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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 4
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Research Article

Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4

A. B. Renwick TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
D. F. V. Lewis TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
S. Fulford TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
D. Surry TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
B. Williams TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
P. D. Worboys TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
X. Cai TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
R. W. Wang TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
R. J. Price TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
,
B. G. Lake TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
&
D. C. Evans TNO BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
 show all
Pages 187-204 | Published online: 22 Sep 2008

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Carli Weyers, Laura M. K. Dingle, Brendan S. Wilhelmi, Adrienne L. Edkins & Clinton G. L. Veale. (2020) Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity. Drug and Chemical Toxicology 43:6, pages 656-662.
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Yi-Tong Liu, Hai-Ping Hao, Chang-Xiao Liu, Guang-Ji Wang & Hong-Guang Xie. (2007) Drugs as CYP3A Probes, Inducers, and Inhibitors. Drug Metabolism Reviews 39:4, pages 699-721.
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Articles from other publishers (24)

Kenjiro Hanaoka, Takayuki Ikeno, Shimpei IwakiSayaka DeguchiKazuo Takayama, Hiroyuki MizuguchiFumiya Tao, Nobuhiko Kojima, Hisashi OhnoEita Sasaki, Toru Komatsu, Tasuku Ueno, Kazuya Maeda, Hiroyuki KusuharaYasuteru Urano. (2024) A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT). Science Advances 10:7.
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Rongjing He, Ziru Dai, Moshe Finel, Feng Zhang, Dongzhu Tu, Ling Yang & Guangbo Ge. (2023) Fluorescence-Based High-Throughput Assays for Investigating Cytochrome P450 Enzyme-Mediated Drug–Drug Interactions. Drug Metabolism and Disposition 51:10, pages 1254-1272.
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Wen-Qi Meng, Adam C. Sedgwick, Nahyun Kwon, Mingxue Sun, Kai Xiao, Xiao-Peng He, Eric V. Anslyn, Tony D. James & Juyoung Yoon. (2023) Fluorescent probes for the detection of chemical warfare agents. Chemical Society Reviews 52:2, pages 601-662.
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Qiang Jin, JingJing Wu, Yue Wu, Hongxin Li, Moshe Finel, Dandan Wang & Guangbo Ge. (2022) Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives. Acta Pharmaceutica Sinica B 12:3, pages 1068-1099.
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Jing Ning, Zhenhao Tian, Jiayue Wang, Bo Wang, Xiangge Tian, Zhenlong Yu, Xiaokui Huo, Lei Feng, Jingnan Cui, Tony D. James & Xiaochi Ma. (2021) Rational Design of a Two‐Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism‐Based Inactivation. Angewandte Chemie International Edition 61:5.
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Jing Ning, Zhenhao Tian, Jiayue Wang, Bo Wang, Xiangge Tian, Zhenlong Yu, Xiaokui Huo, Lei Feng, Jingnan Cui, Tony D. James & Xiaochi Ma. (2021) Rational Design of a Two‐Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism‐Based Inactivation. Angewandte Chemie 134:5.
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Lei Feng, Jing Ning, Xiangge Tian, Chao Wang, Zhenlong Yu, Xiaokui Huo, Tian Xie, Baojing Zhang, Tony D. James & Xiaochi Ma. (2021) Fluorescent probes for the detection and imaging of Cytochrome P450. Coordination Chemistry Reviews 437, pages 213740.
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Yuanqiang Sun, Pengjuan Sun & Wei Guo. (2021) Fluorescent probes for iron, heme, and related enzymes. Coordination Chemistry Reviews 429, pages 213645.
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Jingjing Wu, Xiaoqing Guan, Ziru Dai, Rongjing He, Xinxin Ding, Ling Yang & Guangbo Ge. (2021) Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives. Coordination Chemistry Reviews 427, pages 213600.
