowski, Daniela Cukovic, Edward L. LeCluyse, Stephen S. Ferguson, Russell S. Thomas & J. Craig Rowlands. (2012) Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicological Sciences 127:1, pages 199-215.
Crossref
Crossref
Zdenek Dvorak. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics
223
258
.
Andy Z. X. Zhu & Rachel F. Tyndale. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics
465
492
.
R. Thier, B. Pesch, G. Krause & T. Schulz. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety
240
283
.
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety
5
34
.
Tamihide Matsunaga, Masataka Maruyama, Tsutomu Matsubara, Kiyoshi Nagata, Yasushi Yamazoe & Shigeru Ohmori. (2012) Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells. Drug Metabolism and Pharmacokinetics 27:6, pages 653-657.
Crossref
Crossref
Robert A. Budinsky, Edward L. LeCluyse, Stephen S. Ferguson, J. Craig Rowlands & Ted Simon. (2010) Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran. Toxicological Sciences 118:1, pages 224-235.
Crossref
Crossref
Kayoko Maezawa, Tamihide Matsunaga, Takashi Takezawa, Makoto Kanai, Satoshi Ohira & Shigeru Ohmori. (2010) Cytochrome P450 3As Gene Expression and Testosterone 6.BETA.-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term. Biological and Pharmaceutical Bulletin 33:2, pages 249-254.
Crossref
Crossref
J. Brian Houston & Aleksandra Galetin. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions
169
215
.
Masuhiro NISHIMURA. (2009) Evaluation of Induction of Drug-metabolizing Enzyme mRNAs in Primary Cultures of Cryopreserved Human and Cynomolgus Monkey Hepatocytes凍結ヒト及びカニクイザル肝細胞の初代培養系を用いた薬物曝露による薬物代謝酵素mRNA発現変動の評価. YAKUGAKU ZASSHI 129:7, pages 815-820.
Crossref
Crossref
Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser & Robert J. Riley. (2009) Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells. Drug Metabolism and Disposition 37:6, pages 1259-1268.
Crossref
Crossref
Jill C. Mwenifumbo & Rachel F. Tyndale. 2009. Nicotine Psychopharmacology. Nicotine Psychopharmacology
235
259
.
Neal L. Benowitz, Janne Hukkanen & Peyton JacobIIIIII. 2009. Nicotine Psychopharmacology. Nicotine Psychopharmacology
29
60
.
P. Olinga, M.G.L. Elferink, A.L. Draaisma, M.T. Merema, J.V. Castell, G. Pérez & G.M.M. Groothuis. (2008) Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. European Journal of Pharmaceutical Sciences 33:4-5, pages 380-389.
Crossref
Crossref
Luba Vasiluk, Linda J. Pinto, Wing Shan Tsang, Frank A.P.C. Gobas, Curtis Eickhoff & Margo M. Moore. (2008) The uptake and metabolism of benzo[a]pyrene from a sample food substrate in an in vitro model of digestion. Food and Chemical Toxicology 46:2, pages 610-618.
Crossref
Crossref
Mark W. KieranRoger J. PackerArzu OnarSusan M. BlaneyPeter PhillipsIan F. PollackJ. Russell GeyerSri GururanganAnu BanerjeeStewart GoldmanChristopher D. TurnerJean B. BelascoAlberto BroniscerYali ZhuEmily FrankPaul KirschmeierPaul StatkevichAntoine YverJames M. BoyettLarry E. Kun. (2007) Phase I and Pharmacokinetic Study of the Oral Farnesyltransferase Inhibitor Lonafarnib Administered Twice Daily to Pediatric Patients With Advanced Central Nervous System Tumors Using a Modified Continuous Reassessment Method: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology 25:21, pages 3137-3143.
Crossref
Crossref
Paul P.C. PoyckRuurdtje HoekstraAniska ChhattaLysbeth Ten BloemendaalAlbert C.W.A. van WijkDaniele GalavottiThomas M. van GulikRobert A.F.M. Chamuleau. (2007) Time-Related Analysis of Metabolic Liver Functions, Cellular Morphology, and Gene Expression of Hepatocytes Cultured in the Bioartificial Liver of the Academic Medical Center in Amsterdam (AMC-BAL). Tissue Engineering 13:6, pages 1235-1246.
Crossref
Crossref
Martin Svoboda, Theresia Thalhammer, Sylvia Aust, Ferdi Arrich, Ojan Assadian & Cyril D. Toma. (2007) Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors. Journal of Surgical Oncology 95:7, pages 572-581.
Crossref
Crossref
Nicola J. Hewitt, Ruben de Kanter & Edward LeCluyse. (2007) Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry—Do they comply with FDA recommendations?. Chemico-Biological Interactions 168:1, pages 51-65.
Crossref
Crossref
Masataka Maruyama, Tamihide Matsunaga, Eri Harada & Shigeru Ohmori. (2007) Comparison of Basal Gene Expression and Induction of CYP3As in HepG2 and Human Fetal Liver Cells. Biological and Pharmaceutical Bulletin 30:11, pages 2091-2097.
Crossref
Crossref
Y. Parmentier, M.-J. Bossant, M. Bertrand & B. Walther. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
231
257
.
Dermot F. McGinnity, Amanda J. Berry, Jane R. Kenny, Ken Grime & Robert J. Riley. (2006) EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES. Drug Metabolism and Disposition 34:8, pages 1291-1300.
Crossref
Crossref
Mette Gillberg, Mette T. Skaanild & Christian Friis. (2006) Regulation of Gender-Dependent CYP2A Expression in Pigs: Involvement of Androgens and CAR. Basic & Clinical Pharmacology & Toxicology 98:5, pages 480-487.
Crossref
Crossref
Masuhiro Nishimura, Akiko Koeda, Emako Suzuki, Yuichi Kawano, Mitsuo Nakayama, Tetsuo Satoh, Shizuo Narimatsu & Shinsaku Naito. (2006) Regulation of mRNA Expression of MDR1, MRP1, MRP2 and MRP3 by Prototypical Microsomal Enzyme Inducers in Primary Cultures of Human and Rat Hepatocytes. Drug Metabolism and Pharmacokinetics 21:4, pages 297-307.
Crossref
Crossref
Kajsa P. Persson, Susanne Ekehed, Charlotta Otter, E. S. Mareike Lutz, Jane McPheat, Collen M. Masimirembwa & Tommy B. Andersson. (2006) Evaluation of Human Liver Slices and Reporter Gene Assays as Systems for Predicting the Cytochrome P450 Induction Potential of Drugs in Vivo in Humans. Pharmaceutical Research 23:1, pages 56-69.
Crossref
Crossref
Michael Haberl, Birgit Anwald, Kathrin Klein, Regina Weil, Christine Fu, Akçahan Gepdiremen, Ulrich M. Zanger, Urs A. Meyer & Leszek Wojnowski. (2005) Three haplotypes associated with CYP2A6 phenotypes in Caucasians. Pharmacogenetics and Genomics 15:9, pages 609-624.
Crossref
Crossref
Dirk Roymans, Pieter Annaert, Jos Van Houdt, Adri Weygers, Jan Noukens, Carlo Sensenhauser, José Silva, Cis Van Looveren, Jan Hendrickx, Geert Mannens & Willem Meuldermans. (2005) EXPRESSION AND INDUCTION POTENTIAL OF CYTOCHROMES P450 IN HUMAN CRYOPRESERVED HEPATOCYTES. Drug Metabolism and Disposition 33:7, pages 1004-1016.
Crossref
Crossref
Janne Hukkanen, Pleyton JacobIIIIII & Neal L. Benowitz. (2005) Metabolism and Disposition Kinetics of Nicotine. Pharmacological Reviews 57:1, pages 79-115.
Crossref
Crossref
Masuhiro Nishimura, Tsuyoshi Yokoi, Chise Tateno, Miho Kataoka, Eiji Takahashi, Toru Horie, Katsutoshi Yoshizato & Shinsaku Naito. (2005) Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver. Drug Metabolism and Pharmacokinetics 20:2, pages 121-126.
Crossref
Crossref
M. Teresa Donato, Alfonso Serralta, Nuria Jiménez, Gabriela Pérez, José V. Castell, José Mir & M. José Gómez-Lechón. (2005) LIVER GRAFTS PRESERVED IN CELSIOR SOLUTION AS SOURCE OF HEPATOCYTES FOR DRUG METABOLISM STUDIES: COMPARISON WITH SURGICAL LIVER BIOPSIES. Drug Metabolism and Disposition 33:1, pages 108-114.
Crossref
Crossref
Thomayant Prueksaritanont, Karen M. Richards, Yue Qiu, Kristine Strong-Basalyga, Alisha Miller, Chunze Li, Roy Eisenhandler & Edward J. Carlini. (2005) Comparative Effects of Fibrates on Drug Metabolizing Enzymes in Human Hepatocytes. Pharmaceutical Research 22:1, pages 71-78.