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Jing Ning, Wei Wang, Guangbo Ge, Peng Chu, Feida Long, Yongliang Yang, Yulin Peng, Lei Feng, Xiaochi Ma & Tony D. James. (2019) Target Enzyme‐Activated Two‐Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two‐Dimensional Design Strategy. Angewandte Chemie International Edition 58:29, pages 9959-9963.
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Jing Ning, Wei Wang, Guangbo Ge, Peng Chu, Feida Long, Yongliang Yang, Yulin Peng, Lei Feng, Xiaochi Ma & Tony D. James. (2019) Target Enzyme‐Activated Two‐Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two‐Dimensional Design Strategy. Angewandte Chemie 131:29, pages 10064-10068.
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Yasushi Yamazoe, Takahiro Goto & Masahiro Tohkin. (2019) Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition. Drug Metabolism and Pharmacokinetics 34:2, pages 113-125.
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Pham Thai Giang, Sidika Sakalli, Ganna Fedorova, Sarvenaz Khalili Tilami, Tomas Bakal, Lucie Najmanova, Katerina Grabicova, Jitka Kolarova, Sabine Sampels, Galia Zamaratskaia, Roman Grabic, Tomas Randak, Vladimir Zlabek & Viktoriia Burkina. (2018) Biomarker response, health indicators, and intestinal microbiome composition in wild brown trout (Salmo trutta m. fario L.) exposed to a sewage treatment plant effluent-dominated stream. Science of The Total Environment 625, pages 1494-1509.
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Elias M. Oziolor, Alexis N. Carey & Cole W. Matson. (2017) A non-destructive BFCOD assay for in vivo measurement of cytochrome P450 3A (CYP3A) enzyme activity in fish embryos and larvae. Ecotoxicology 26:6, pages 809-819.
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Johanna Östlund, Vladimir Zlabek & Galia Zamaratskaia. (2017) In vitro inhibition of human CYP2E1 and CYP3A by quercetin and myricetin in hepatic microsomes is not gender dependent. Toxicology 381, pages 10-18.
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Viktoriia Burkina, Galia Zamaratskaia, Rhaul Oliveira, Ganna Fedorova, Katerina Grabicova, Heike Schmidt-Posthaus, Christoph Steinbach, Inês Domingues, Oksana Golovko, Sidika Sakalli, Roman Grabic, Tomas Randak & Vladimir Zlabek. (2016) Sub-lethal effects and bioconcentration of the human pharmaceutical clotrimazole in rainbow trout (Oncorhynchus mykiss). Chemosphere 159, pages 10-22.
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Emily M. Smith & Joanna Y. Wilson. (2010) Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16α-carbonitrile, rifampicin, and β-naphthoflavone. Aquatic Toxicology 97:4, pages 324-333.
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Sepuri Asha & Maravajhala Vidyavathi. (2009) Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review. Applied Biochemistry and Biotechnology 160:6, pages 1699-1722.
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S Teng & M Piquette‐Miller. (2009) Hepatoprotective role of PXR activation and MRP3 in cholic acid‐induced cholestasis. British Journal of Pharmacology 151:3, pages 367-376.
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Larry J. Jolivette & Sean Ekins. 2007. 131 176 .
Michael Murray. 2005. Modern Biopharmaceuticals. Modern Biopharmaceuticals 1603 1636 .
Deborah A. Nicoll-Griffith, Nathalie Chauret, Robert Houle, Stephen H. Day, Michelle D'Antoni & José M. Silva. (2004) USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES. Drug Metabolism and Disposition 32:12, pages 1509-1515.
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David M. Stresser, Stephanie D. Turner, Andrew P. Blanchard, Vaughn P. Miller & Charles L. Crespi. (2002) Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4.. Drug Metabolism and Disposition 30:7, pages 845-852.
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Charles L. Crespi, Vaughn P. Miller & David M. Stresser. 2002. Cytochrome P450 Part C. Cytochrome P450 Part C 276 284 .

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