Crossref
Crossref
Zuzana Drobná, Stephen B. Waters, Felecia S. Walton, Edward L. LeCluyse, David J. Thomas & Miroslav Stýblo. (2004) Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicology and Applied Pharmacology 201:2, pages 166-177.
Crossref
Crossref
Kyle Christian, Matti Lang, Patrick Maurel & Françoise Raffalli-Mathieu. (2004)
Interaction of Heterogeneous Nuclear Ribonucleoprotein A1 with Cytochrome P450 2A6 mRNA: Implications for Post-Transcriptional Regulation of the
CYP2A6
Gene
. Molecular Pharmacology 65:6, pages 1405-1414.
Crossref
Crossref
Jessica B. Mills, Kelly A. Rose, Nalini Sadagopan, Jasminder Sahi & Sonia M. F. de Morais. (2004) Induction of Drug Metabolism Enzymes and MDR1 Using a Novel Human Hepatocyte Cell Line. Journal of Pharmacology and Experimental Therapeutics 309:1, pages 303-309.
Crossref
Crossref
Martine Daujat, Gérard Fabre, Marie-José Vilarem, Lydiane Pichard-Garcia, Lionel Drocourt, Jean-Marc Pascussi, Patrick Maurel, Sylvie Klieber, Martine Bourrié, Sabine Gerbal-Chaloin, François Guillou & François Torreilles. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes
337
374
.
Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, R. Scott Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh & Steven A. Wrighton. (2003) THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE. Drug Metabolism and Disposition 31:7, pages 815-832.
Crossref
Crossref
Craig D. Albright, Rudolf I. Salganik, Corneliu N. Craciunescu, Mei‐Heng Mar & Steven H. Zeisel. (2003) Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor‐β1 in immortalized rat hepatocytes. Journal of Cellular Biochemistry 89:2, pages 254-261.
Crossref
Crossref
Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, Scott R. Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh & Steven A. Wrighton. (2003) The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective. The Journal of Clinical Pharmacology 43:5, pages 443-469.
Crossref
Crossref
Ajay Madan, Richard A. Graham, Kathleen M. Carroll, Daniel R. Mudra, L. Alayne Burton, Linda A. Krueger, April D. Downey, Maciej Czerwinski, Jameson Forster, Maria D. Ribadeneira, Liang-Shang Gan, Edward L. LeCluyse, Karl Zech, Philmore RobertsonJr.Jr., Patrick Koch, Lida Antonian, Greg Wagner, Li Yu & Andrew Parkinson. (2003) Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes. Drug Metabolism and Disposition 31:4, pages 421-431.
Crossref
Crossref
Robert J. Edwards, Roger J. Price, Patricia S. Watts, Anthony B. Renwick, J. Michael Tredger, Alan R. Boobis & Brian G. Lake. (2003) Induction of Cytochrome P450 Enzymes in Cultured Precision-Cut Human Liver Slices. Drug Metabolism and Disposition 31:3, pages 282-288.
Crossref
Crossref
Masuhiro NishimuraNobuhiko UedaShinsaku Naito. (2003) Effects of Dimethyl Sulfoxide on the Gene Induction of Cytochrome P450 Isoforms, UGT-Dependent Glucuronosyl Transferase Isoforms, and ABCB1 in Primary Culture of Human Hepatocytes. Biological and Pharmaceutical Bulletin 26:7, pages 1052-1056.
Crossref
Crossref
Seiichi Ishida, Hideto Jinno, Toshiko Tanaka-Kagawa, Masanori Ando, Yasuo Ohno, Shogo Ozawa & Jun-ichi Sawada. (2002) Characterization of human CYP1A1/1A2 induction by DNA microarray and α-naphthoflavone. Biochemical and Biophysical Research Communications 296:1, pages 172-177.
Crossref
Crossref
Zhi-Yi Zhang, Belinda M. King & Y.Nancy Wong. (2001) Quantitative Liquid Chromatography/Mass Spectrometry/Mass Spectrometry Warfarin Assay for in Vitro Cytochrome P450 Studies. Analytical Biochemistry 298:1, pages 40-49.
Crossref
Crossref
Chuang Lu & Albert P. Li. (2001) Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat, minipig, and beagle dog. Chemico-Biological Interactions 134:3, pages 271-281.
Crossref
Crossref